Table 6_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Table 4_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Image 1_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Image 5_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Table 1_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Image 6_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Expression of <i>PAX</i> genes and MRFs during G₀ entrance (SM), exit (GM) and differentiation (DM). (A) <i>PAX3</i> and <i>PAX7</i> expression levels were high in G<sub... by Jeeva Sellathurai (399773)

“…After 6 h in SM only 2.5% (±1.1 SEM) of the cells were MYOGENIN positive and the fraction decreased further during culture in SM with a tendency for an increase up to 2.8% (±2.0 SEM). …”

Synthesis and Decomposition of Alkyl Complexes of Molybdenum(IV) That Contain a [(Me₃SiNCH₂CH₂)₃N]^3- Ligand. Direct Detection... by Richard R. Schrock (1295601)

“…Below ∼50 K the effective moments undergo a sharp decrease as a consequence of what are proposed to be a combination of spin−orbit coupling and zero field splitting effects. …”

Annual fluxes (kg N ha⁻¹ yr⁻¹) as total dissolved nitrogen, N-NH₄⁺, N-NO₃⁻ and dissolved organic nitrogen and effe... by Li-hua Tu (469843)

“…A positive value indicates the effect is increased, and a negative value indicates the decreased effect.…”

<b>Role of the Chaperone ClpB in</b><b> </b><b>Mycoplasma bovis</b><b> Virulence: Implications for </b><b>stress response, a</b><b>dhesion, </b><b>b</b><b>iofilm </b><b>d</b><b>eve... by Hui zhang (22187170)

“…<p dir="ltr">ClpB, an ATP-dependent molecular chaperone belonging to the Hsp100/Clp subfamily of AAA+ ATPases, plays a crucial role in protein disaggregation, thereby enhancing bacterial survival under stress conditions. …”

Propagation of the DMI signal into flanking regions in simulated data (sampled at generation 30, significance threshold: <i>X</i>(2)<−0.005 & <i>D’</i><0) when only homozygous geno... by Juan Li (146180)

“…To resemble the demography of the studied hybrid swordtail fish populations, the admixture proportion was set to <i>f</i> = 0.3 and the migration rate was <i>m</i> = 0.01. 200 individuals were sampled from each simulation to obtain the statistics. A. The number of significant marker pairs decreases rapidly with distance to the nearest true DMI locus. …”

HMGB1 increases endothelial cell permeability. by Mengchen Zou (725646)

“…<p>A. HMGB1-induced TEER decrease. EA.hy926 cells cultured on transwell filters were incubated for 3, 6, 12, 24, 36 and 48h, respectively, with or without 50, 100, 200 and 400 ng/ml HMGB1. …”

Synaptic efficacy is reduced during UP states. by Brendon O. Watson (268774)

“…In purple are EPSP percent changes for 4 recorded interneurons, which show heterogeneous changes during the UP state ranging from a 30% increase to a 65% decrease (mean: 26.5% decrease, standard deviation 50.0%; see gray bar at left of graph). …”

The effect of Andro alone or in combination with Taxi on MMP loss in HeLa cells. by Mazen Alzaharna (3737878)

“…(E) A representative flow cytometric histograms showing the loss in MMP (decrease in FL2 fluorescence) in HeLa cells treated with 50 μM Andro and/or 100 μM Taxi for 24 or 48 h and stained with JC-1. …”

Family History of Hypertension Impairs the Autonomic Balance, but not the Endothelial Function, in Young Soccer Players by Walter Vargas (6798635)

“…Results The standard deviation of normal RR intervals (SDNN; FM-N=314±185; FM-H=182.4± 57.8), the square root of the mean squared differences in successive RR intervals (RMSSD; FM-N=248±134; FM-H=87±51), the number of interval differences of successive NN intervals greater than 50ms (NN50; FM-N=367±83.4; FM-H=229±55), the ratio derived by dividing NN50 by the total number of NN intervals (pNN50; FM-N=32.4±6.2; FM-H=21.1±5.3) and the high (HF; FM-N=49±8.9; FM-H=35.3±12) and low-frequency (LF; FM-N=50.9±8.9; FM-H=64.6±12) components, in normalized units (%), were significantly lower in the FM-H group than in the FM-N group (p<0.05). …”

Cell counts in different retinal layers for zebrafish exposed to MNU at baseline and follow-up. by Christoph Tappeiner (444164)

“…<p>A. MNU 50 mg/l group: No relevant decrease in retinal cells was observed (p>0.05). …”

Palmitate-induced cell death is enhanced by RSV. by Cristina Rojas (667363)

“…Palmitate-treated cells were also co-incubated with increasing concentrations of RSV as follows: <b>B</b>) 25 µM RSV; <b>C</b>) 50 µM RSV and <b>D</b>) 100 µMRSV. A further decrease on HepG2 viability compared with treatments with palmitate alone was observed in the 50 µM RSV and 100 µM RSV assays. …”

Dopamine depletion increases intrinsic excitability of medium spiny neurons. by Karima Azdad (370732)

“…(D) Summary histogram of the mean first spike latency at the 120 pA current pulse illustrating the decrease of the first spike latency induced by dopamine depletion. …”