mTORC1 hyperactivation led to a decreased autophagic activity in the podocytes. by Wakiko Iwata (8600457)

“…<p>(<b>A</b>) Primary cultured podocytes were isolated from <i>Tsc2</i>^{Δ<i>podocyte</i>} and wild-type controls, followed by western blot analyses of TSC2, phospho-4EBP1, LC3B type II, p62, phospho-ULK1, and β-tubulin. …”

SRPO significantly decreased leukocyte-endothelial interactions and serum MCP-1 level. by Hiroshi Kataoka (270804)

Split <i>ClvR</i>^<50cM configurations. by Georg Oberhofer (3401438)

Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules by Kimberly A. D. Gregersen (2241349)

“…We demonstrate this method with the intracellular release of the second messenger IP₃ in CHO-M1 cells and report that calcium responses from the cells changed from a sustained increase to a transient spike when the average number of IP₃ released is decreased below 50 molecules per nanocapsule. …”

Decreased production of highly reactive oxygen species production induced by complement-mediated phagocytosis in Rab27a-knockdown cells. by Tatsumi Kawakami (505540)

Nitrogen nutrition is a key modulator of the sugar and organic acid content in citrus fruit by Ling Liao (385468)

“…Sucrose and ascorbic acid content increased (8.46 to 50.97 mg g^-1 and 8.16 to 27.39 mg g^-1, respectively), while citric acid content decreased (90.81 to 0.02 mg g^-1). …”

BT9 exhibits a dose- and time-dependent cytotoxic effect on medulloblastoma. by Zahra Motahari (6814013)

Interaction strength in plant-pollinator networks: Are we using the right measure? by Roberto Novella-Fernandez (8119745)

The inhibitory activity of the most active compounds against Glo-I enzyme with less than 50 µM. Their supportive corresponding docking values on two different protocols are display... by MohammedBashar Al-Qazzan (22439236)

Elemental analysis shows a decreased N content in N stressed cells without a change in their C content. by Steve Dagenais Bellefeuille (654383)

DataSheet_1_Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells.pdf by Chao Gu (402478)

“…Dectin-1 stimulation induced STAT3 activation and decreased the transcriptional activity of p50-RelB, both of which resulted in reduced OX40L expression on TSLP-activated mDCs. …”

Medium-Ring Keto Bislactams with Antischistosomal Activity by Rongguo Ren (2943366)

“…We discovered medium-ring keto bislactams as a new antischistosomal chemotype. …”

The Anion [Mg₆Cl₈Cp*₅]^-:  A Final Intermediate on the Way to the Molecular Donor-Free Grignard Compound MgClCp*? by Jean Vollet (2644651)

“…The reaction at −70 °C of decamethylmagnesocene MgCp*₂ (Cp* = pentamethylcyclopentadienyl) with monovalent aluminum chloride, AlCl, stabilized with diethyl ether and dissolved in toluene, results in tetrameric tetrahedrotetrakis(pentamethylcyclopentadienylaluminum), [AlCp*]₄, and the dimeric bis(pentamethylcyclopentadienylmagnesium chloride diethyl etherate), [MgCp*Cl·Et₂O]₂. At a slightly higher temperature and by stepwise decrease of the diethyl ether concentration before reaction, a preferred formation of metal clusters such as dodekakispentamethylcyclopentadienylpentaconta-aluminum, Al₅₀Cp*₁₂, was frequently observed. …”

SAA in a 50 year-old woman with HHT and severe liver involvement. by Jacques Sellier (8351355)

The total muscle and motor unit capacities for initial target forces of 15, 50 and 85% until total muscle capacity decreased to 15% MVC (ie. 85% muscle fatigue for each trial). by Jim R. Potvin (4062412)

Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant <i>S. aureus</i> (MRSA) Infections by Targeting Diapop... by Youxin Wang (153032)

“…In our previous work, diapophytoene desaturase (CrtN) was identified to be an attractive and drugable target for fighting pigmented <i>S. aureus</i> infections. In this research, we developed a series of effective benzocycloalkane-derived CrtN inhibitors with submicromolar IC₅₀. …”

Inhibition of IL-6 Signaling Pathway by Curcumin in Uterine Decidual Cells by Y. Sangeeta Devi (737137)

“…To further understand whether NF-ҡB is involved in this inhibition, we examined the effect of curcumin on the expression of p50 and p65 subunits of NF-ҡB in decidual cells. …”

Density Functional Study on Compounds to Accelerate the Electron Capture Decay of ⁷Be by Akira Yoshida (392232)

“…Thus, the decay can be accelerated by changing the chemical or physical conditions. A previous study reported a 1.1–1.5% reduction in the half-life of ⁷Be encapsulated in C₆₀ compared with ⁷Be metal. …”

Decreases in muscle size, muscle force, and TB mass in 3-mo Lmna^HSA-cko mice. by Lei Xiong (334812)

Lysine 50 of Tat regulates expression of C5, CRLF2, APBA1, and BDNF genes. by Loreto Carvallo (4167607)

“…<p>THP-1Tat-Flag and THP-1Tat K50ATat-Flag cell lines (generated from independent experiments described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179882#pone.0179882.g005" target="_blank">Fig 5</a>) were differentiated to macrophages with PMA for 24 and 48 hours. …”