Efficacy and safety of saxagliptin in combination with insulin in Japanese patients with type 2 diabetes mellitus: a 16-week double-blind randomized controlled trial with a 36-week... by Takashi Kadowaki (35402)

“…</p> <p><b>Research design and methods</b>: We randomized 240 patients with type 2 diabetes mellitus on insulin monotherapy to 5-mg saxagliptin or placebo as add-on therapy for a 16-week, double-blind period. …”

IL-7 producing immunotherapy improves <i>ex vivo</i> T cell functions of immunosenescent patients, especially post hip fracture by Chrystel Marton (9950893)

“…We assessed the impact of this encoded hIL-7 on the <i>ex vivo</i> immune functions of T cells from PBMC of immunosenescent patients with or without hip fracture. …”

Table_2_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Table_4_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Dengue in northeastern Brazil: a spatial and temporal perspective by Ana Beatriz Souza Martins (10372760)

“…The AAPC reduced over time (-9.5%; 95% confidance interval [CI]: -18.3; -0.3). …”

Table_1_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Data_Sheet_1_RNA Binding by the Campylobacter jejuni Post-transcriptional Regulator CsrA.pdf by Faiha M. El Abbar (7143620)

“…We performed saturating site-directed mutagenesis on C. jejuni CsrA and assessed the regulatory activity of these mutant proteins, using a reporter system encoding the 5′ untranslated region (5′ UTR) upstream of flaA linked translationally to the C. jejuni astA gene. …”

Total neutrophil and total macrophage concentrations for inflammatory mediator inhibition at different time points. by Sridevi Nagaraja (833270)

“…<p>Green and red lines represent model predictions for acute and chronic inflammation, respectively. We simulated chronic inflammation by increasing the initial platelet concentration by 100 fold, increasing the macrophage influx rate parameter by 1.5 fold, and simultaneously decreasing the platelet degradation rate parameter by 1.5 fold. …”

Table 2_Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.docx by Mallory A. Perry-Eaddy (20842868)

“…</p>Results<p>New functional morbidity occurred in 38 children (32%) and was associated with increased plasma levels of interleukin (IL)-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, and IL-2r and decreased RANTES (CCL5) (p < .001) at all three timepoints. …”

Data Sheet 1_Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis.zip by Dongmei Yuan (291583)

“…In the GPL metabolism and AA metabolism pathways, the transcription levels of genes such as phospholipase A2 (PLA2) family enzymes, cyclooxygenase-2 (Cox-2), arachidonate 5-lipoxygenase (Alox5), and hematopoietic prostaglandin D synthase (Hpgds), all of which regulate phospholipid hydrolysis and lipid mediator production, were significantly increased. …”

Table_6_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Image_3_HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection.pdf by Alan Messala A. Britto (6209393)

“…HPV infected patients expressed higher levels of TLR9 and lower levels of pattern recognition receptors that recognize RNA (TLR3, TLR7, and MDA5/IFIH1). We also detected an impaired IFN pathway, with an increased Type I IFN and a decreased IFNα2 receptor expression. …”

Data_Sheet_1_The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study Wit... by Tiep K. Nguyen (9671153)

“…<p>Staphylococcus aureus may cause relapsing infections. We previously showed that S. aureus SH1000 surviving intracellularly to bactericidal antibiotics are persisters. …”

Using High-Resolution Future Climate Scenarios to Forecast <i>Bromus tectorum</i> Invasion in Rocky Mountain National Park by Amanda M. West (693736)

“…An ensemble of six future climate scenarios indicated the habitable area of <i>B. tectorum</i> may increase from approximately 5.5% currently to 20.4% of the Park by the year 2050. …”

Trend analysis of major cancer statistics according to sex and severity levels in Korea by Minsu Ock (3109788)

“…Among the five cancers affecting both sexes, sex-related differences in 5-year observed survival rates for lung cancer were greatest in the localized stage (men, 31.9%; women, 48.1%), regional stage (men, 20.0%; women, 31.3%), and unknown stage (men, 24.3%; women, 37.5%). …”

Amphiphobic Polytetrafluoroethylene Membranes for Efficient Organic Aerosol Removal by Shasha Feng (2573317)

“…We use atomic-layer deposition (ALD) to uniformly coat a layer of nanosized ZnO particles onto porous PTFE matrix to increase surface area and then subsequently graft PFDAE with plasma. …”

Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels - Figure 4 by Nicholas E. Banovich (631101)

“…Positive associations (upper right quadrant) indicate that the allele associated with increased PWM score for the TF in question is associated with <i>increased</i> methylation; negative associations (lower left quadrant) indicate that increased PWM score is associated with <i>decreased</i> methylation. We used a random set of SNPs in DNase I hypersensitive sites (DHSs) to indicate the expected baseline. …”

Image_1_HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection.pdf by Alan Messala A. Britto (6209393)

“…HPV infected patients expressed higher levels of TLR9 and lower levels of pattern recognition receptors that recognize RNA (TLR3, TLR7, and MDA5/IFIH1). We also detected an impaired IFN pathway, with an increased Type I IFN and a decreased IFNα2 receptor expression. …”

Supplementary Material for: Oral Immunotherapy in Japanese Children with Anaphylactic Peanut Allergy by Nagakura K. (3610526)

“…After 2 years, the median peanut-specific IgE had significantly decreased (from 38.5 to 12.4 kUA/L) in the OIT group, but not in the control group. …”

Data_Sheet_3_Plasma Oxylipins: A Potential Risk Assessment Tool in Atherosclerotic Coronary Artery Disease.docx by D. Elizabeth Le (10678956)

“…<p>Background: While oxylipins have been linked to coronary artery disease (CAD), little is known about their diagnostic and prognostic potential.</p><p>Objective: We tested whether plasma concentration of specific oxylipins may discriminate among number of diseased coronary arteries and predict median 5-year outcomes in symptomatic adults.…”