GFP::DAF-16 and DAF-16AM::GFP have similar expression levels. by İçten Meraş (13184380)

Alignment between <i>C</i>. <i>elegans</i> glucose-6-Phosphate translocase ortholog and human, mouse, zebrafish, and fly glucose-6-Phosphate exchanger. by Brian Onken (86790)

Lifespan data. by Brian Onken (86790)

Increased Locomotory Healthspan and Survival with <i>pck-2</i> Overexpression, as Well as Expression of <i>pck-2</i> in the Intestine, Require <i>daf-16</i>. by Brian Onken (86790)

Excess glucose availability negatively impacts healthspan of young and old animals; conversely, the benefits of disrupting glycolysis do not include extended maximal lifespan. by Brian Onken (86790)

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…Trials with 5 and 13 day old animals also showed impaired older age locomotion in 4% glucose (Supplemental <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.s002" target="_blank">S1A and S1B Fig</a>). …”

Gluconeogenic gene <i>fbp-1</i> expression is required for healthspan extension under dietary restriction. by Brian Onken (86790)

Dietary Restriction Induces Gluconeogenic Gene <i>pck-2</i> Expression via DAF-16, and <i>pck-2</i> Expression is Needed for DR-associated Healthspan Benefits. by Brian Onken (86790)

“…Elevated gluconeogenic activity (dependent on DAF-16-promoted PCK-2 expression) acts in a feed-forward capacity to further enhance the gluoconeogenic pathway and may inhibit glycolysis/insulin signaling to promote/maintain DAF-16 signaling and healthy metabolism (inhibition represented by a dashed line).…”

The healthspan effects of glycolytic and gluconeogenic disruptions are absent in the <i>age-1</i> insulin signaling mutant background. by Brian Onken (86790)

The GON domain expression alters dauer formation and longevity. by Sawako Yoshina (375229)

Spatial training decreases endogenous PTEN ubiquitination and <i>Pten</i> cKO mice show impaired spatial learning and memory. by Wei-Lun Hsu (1756123)

“…The <i>Pten</i> cKO mice showed impaired retention performance and made less travelling in the target quadrant than the <i>Pten loxp</i> mice. <b>(G)</b> The PTEN expression level is decreased in the <i>Pten</i> cKO mice than the <i>Pten loxp</i> mice (t_1,16 = 17.96, <i>p</i> < 0.001). …”

Knocking down <i>enok</i> without affecting <i>rhi</i> levels decreased transcript levels from 42AB. by Shih-Ying Tsai (3576587)

Three weeks of high-fat feeding compared to rats on CHOW decreased whole-body insulin sensitivity as assessed by hyperinsulinemic eulgycemic clamp. by Silvie Timmers (357546)

Supplementary Material for: Decreased Toll-Like Receptor 2 and Toll-Like Receptor 7/8-Induced Cytokines in Parkinson's Disease Patients by da Silva D.J. (4159168)

“…The association between a decreased TLR response in periphery and damage of brain in PD must be further investigated.…”

Fig 3 - by Sumei Luo (9570740)

Simulated ground-level light distribution – enhanced uniformity under RSSCA design (a) In crop-growing area under RSSCA systems, and (b) Conventional PV system. by Ngoc-Hai Vu (22290844)

DataSheet1_Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normaliz... by Vanessa B. Candido (14670266)

Decreased mRNA expression of thin and thick filament associated genes in the lack of RYBP during <i>in vitro</i> cardiac differentiation. by Surya Henry (9132175)

Supporting data: Kittiwake conductivity data from Increased summer food supply decreases non-breeding movement in black-legged kittiwakes by Shannon Whelan (8127795)

Supporting data: Kittiwake location data from Increased summer food supply decreases non-breeding movement in black-legged kittiwakes by Shannon Whelan (8127795)