Effect of high-intensity interval training on glycemic control in adults with type 1 diabetes with overweight or obesity: a randomized controlled trial with partial cross-over by Angela S Lee (8996732)

“…<p> </p> <p><b>Research Design and Methods:</b> Thirty inactive adults with type 1 diabetes who had BMI≥25kg/m² and HbA1c≥7.5% were randomized to 12 weeks of either: HIIT exercise intervention consisting of 4x4 minutes HIIT (85-95% HRpeak) performed thrice weekly, or usual care control. …”

UPR gene and protein expression of autoimmune hepatitis (AIH) livers compared to pediatric normal controls (pNormal) and pediatric cholestatic liver disease (pCLD) samples. by Alyssa Kriegermeier (4707226)

“…<p>A) Using qPCR, we determine that: compared to AIH livers (n = 5), pCLD livers (n = 10) had decreased expression of IRE1α, XBP1s, and EDEM1 by 78%, 77%, and 67% while ERdj4 gene expression was similar. …”

Image_2_Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients wi... by Takashi Waki (17836445)

“…</p>Results<p>From 12 May 2016 to 31 March 2020, 5,874 patients (before, n = 4,702; after, n = 1,172) were identified as new metformin users, including 1,145 patients (before, n = 914; after, n = 231) with moderately decreased kidney function. …”

Image_1_Prescription trend and lactic acidosis in patients prescribed metformin before and after the revision of package insert for allowing metformin administration to patients wi... by Takashi Waki (17836445)

“…</p>Results<p>From 12 May 2016 to 31 March 2020, 5,874 patients (before, n = 4,702; after, n = 1,172) were identified as new metformin users, including 1,145 patients (before, n = 914; after, n = 231) with moderately decreased kidney function. …”

Table_3_Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001)... by Rafaella F. Q. Grenfell (12841457)

“…Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. …”

Table_2_Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001)... by Rafaella F. Q. Grenfell (12841457)

“…Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. …”

Table_4_Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001)... by Rafaella F. Q. Grenfell (12841457)

“…Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. …”

Table_1_Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001)... by Rafaella F. Q. Grenfell (12841457)

“…Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. …”

DataSheet_1_Investigating the association between fasting insulin, erythrocytosis and HbA1c through Mendelian randomization and observational analyses.pdf by Anthony Nguyen (312850)

“…</p>Conclusions<p>MR suggests increased FI increases erythrocytosis and might potentially decrease HbA1c by non-glycemic effects. Increased TGI, a surrogate measure of increased FI, associates with lower-than-expected HbA1c in people with preT2D. …”

Table_1_Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study.xlsx by Wei-Wei Chang (1676215)

“…Subgroup analysis showed that, compared with the CC genotype, CG + GG genotype was associated with a decreased risk of T2DM in the subgroup of individuals ≥ 65 years old (OR = 0.75; 95% CI: 0.58–0.98; P_adjusted = 0.032) and BMI < 18.5 (OR = 0.16; 95% CI: 0.03–0.89; P_adjusted = 0.037). …”

Table 2_MiR-99a-5p up-regulates LDLR and functionally enhances LDL-C uptake via suppressing PCSK9 expression in human hepatocytes.docx by Xuemei Chen (14465)

“…Conversely, anti-miR-99a-5p upregulates PCSK9, leading to a reduction in LDLR, attenuation of LDL-C uptake, and a decrease in the intracellular cholesterol levels of human hepatocytes. …”

Table 1_MiR-99a-5p up-regulates LDLR and functionally enhances LDL-C uptake via suppressing PCSK9 expression in human hepatocytes.docx by Xuemei Chen (14465)

“…Conversely, anti-miR-99a-5p upregulates PCSK9, leading to a reduction in LDLR, attenuation of LDL-C uptake, and a decrease in the intracellular cholesterol levels of human hepatocytes. …”

Data_Sheet_5_Knowledge of Symptoms of Acute Myocardial Infarction, Reaction to the Symptoms, and Ability to Perform Cardiopulmonary Resuscitation: Results From a Cross-sectional Su... by Nadja Kartschmit (7148360)

Table 3_MiR-99a-5p up-regulates LDLR and functionally enhances LDL-C uptake via suppressing PCSK9 expression in human hepatocytes.docx by Xuemei Chen (14465)

“…Conversely, anti-miR-99a-5p upregulates PCSK9, leading to a reduction in LDLR, attenuation of LDL-C uptake, and a decrease in the intracellular cholesterol levels of human hepatocytes. …”

Image_3_A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.jpeg by Federica Mangili (10146332)

“…Accordingly, S2152D FLNA expression abolished the expected ability of BIM53097 to increase or decrease, in MMQ and in AtT20 respectively, ERK phosphorylation, an effect that was maintained in S2152A FLNA expressing cells (+1.8 ± 0.65-fold, p < 0.05 in MMQ; -55 ± 13%, p < 0.01 in AtT-20). …”

Image_1_A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.jpeg by Federica Mangili (10146332)

“…Accordingly, S2152D FLNA expression abolished the expected ability of BIM53097 to increase or decrease, in MMQ and in AtT20 respectively, ERK phosphorylation, an effect that was maintained in S2152A FLNA expressing cells (+1.8 ± 0.65-fold, p < 0.05 in MMQ; -55 ± 13%, p < 0.01 in AtT-20). …”

Image_2_A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.jpeg by Federica Mangili (10146332)

“…Accordingly, S2152D FLNA expression abolished the expected ability of BIM53097 to increase or decrease, in MMQ and in AtT20 respectively, ERK phosphorylation, an effect that was maintained in S2152A FLNA expressing cells (+1.8 ± 0.65-fold, p < 0.05 in MMQ; -55 ± 13%, p < 0.01 in AtT-20). …”

Treatment with 1,8-cineole reduced infection and cerebral edema in a model of experimental cerebral malaria. by Edgleyson C. dos Santos (12536575)

R-loops accumulate in p.A382T TDP-43 mutated LCLs. by Marta Giannini (5534324)

DataSheet_3_Integration of single-cell RNA sequencing and bulk RNA sequencing to reveal an immunogenic cell death-related 5-gene panel as a prognostic model for osteosarcoma.pdf by Jiaqi Yang (4380466)

“…</p>Conclusions<p>Overall, ICD represented a protective factor against OS, and our 5-gene risk panel serving as a biomarker could effectively evaluate the prognostic risk in patients with OS.…”