<em>Vibrio cholerae</em> Proteome-Wide Screen for Immunostimulatory Proteins Identifies Phosphatidylserine Decarboxylase as a Novel Toll-Like Receptor 4 Agonist by Ann Thanawastien (260657)

“…In order to identify novel bacterial immunostimulatory proteins, we developed a new high-throughput approach called “EPSIA”, <b><em>E</em></b>xpressed <b><em>P</em></b>rotein <b><em>S</em></b>creen for <b><em>I</em></b>mmune <b><em>A</em></b>ctivators. …”

Impact of BLASTn percent identity threshold on detection of species-biased probes between platforms. by Gabriel A. Preising (11534682)

“…<i>nilocitus</i>, the overlaps of aCGH with sequencing platforms increase as we lower the BLASTn threshold while the overlaps of sequencing platforms with aCGH decrease. …”

Computational modelling predicts substantial carbon assimilation gains for C₃ plants with a single-celled C₄ biochemical pump by Ivan Jurić (7444847)

“…However, at higher permeabilities the C₄ pathway still provides a substantial boost to carbon assimilation with only a moderate decrease in efficiency. …”

<i>In vivo</i> luciferase assay study of HepG2 cells co-transfected with the reporter plasmids and different concentrations of miR-181a. by Jane Yi Lin Tan (728488)

“…However, as compared to the control, miR-181a shows a significantly stronger binding to both the plasmids containing the 3’UTRs of CDKN1β and E2F7, with a further decrease in firefly luciferase activity by about two times when transfected with 10nM miR-181a and up to six times when transfected with 100nM miR-181a, as compared to when transfected with the control reporter plasmid.…”

DataSheet1_A Sediment Magnetic Record in the North Pacific Across the Mid-Pleistocene Transition and its Implication on Asian Dust Evolution.docx by Ji Young Shin (9136598)

“…The detrital magnetic component is characterized by high coercivity (>100 mT) and shows a long-term increase in concentration since ∼1 Ma. …”

Table_1_Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.docx by Jose Manuel Sánchez-Maldonado (11611801)

“…<p>We aimed to validate the association of 28 GWAS-identified genetic variants for response to TNF inhibitors (TNFi) in a discovery cohort of 1361 rheumatoid arthritis (RA) patients monitored in routine care and ascertained through the REPAIR consortium and DANBIO registry. …”

Table_3_Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.xlsx by Jose Manuel Sánchez-Maldonado (11611801)

“…<p>We aimed to validate the association of 28 GWAS-identified genetic variants for response to TNF inhibitors (TNFi) in a discovery cohort of 1361 rheumatoid arthritis (RA) patients monitored in routine care and ascertained through the REPAIR consortium and DANBIO registry. …”

Table_2_Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.xlsx by Jose Manuel Sánchez-Maldonado (11611801)

“…<p>We aimed to validate the association of 28 GWAS-identified genetic variants for response to TNF inhibitors (TNFi) in a discovery cohort of 1361 rheumatoid arthritis (RA) patients monitored in routine care and ascertained through the REPAIR consortium and DANBIO registry. …”

Table 1_Associations of urinary enterolignans and risk of overall and cause-specific mortality with or without serum albumin adjustment: a prospective cohort study.docx by Zisuo Sun (22310437)

“…Involvement of human serum albumin (HSA) could be a possible reason behind the inconsistency. We prospectively examined the associations between urinary enterolignans and the risk of overall and cause-specific mortality among US adults and evaluated the impact of adjusting for HSA by comparing the results before and after its inclusion as a covariate.…”

Image_1_Effects of the flow diversion technique on nucleotide levels in intra-cranial aneurysms: A feasibility study providing new research perspectives.JPEG by Omer F. Eker (5696639)

“…However, the biological phenomena underlying its efficacy remain unknown. We proposed a method to collect in situ blood samples to explore the flow diversion effect within the aneurysm sac. …”

Cytotoxicity of ExPEC EVs. by Min Jiang (56794)

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study by Bram. P. Prins (3165489)

“…Further, we found that a standardized CRP polygenic risk score (CRP_<i>PRS</i>) at <i>p-</i>value thresholds of 1 × 10⁻⁴, 0.001, 0.01, 0.05, and 0.1 using individual-level data also showed a protective effect (OR < 1.00) against schizophrenia; the first CRP_<i>PRS</i> (built of SNPs with <i>p</i> < 1 × 10⁻⁴) showed a statistically significant (<i>p <</i> 2.45 × 10⁻⁴) protective effect with an OR of 0.97 (95% CI 0.95–0.99). …”

MAP3K19 siRNA inhibits cigarette smoke-induced pulmonary inflammation. by Stefen A. Boehme (2657068)

“…<p>The acute model of cigarette smoke exposure subjected mice to cigarette smoke (7 cigarettes over a 1.75 hour period) on days 1 & 2, and dosed with either PBS, non-sense siRNA (100 μg in 50 μl volume), MAP3K19 siRNA or the CXCR-2 antagonist SB 265610 (10 mg/kg, p.o.) on days 1, 2 & 3 (n = 5 mice per treatment group). …”

RNA-Seq Profiling of a Defective Seed Coat Mutation in <i>Glycine max</i> Reveals Differential Expression of Proline-Rich and Other Cell Wall Protein Transcripts by Anupreet Kour (564197)

“…<div><p>The plant cell wall performs a number of essential functions including providing shape to many different cell types and serving as a defense against potential pathogens. …”

Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG) by Signe Korsgaard Skriver (4613635)

“…Here, we report the results obtained by neoadjuvant letrozole in patients with early breast cancer in a phase-II design.…”

Assessing the usage of end-of-life tire pyrolysis oil as an alternative fuel in a diesel engine in the point of energy, exergy, exergoeconomic, exergoenviroeconomic, and sustainabi... by Talha Ertürk (19715855)

“…<p>The present study examines the utilization of fuel blends comprising waste tire pyrolysis oil (WTPO) at varying ratios (10%, 20%, 30%, and 40%) in a compression-ignition (CI) engine at different loads (25%, 50%, 75%, and 100%). …”

ERR2/3 may in part operate through <i>Kcna10</i> to promote a gamma motor neuron-like biophysical signature. by Mudassar N. Khan (14290428)

“…<b>(C)</b> Reporter tdTomato fluorescence driven by wild-type (WT) <i>Kcna10</i> promoter is boosted by ERR2 cotransfection (red, <i>n</i> = 102) in chick motor neurons when compared to control (gray, <i>n</i> = 100) and decrease in tdTomato reporter fluorescence upon mutating the ERR2/3 binding sites (black, <i>n</i> = 101). …”

Table 2_Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration.xlsx by Meng Yi (7853249)

“…</p>Results<p>Bioinformatics analysis of human data identified three diagnostic biomarkers (S100A12, IL1R1, FCGR2B) and constructed a robust ANN diagnostic model (AUCs: 0.744-0.868). …”

Presentation_1_Altered Lipid Metabolism Impairs Skeletal Muscle Force in Young Rats Submitted to a Short-Term High-Fat Diet.PPTX by David E. Andrich (5791211)

“…Young male Wistar rats (100–125 g) were fed HFD or a regular chow diet (RCD) for 14 days. …”

Table_1_Altered Lipid Metabolism Impairs Skeletal Muscle Force in Young Rats Submitted to a Short-Term High-Fat Diet.DOCX by David E. Andrich (5791211)

“…Young male Wistar rats (100–125 g) were fed HFD or a regular chow diet (RCD) for 14 days. …”