Toward Measuring <i>Schistosoma</i> Response to Praziquantel Treatment with Appropriate Descriptors of Egg Excretion by Piero L. Olliaro (217564)

“…<div><p>Background</p><p>The control of schistosomiasis emphasizes preventive chemotherapy with praziquantel, which aims at decreasing infection intensity and thus morbidity in individuals, as well as transmission in communities. …”

Image7_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Image3_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta_25–35 via the Autophagy Pathway by Pengjuan Xu (314036)

“…In our study investigating the effect and potential mechanism of triptolide on cytotoxicity of differentiated rat pheochromocytoma cell line (the PC12 cell line is often used as a neuronal developmental model) induced by Amyloid-Beta_25–35 (Aβ_25–35), we used 3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide (MTT) assay, flow cytometry, Western blot, and acridine orange staining to detect whether triptolide could inhibit Aβ_25–35–induced cell apoptosis. …”

Image12_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.JPEG by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Table1_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.XLSX by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

RNA-Seq Transcriptomic Responses of Full-Thickness Dermal Excision Wounds to <i>Pseudomonas aeruginosa</i> Acute and Biofilm Infection by S. L. Rajasekhar Karna (320813)

“…We studied the wound response: towards acute infection at 2, 6, and 24 hrs after inoculating 10⁶ bacteria into day-3 wounds; and, towards more chronic biofilm infection of wounds similarly infected for 24 hrs but then treated with topical antibiotic to coerce biofilm growth and evaluated at day 5 and 9 post-infection. …”

Table2_Efficacy and Safety of Non-Steroidal Mineralocorticoid Receptor Antagonists in Patients With Chronic Kidney Disease and Type 2 Diabetes: A Systematic Review Incorporating an... by Xinrui Jiang (6076712)

“…Compared with finerenone, esaxerenone showed no significant difference in UACR reduction (WMD 0.24, 95% CI −0.016 to 0.496, p = 0.869); apararenone and esaxerenone showed greater decreases in SBP (WMD 1.37, 95% CI 0.456 to 2.284, p = 0.010; WMD 3.11, 95% CI 0.544 to 5,676, p = 0.021).…”

Supplementary Material for: Duration of Serum Phosphorus Control Associated with Overall Mortality in Patients Undergoing Peritoneal Dialysis by Gong N. (9348857)

“…<b><i>Conclusions:</i></b> In summary, both degree and duration of SP control were tightly associated with overall mortality. We should control SP levels as early, as possible, and as long as we could.…”

The negative effect of lipid challenge on autophagy inhibits T cell responses by Ignacio Guerrero-Ros (6587345)

“…Furthermore, analysis of T cells from diet-induced obese mice confirms that high lipid load inhibits activation-induced responses in T cells. We have found that autophagy is inhibited in CD4⁺ T cells exposed <i>in vitro</i> or <i>in vivo</i> to lipid stress, which causes decreased autophagosome formation and degradation. …”

Image1_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Image8_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

DataSheet_1_Distinct effects of rosuvastatin and rosuvastatin/ezetimibe on senescence markers of CD8+ T cells in patients with type 2 diabetes mellitus: a randomized controlled tri... by Sang-Hyeon Ju (15373114)

“…</p>Results<p>The fractions of CD8+CD57+ (senescent CD8+ T cells) and CD4+FoxP3+ (T_reg) significantly decreased after intervention in the rosuvastatin/ezetimibe group (−4.5 ± 14.1% and −1.2 ± 2.3%, respectively), while these fractions showed minimal change in the rosuvastatin group (2.8 ± 9.4% and 1.4 ± 1.5%, respectively). …”

Image13_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.JPEG by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Functional <i>IL6R</i> 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases by Ricardo C. Ferreira (174523)

“…Importantly, reduced expression of membrane-bound IL-6R resulted in impaired IL-6 responsiveness, as measured by decreased phosphorylation of the transcription factors STAT3 and STAT1 following stimulation with IL-6 (<i>P</i>≤5.2×10⁻⁷). …”

Table 1_Exploring the impact of acute solvent exposure on larval zebrafish behaviour.xlsx by Ethan V. Hagen (22702439)

“…Often solvents are used as a vehicle for poorly soluble or insoluble compounds, however, the impact of dimethyl sulfoxide (DMSO), methanol, and ethanol after acute administration is not well characterized. Here we investigated the impact of 30-min exposures of DMSO, methanol, and ethanol (0.01%, 0.1%, and 1.0% vol/vol) on 5-day old larval zebrafish locomotion and startle responses. …”

Fig 1 - by Taehyeong Kim (8991383)

“…</b> Distribution of P-value and correlation for all modules, samples, and regions. We have 51 highly correlated modules (32 positive and 19 negative correlation) by the criteria (P-value < 0.05 and |correlation coefficient value|>0.5) <b>c</b>. …”

The <em>pch2Δ</em> Mutation in Baker's Yeast Alters Meiotic Crossover Levels and Confers a Defect in Crossover Interference by Sarah Zanders (261652)

“…Third, crossovers observed in <em>pch2Δ</em> require both Msh4-Msh5 and Mms4-Mus81 functions. Lastly, the <em>pch2Δ</em> mutation decreases spore viability and disrupts crossover interference in <em>spo11</em> hypomorph strains that have reduced levels of meiosis-induced double-strand breaks. …”

Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis by Çağatay Tarhan (12657640)

“…Here, we compared the gene expression profiles in Schizosaccharomyces pombe mid-log-phase cells grown in three different Synthetic Dextrose media with 3%, 5%, and 8% glucose, using the RNA sequencing method. …”

The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells by Hanjun Guan (772609)

“…In insulinoma cells when pitrilysin expression was decreased to 5% of normal levels, there was a 60% increase in islet amyloid polypeptide-induced apoptosis. …”