Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Loss of Runx1 in <i>mdx</i> mice decreases muscle mass, muscle strength and lifespan. by Kfir Baruch Umansky (783699)

Summary plot for the effect of important food sources of fructose-containing sugars on systolic blood pressure (SBP). by Qi Liu (33068)

Corneal nerves demonstrate delayed and decreased HSV-1 infection in conventional dendritic cell-depleted corneas. by Kai Hu (311882)

Local injection of p29 alleviates the reduction in myofiber size by restoration of the decreased numbers of satellite cells. by Yutaka Ohsawa (587120)

Effect of decreased K8 Ser 73 or Ser431 phosphorylation on migratory ability of OSCC cells. by Hunain Alam (103978)

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

Expression and protein level of the extracellular calcium-sensing receptor (CaSR) were decreased in the hypertension groups. by Yuan-yuan Qu (446755)

Decreased E/I synapse ratio and loss of cortico-LA synaptic plasticity in the absence of coronin 1. by Rajesh Jayachandran (542641)

“…Scale bars, 100 pA and 20 ms. See <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001820#pbio.1001820.s018" target="_blank">Table S1</a> for additional statistics.…”

Image_1_Acclimation of Photosynthesis to Changes in the Environment Results in Decreases of Oxidative Stress in Arabidopsis thaliana.JPEG by Mohd Fauzihan Karim (11470027)

Image_2_Acclimation of Photosynthesis to Changes in the Environment Results in Decreases of Oxidative Stress in Arabidopsis thaliana.JPEG by Mohd Fauzihan Karim (11470027)

Table_1_Acclimation of Photosynthesis to Changes in the Environment Results in Decreases of Oxidative Stress in Arabidopsis thaliana.DOCX by Mohd Fauzihan Karim (11470027)

Down-regulation of NNMT expression decreased the plate efficiency and attenuated the capacity of colony formation in soft ager by Jun Zhang (48506)

Taurine Chloramine decreases cell viability and cytokine production in blood and spleen lymphocytes from septic rats by DHÉBORA M. DALL’IGNA (10365522)

“…Lymphocytes were cultured at a concentration of 1×106 cells/mL and activated by concanavalin A. …”

S100A1 can interfere with the interaction between p53 and MDM2/MDMX. by Deepu Dowarha (5673440)

Subjects:

Animation displaying S100A1−MDM2 complex generated via the HADDOCK program. by Deepu Dowarha (5673440)

Subjects:

Filamentation induced by DTPA is associated with a decrease in Nrg1 protein level, and requires the cAMP-PKA pathway and the kinase Sok1. by Elizabeth J. Polvi (3163500)