Image_4_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Data_Sheet_1_Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States.pdf by Ning Cao (158319)

Gene expression profiles in wildtype and <i>Tnfr1,2-</i>deficient glomeruli after TNF stimulation ex vivo. by Anela Taubitz (433585)

“…<p>Expression profiling by microarrays was performed on isolated glomeruli from wildtype and <i>Tnfr1,2</i>−/− mice 12 after stimulation with 50 ng/ml TNF for 12 hours ex vivo. A negativ “fold change” (black to green) indicates decreased expression and a postive “fold change” (black to red) indicates increased expression in a glomerular sample compared with the average of all analyzed samples. …”

Manipulation of reward gradient in Experiment 1. by Harry Manley (516006)

Data_Sheet_1_Effects of Different Grazing Disturbances on the Plant Diversity and Ecological Functions of Alpine Grassland Ecosystem on the Qinghai-Tibetan Plateau.docx by Wenlong Li (571749)

“…Aboveground biomass (AGB) and belowground biomass (BGB) decreased, respectively, by 41.91% (95% CI: −50.91 to −32.88%) and 17.68% (95% CI: −26.94 to −8.52%). …”

Data Sheet 1_Blue light modulates the interactive effects of far-red light and day–night temperature difference on the growth, morphology and physiology of arugula and lettuce.docx... by Awais Ali (8613051)

“…Morphological acclimation, such as thinner leaves under FR light and +DIF, led to a decrease in single-leaf daily carbon gain, whereas high blue light improved daily carbon gain by enhancing leaf thickness and pigment levels. …”

Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection by Emmanouil Papasavvas (5406)

“…Based on these findings, we suggest that further clinical research on the long-term consequences of TI strategies to decrease drug exposure is warranted.…”

IL-4 induced CCL26 expression is inhibited by PLAG. by Jinseon Jeong (2579929)

“…<p>(A) A549 cells were treated with various doses of PLAG (1, 5, 10, 50 μg/mL) for 1 h and stimulated with IL-4 (10 ng/mL) for 24 h. …”

E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy by Jennifer L. Major (3639472)

“…Using the Seahorse platform, a 22% decrease in glycolysis was noted in neonatal cardiomyocytes isolated from E2F6-Tg hearts. …”

presentation1_Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients.pptx by Huanhuan Wang (309941)

“…Model-based simulations showed that the SOFA score on day 7 decreased to a plateau when AUC increased to 1,500 h*ng/mL.…”

datasheet1_Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients.docx by Huanhuan Wang (309941)

“…Model-based simulations showed that the SOFA score on day 7 decreased to a plateau when AUC increased to 1,500 h*ng/mL.…”

20-HETE increases murine airway sensitivity to carbachol. by Philip R. Cooper (188104)

“…Incubation with 20-HETE (B) decreased log EC₅₀ values; but, (C) had no effect on maximum contraction compared to control slices. …”

Multiple pathways of alveolar macrophage death contribute to pulmonary inflammation induced by silica nanoparticles by Eun-Jung Park (201821)

“…In this study, we tried to clarify the causes of different responses induced by both SiNPs using mice (12.5, 25, and 50 μg/lung) and mouse alveolar macrophage cells. …”

Table_1_Do changes in working hours increase stress in Japanese white-collar workers?.DOCX by Masaki Ozawa (2354584)

“…</p>Results<p>We observed a greater increase in stress among female who worked 41–50 h per week at T1 and more than 50 hours per week at T2, and those who worked more than 50 h per week at T1 and 35–40/41–50 h per week at T2, compared to those who worked 41–50 h per week both at T1 and T2, with odds ratios (ORs) and 95% confidence intervals (95% CI) of OR = 2.09, 95% CI (1.18, 3,70); OR =1.86, 95% CI (1.14, 3.03), respectively. …”

Toll signaling in the Drosophila larval fat body shifts programs of anabolic lipid metabolism and dysregulates nutrient storage by Brittany Martínez (8728753)

“…However, we observe 50% decreases in fat body transcript levels of both <i>lipin</i>, a phosphatidic acid phosphatase,<i> </i>and<i> midway, </i>the homolog of diacylglycerol acyltransferase, both of which carry out triglyceride synthesis. …”

NGF accelerates nuclear trafficking of FGFR1 by reducing FGFR1 nuclear export. by Yu-Wei Lee (432337)

“…Twenty-four hours after transfection, cultures were treated with 50 ng/ml NGF and LMB (100 ng/ml in 0.1% v/v ethanol) or ethanol alone (0.1% v/v ethanol) for an additional 48 h and during subsequent imaging. …”

DsRNA() delivery for PTGS of expression by Ji Hyun Yang (16591)

“…To evaluate an optimum complex formation, various concentrations of POA were mixed with a fixed concentration of dsRNA () (lane 1, 100 ng of dsRNA only; lanes 2–9, 12.5, 25, 37.5, 50, 62.5, 75, 87.5 and 100 ng of POA mixed with 100 ng of dsRNA, respectively). …”

GM-0111 prevents multinucleated giant osteoclast formation. by Justin R. Savage (478023)

“…<p>Mouse bone marrow derived pre-osteoclast cells cultured with M-CSF (50 ng/mL) and RANKL (25 ng/mL) transformed into TRAP-positive MNGCs in 4 days (<b>A</b>). …”

Fiber Pathway Pathology, Synapse Loss and Decline of Cortical Function in Schizophrenia by Max R. Bennett (400383)

“…There is also a 50% decrease in measured cortical activity following inactivation of the nucleus of Meynert and the intra-laminar nuclei of the thalamus, which arise either following appropriate lesions or in sleep. …”

Data_Sheet_1_The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.PDF by Marta Canuti (336637)

“…The proportion of immune suppressed patients among all hospitalizations (initially stable at <20%) started to increase around December 2021, and remained high (30–50%). This change coincided with an increase in the proportions of older patients and patients with co-morbidities and with a decrease in the proportion of patients with severe outcomes. …”