Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Image_5_PLAU Promotes Cell Proliferation and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.TIF by Guangjin Chen (1989892)

“…Notably, the downregulation of PLAU decreased the expression of TNFRSF12A. Moreover, knockdown TNFRSF12A also inhibits cell proliferation and migration. …”

Data_Sheet_1_Loss of function of VdDrs2, a P4-ATPase, impairs the toxin secretion and microsclerotia formation, and decreases the pathogenicity of Verticillium dahliae.docx by Hui Ren (122548)

“…In addition, the defect of VdDrs2 impaired the synthesis of melanin and the formation of microsclerotia, and decreased the sporulation of V. dahliae. Our data indicate a key role of P4 ATPases-associated vesicle transport in toxin secretion of disease fungi and support the importance of mycotoxins in the pathogenicity of V. dahliae.…”

Neutralization potency decreases 6-months post 2^nd vaccine but breadth and potency increase after a 3^rd vaccine dose. by Carl Graham (9415779)

Benefit values for optimal control problem P3 for three distinct harvesting cost weight, <i>ω</i>₃ with fixed <i>ω</i>₁ = 1 and <i>ω</i>₂ = .5. by Maria C. A. Leite (5586701)

Data and R Script: Decreases in chimpanzee respiratory disease signs and enteric viral quantity following implementation of anthroponotic disease prevention protocols at a long-ter... by Jacob Negrey (9541361)

Supplementary Table 1 from A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice by Jo Waaler (1970758)

The induced knockdown of GmCAD receptor protein encoding gene in <i>Galleria mellonella</i> decreased the insect susceptibility to a <i>Photorhabdus akhurstii</i> oral toxin by Tushar K. Dutta (9406648)

Supplementary Material for: A Polymorphism in the Gene Encoding the Insulin Receptor Binding Protein ENPP-1 Is Associated with Decreased Glomerular Filtration Rate in an Under-Inve... by Cave E.M. (9719192)

Regression of soil respiration (Rs) and soil temperature (T) fitted models of (a) control, (b) low burn severity, and (c) high burn severity in the non-growing season. by Tongxin Hu (4217563)

Data_Sheet_1_5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model.docx by Xujiao Zhou (6661499)

“…In addition, the high expression of GS and EAAT2 induced by glaucoma was downregulated by the 5-HT1A receptor agonist 8-OH-DPAT and the 5-HT1A receptor antagonist WAY-100635, respectively. …”

Chromatograms proved the selectivity of the proposed method. Red line: tissue spiked at the LOQ level; green line: blank tissue. Panel A: SIM and SIMA; panel B: LOV and LOVA. by Ewa Paszkowska (21246702)

Depletion of DOM-A, but not DOM-B affects s-LN_vs maintenance and PDF accumulation. by Zhenxing Liu (399809)

“…Cell number of sLN_vs (marked as square brackets), PDF, PER and TIM levels in sLN_vs were decreased in <i>dom</i> and <i>domA</i> downregulation flies brains (Top right and bottom left panels), while only affected PER and TIM levels in <i>domB</i> downregulation flies (Bottom right panel). …”

Large amounts of ingested phenylpyruvate are required to decrease the survival of adult <i>A. gambiae</i> mosquitoes. by Silke Fuchs (506300)

Image_5_The Effects of a Single Oral Dose of Pyridoxine on Alpha-Aminoadipic Semialdehyde, Piperideine-6-Carboxylate, Pipecolic Acid, and Alpha-Aminoadipic Acid Levels in Pyridoxin... by Junjuan Wang (2833112)

“…Whereas, the metabolites concentrations might increase or decrease among different patients, or in different samples of the same patient, without a regular tendency. …”

Image_1_Evaluating Uncertainties in Reconstructing the Pre-eutrophic State of the North Sea.TIF by Christoph Stegert (10427723)

“…For the reconstruction of the historical state, we use two coupled physical-biogeochemical model systems: ECOHAM on a 20-km grid for the European shelf and GPM on a high-resolution (1.5–4.5 km) grid for the Southern North Sea. …”