Impact of Environment and Social Gradient on <em>Leptospira</em> Infection in Urban Slums by Renato B. Reis (90436)

“…</p><h3>Methods and Findings</h3><p>We performed a community-based survey of 3,171 slum residents from Salvador, Brazil. …”

Lovastatin in combination with VEGFR-2 TKIs inhibits ligand induced activation of AKT, S6K1 and 4EBP1. by Tong T. Zhao (361937)

“…All cells were then lysed after stimulation with 50 ng/ml VEGF₁₆₅ for 30 min. Results demonstrated that lovastatin in combination with KRN633 induced the most significant decrease in phosphorylation status of all three proteins in H28 cells. …”

File S1 - <i>FGFR2</i> Is Amplified in the NCI-H716 Colorectal Cancer Cell Line and Is Required for Growth and Survival by Anjili Mathur (163690)

“…</b> Lysates were processed as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098515#pone-0098515-g001" target="_blank">Figure 1A</a>. “+” indicates addition of 50 ng/ml FGF2 for 15 minutes. …”

Low doses of IL-4 and IL-13 enhance cellular proliferation. by Quentin D’Arcy (13919516)

“…<p><b>A, B.</b> N1 and SFT1 prostate fibroblasts and HLF primary lung fibroblasts were cultured in serum-free defined media supplemented with vehicle or increasing doses (1–100 ng) of human recombinant IL-4 (<b>A</b>) or IL-13 (<b>B</b>) for 24 hours. …”

Effects of treatment with mTORC1 blocker rapamycin on taste cells. by Shingo Takai (7853843)

“…<p>(A, B) Confocal images of taste organoids at day 20, cultured in conditioned medium (CM) with 20 ng/ml rapamycin plus 50 nM insulin (A) or 0 nM insulin (B). …”

Tacrolimus and MPA can inhibit signaling pathway activation in whole-blood samples. by Nynke M. Kannegieter (3697594)

“…Blood samples from healthy volunteers were spiked with vehicle, 10 ng/ml tacrolimus, 50 ng/ml tacrolimus, 200 ng/ml tacrolimus, 10 μg/ml MPA or 20 μM of the MAPK inhibitor SB203580. …”

<b>Supporting data for ''The pathogenicity and pathogenic mechanism of SARS-CoV-2 Omicron''</b> by Bingjie Hu (10835565)

Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution by Oliver Grottke (584154)

“…Idarucizumab was then administered intravenously (30 mg/kg) and serial blood samples were taken for up to 24 hours to measure diluted thrombin time (corresponding with dabigatran activity), total dabigatran (bound to antidote and free drug) and a panel of coagulation parameters.</p><p>Results</p><p>Mean plasma dabigatran levels were 617 ± 16 ng/mL after infusion and 600 ± 114 ng/mL after ~50% hemodilution with no significant differences between groups. …”

Data collected during an investigation into uncertainty and impressions among people. by Zhijie Xie (9125206)

“…Using data collected in online surveys and psychology laboratory, we found that participants optimistically perceived the 50% acceptance probability, and that uncertainty enhances the impression of a target who has a 50% acceptance probability. …”

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations by Mathew J. Barber (251595)

“…<div><h3>Background</h3><p>Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies among individuals. To identify single nucleotide polymorphisms (SNPs) contributing to this variation, we performed a combined analysis of genome-wide association (GWA) results from three trials of statin efficacy.…”

Data_Sheet_1_Ginsenoside Rg2 Ameliorates Myocardial Ischemia/Reperfusion Injury by Regulating TAK1 to Inhibit Necroptosis.pdf by Yao Li (154923)

“…In vivo, male C57/BL6 mice were subjected to myocardial ischemia 30 min/reperfusion 4 h. Rg2 (50 mg/kg) or vehicle was intravenously infused 5 min before reperfusion. …”

Supporting datasets for all figures. by Matthew Drill (22258391)

“…This reduction in tumour cell number was concentration-dependent, modelled by a least squares linear regression (R² = 0.8221, IC50 = 17µM). …”

The purificated IgG against the R32 and R72 peptides reduced the level of PRA. by Zhihua Qiu (426776)

“…The PRA was significantly decreased by 50% in the R32 and hR72 groups, while no obvious change in the R215 groups. …”

Data_Sheet_1_Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies.pdf by Eli Hatchwell (8584452)

“…</p>Conclusion<p>For the first time, a PML genetic risk test can be implemented for screening patients taking or considering treatment with a PML-linked drug in order to decrease the incidence of PML and enable safer use of highly effective therapies used to treat their underlying disease.…”

Presentation1_Pulmonary nitric oxide in astronauts before and during long-term spaceflight.pdf by Lars L. Karlsson (17875562)

“…</p><p>Results: The levels of PENO at 50 mL/s (PENO50) were not stable during the preflight and inflight periods respectively but decreased with time (p = 0.0284) at a rate of 0.55 (0.24) [mean (SD)] mPa per 180 days throughout the observation period, so that there was a significant difference (p < 0.01, N = 10) between gravity conditions. …”

Hyperbaric oxygen therapy and comprehensive orthopedic treatment for incomplete traumatic spinal cord injury on the Qinghai-Tibet Plateau: study protocol for an open-label randomiz... by Jun Ma (4058161)

“…<div>Background: Apoptosis secondary to ischemia and hypoxia is the main cause of spinal cord dysfunction. Because of the decrease in atmospheric pressure, patients living on the Qinghai-Tibet Plateau are in a hypoxic environment, which is very unfavorable for the recovery of spinal cord injury. …”

Picturing asthma in Turkey: results from the Turkish adult asthma registry by Gulfem Elif Celik (16000130)

Parallel activation of ERK2 and JNK1 contributes to TNF-α-induced IL-8 expression. by Shinichi Namba (3350288)

“…<p>(A) Expression of phosphorylated JNK1 (p-JNK1), total JNK1 (t-JNK1), phosphorylated ERK2 (p-ERK2), total ERK2 (t-ERK2), and β-actin were detected by western blotting in cells transfected with ERK2 siRNA and subsequently stimulated with or without TNF-α (50 ng/mL) for 15 min (upper panel). β-actin was used as an internal standard. …”

Table_1_Stable carbon isotopes of dissolved inorganic carbon in the Western North Pacific Ocean: Proxy for water mixing and dynamics.pdf by Tiantian Ge (292883)

“…We found a strong ¹³C Suess Effect in the upper 2,000 m in the western NP Ocean, and δ¹³C-DIC at the surface (<50 m) has decreased by 0.60‰-0.85‰ since 1993. …”

Highly Flexible and Conductive Cellulose-Mediated PEDOT:PSS/MWCNT Composite Films for Supercapacitor Electrodes by Dawei Zhao (662345)

“…Another kind of MCPP-based solid-state supercapacitor without the Ni foam showed excellent flexibility and a high volumetric capacitance of 50.4 F cm^–3 at 0.05 A cm^–3. …”