Hit expansion around chloroxine. by Sam Barker (4832121)

“…This modification causes a significant decrease in this compound’s activity as a co-treatment with ceftazidime, with a <i>p</i>IC50 ≈ 3.4. 5,7-dichloro-2-methyl-8-quinolinol differs from chloroxine by addition of a methyl group in the 2-position (B). …”

Effect of BC-819 on cell growth in different lung cancer cell lines. by Günther Hasenpusch (350166)

“…The influence of BC-819 on bioluminescent A549-C8-luc was examined as well and revealed decreased luciferase and therefore reduced cell growth (more than 50%) as early as after 24 hours (C). …”

Dissociation, and not specific actions of Trypsin-EDTA, acts to suppress neurectoderm formation. by James N. Hughes (319868)

“…Error bars represent sem. (a) denotes a decrease compared to MEDII⁻/Dissociation⁻ where p<0.01. …”

Long-term growth curves of nucleus pulposus chondrocytes (NPCs) obtained from donors of various ages. by Jun-Seok Lee (181420)

“…<p>Plots of cumulative population doubling levels (PDLs) against time in culture (A) and passage number (B). The cumulative PDLs of NPCs from the young group (patients in their 30s, 40s, and 50s) were relatively higher than those from the old group (patients in their 60s and 70s). …”

The reduced expression of ZBRK1 is inversely correlated with the increased expression of KAP1 in cervical cancer specimens. by Li-Fang Lin (449199)

“…<p><b>A</b>, All tumor specimens from 50 patients with different stages of cervical cancer were obtained from surgically resected tissues. …”

<i>C. elegans</i> adapts its roaming behavior to food concentration, both by changing the dwelling/roaming percentage and the speed during the roaming phase. by Juliette Ben Arous (369742)

“…<p>(A–D) Speed histograms of WT <i>C. elegans</i> on different concentration of bacteria (A: 5 10⁴ B: 1.5 10⁵ C: 3 10⁵ D: 5 10⁵ bacteria per cm², at least 15 worms have been recorded per condition, results are presented as mean ± s.e.m.) …”

Data Sheet 1_Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.docx by Hyun-ju Lee (7550741)

“…</p>Methods<p>To determine whether overexpressing or knocking down DYRK1A expression directly in the brain affects cognitive function, neuroinflammation and AD pathology, adeno-associated viruses (AAVs) were injected into the hippocampus of wild-type (WT), 5xFAD, and PS19 mice. Then, cognitive function was assessed via Y-maze and novel object recognition (NOR) tests, and neuroinflammatory responses and AD pathologies were analyzed by real-time PCR, Western blotting, immunofluorescence staining, AD-associated protein activity assays and ELISA.…”

Training at maximal power in resisted sprinting: Optimal load determination methodology and pilot results in team sport athletes by Matt R. Cross (5089268)

“…<div><p>Aims</p><p>In the current study we investigated the effects of resisted sprint training on sprinting performance and underlying mechanical parameters (force-velocity-power profile) based on two different training protocols: (i) loads that represented maximum power output (<i>L</i>_opt) and a 50% decrease in maximum unresisted sprinting velocity and (ii) lighter loads that represented a 10% decrease in maximum unresisted sprinting velocity, as drawn from previous research (<i>L</i>₁₀).…”

DataSheet1_Interaction of Serum Alkaline Phosphatase and Folic Acid Treatment on Chronic Kidney Disease Progression in Treated Hypertensive Adults.docx by Yuanyuan Zhang (101797)

“…The primary outcome was CKD progression, defined as a decrease in estimated glomerular filtration rate (eGFR) of ≥30% and to a level of <60 ml/min/1.73 m² if baseline eGFR was ≥60 ml/min/1.73 m²; or a decrease in eGFR of ≥50% if baseline eGFR was <60 ml/min/1.73 m²; or end-stage renal disease. …”

Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments by Céline Portal (3876436)

“…Ten days of BAK in one eye followed by 4 days without any treatment induced a −18.3% decrease in conjunctival goblet cell density. …”

Difference in GHG emissions (<em>x</em>-axis) and food availability (<em>y</em>-axis) in 2050 for the different scenarios with respect to 'TREND' by H Valin (557174)

“…</strong> Difference in GHG emissions (<em>x</em>-axis) and food availability (<em>y</em>-axis) in 2050 for the different scenarios with respect to 'TREND'. Panels (A)–(C) and (D) delineate domains where food provision increases ((A), (B)) or decreases ((C), (D)) and GHG emission savings increase ((B), (D)) or decrease ((A), (C)). …”

Data_Sheet_1_Effect of Lockdown Amid COVID-19 on Ambient Air Quality in 16 Indian Cities.docx by Amit Kumar Mishra (5644676)

“…SO₂ and O₃ showed an increase over a few cities as well as a decrease over the other cities. …”

Cardiac chambers undergo regionalised reduction in cell size. by Juliana Sánchez-Posada (20636677)

“…<p>(A–D) Quantification of internuclear cardiomyocyte distance as a proxy for cell size reveals an early increase in atrial cardiomyocyte size and a later reduction in ventricular cardiomyocyte size. …”

Renal phenotype of male Akita mice by genetic background. by Jae-Hyung Chang (327325)

“…<p>NR: not reported, ND: Not detected,</p>*<p>Compared to strain matched non-diabetic controls,</p>†<p>Animal models of diabetic complications consortium (ADMCC) criteria: >10-fold increase in albuminuria, >50% decrease in GFR over the lifetime of the animal, Advanced mesangial expansion, Arteriolar hylanosis, >50% increase in GBM thickness, Tubulointerstitial fibrosis,</p>**<p>variable (see text for discussion),</p>‡<p>Increased BUN at 30–40 weeks of age, References: <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Breyer1" target="_blank">[3]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Gurley1" target="_blank">[4]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Gurley2" target="_blank">[5]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Susztak1" target="_blank">[13]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Brosius1" target="_blank">[30]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Hong1" target="_blank">[35]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Haseyama1" target="_blank">[48]</a>.…”

Lifespan measurements of long-lived mitochondrial mutants subjected to RNAi of individual retrograde-response genes. by David Cristina (265223)

“…Right Panel - WT subjected to control (vector-only) RNAi: N = 77, m = 15.1 days; <i>clk-1(−)</i> mutants subjected to control RNAi: N = 137, m = 17.3 days; <i>clk-1(−)</i> mutants subjected to <i>fstr-1/2</i> RNAi: N = 63, m = 14.5 days. …”

MicroRNA expression analyses in Nr2f1^–/– tissues. by David Y. Chiang (389033)

“…<p>(A) The expression of select miRNAs in the Nr2f1^–/– inner ear showing miR-140 and miR-181a were significantly down-regulated by 4.5-fold (P=0.004) and 1.7-fold (P=0.046), respectively, compared to the WT. …”

Supplementary Material for: The effect of high salt diet on oxidative stress by Kozina N. (18775084)

Ex vivo fitness, CTL escape phenotype and sequence evolution of <i>gag</i> p24 CTL escape mutants. by Ryan M. Troyer (265934)

“…The fold escape conferred by each mutation is displayed here as the ratio of effective peptide concentration (EC₅₀) required to elicit 50% of maximal ELISpot signal relative to the pre-escape peptide <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000365#ppat.1000365-Cao2" target="_blank">[54]</a>. …”

FGF19-mediated regulation of liver protein expression resolved by quantitative proteomics. by Vittoria Massafra (613864)

“…Number of proteins, of which expression was decreased (≤ -1.5 fold), unchanged or increased (≥1.5 fold) are indicated. …”

Methodology. by Scott John (228011)

“…Upon binding of lactate YFP and CFP move farther apart, YFP intensity decreases while CFP intensity increases. This leads to a decrease in the FRET ratio YFP/CFP. …”