BT9 exhibits a dose- and time-dependent cytotoxic effect on medulloblastoma. by Zahra Motahari (6814013)

Medium-Ring Keto Bislactams with Antischistosomal Activity by Rongguo Ren (2943366)

“…We discovered medium-ring keto bislactams as a new antischistosomal chemotype. …”

The total muscle and motor unit capacities for initial target forces of 15, 50 and 85% until total muscle capacity decreased to 15% MVC (ie. 85% muscle fatigue for each trial). by Jim R. Potvin (4062412)

SAA in a 50 year-old woman with HHT and severe liver involvement. by Jacques Sellier (8351355)

The Anion [Mg₆Cl₈Cp*₅]^-:  A Final Intermediate on the Way to the Molecular Donor-Free Grignard Compound MgClCp*? by Jean Vollet (2644651)

“…The reaction at −70 °C of decamethylmagnesocene MgCp*₂ (Cp* = pentamethylcyclopentadienyl) with monovalent aluminum chloride, AlCl, stabilized with diethyl ether and dissolved in toluene, results in tetrameric tetrahedrotetrakis(pentamethylcyclopentadienylaluminum), [AlCp*]₄, and the dimeric bis(pentamethylcyclopentadienylmagnesium chloride diethyl etherate), [MgCp*Cl·Et₂O]₂. At a slightly higher temperature and by stepwise decrease of the diethyl ether concentration before reaction, a preferred formation of metal clusters such as dodekakispentamethylcyclopentadienylpentaconta-aluminum, Al₅₀Cp*₁₂, was frequently observed. …”

Dynamic of prolactin in pregnant women during pregnancy. by Francois Kiemde (5369657)

“…Code: *: <0.05; **: <0.01; ***: <0.001; ****: <0.0001. 30μl of plasma was used to determine the concentration of prolactin in blood (ng/ml). Prolactin levels were compared between multigravidae and primigravidae at each scheduled visits as described in “Method” section and presented as box and whisker plots illustration: top, bottom and middle of box, representing 25^th, 75^th and 50^th percentiles, respectively. …”

Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant <i>S. aureus</i> (MRSA) Infections by Targeting Diapop... by Youxin Wang (153032)

“…In our previous work, diapophytoene desaturase (CrtN) was identified to be an attractive and drugable target for fighting pigmented <i>S. aureus</i> infections. In this research, we developed a series of effective benzocycloalkane-derived CrtN inhibitors with submicromolar IC₅₀. …”

Inhibition of IL-6 Signaling Pathway by Curcumin in Uterine Decidual Cells by Y. Sangeeta Devi (737137)

“…To further understand whether NF-ҡB is involved in this inhibition, we examined the effect of curcumin on the expression of p50 and p65 subunits of NF-ҡB in decidual cells. …”

Decreases in muscle size, muscle force, and TB mass in 3-mo Lmna^HSA-cko mice. by Lei Xiong (334812)

Density Functional Study on Compounds to Accelerate the Electron Capture Decay of ⁷Be by Akira Yoshida (392232)

“…Thus, the decay can be accelerated by changing the chemical or physical conditions. A previous study reported a 1.1–1.5% reduction in the half-life of ⁷Be encapsulated in C₆₀ compared with ⁷Be metal. …”

IL-17A inhibits apoptosis of OCPs. by Hao Tang (44155)

IL-17A promotes RANKL-stimulated osteoclastogenesis. by Hao Tang (44155)

Inhibition of autophagy attenuates IL-17A-mediated osteoclastogenesis. by Hao Tang (44155)

Lysine 50 of Tat regulates expression of C5, CRLF2, APBA1, and BDNF genes. by Loreto Carvallo (4167607)

“…<p>THP-1Tat-Flag and THP-1Tat K50ATat-Flag cell lines (generated from independent experiments described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179882#pone.0179882.g005" target="_blank">Fig 5</a>) were differentiated to macrophages with PMA for 24 and 48 hours. …”

Activation of NMDA receptors with D-serine obviously limited the decrease of p-CREB in the hippocampus of the surviving LPS-treated mice. by Shuibing Zhang (4336402)

Treatment with con-G showed improved neurological scoring and decreased peri-infarct Ca²⁺ microdeposits. by Rashna Balsara (714796)

Nicotine decreased Akt phosphorylation in SK-BR-3 cells. by Masanori A. Murayama (5774585)

DataSheet1_The antimicrobial peptide Esc(1-21)-1c increases susceptibility of Pseudomonas aeruginosa to conventional antibiotics by decreasing the expression of the MexAB-OprM effl... by Carolina Canè (17274244)

(A) Decreasing CaMKII activity by KN-93 (high-3 µmol/L, low-0.5 µmol/L), AIP (high-10 µmol/L, low-2 µmol/L), or decreasing calmodulin activity by W-7 (high-50 µmol/L, low-20 µmol/L) decreases spontaneous AP firing rate (n = 10 for each drug), cAMP (n = 4 for each drug) and ATP (n = 5 for each drug). by Yael Yaniv (162548)

Synthesis and Activity of a Novel Autotaxin Inhibitor–Icodextrin Conjugate by Natalie Fisher (1860283)

“…The conjugate inhibits autotaxin activity (IC₅₀ = 0.86 ± 0.13 μg mL^–1) and reduces cell migration. …”