Table_1_Characterization of CRISPR-Cas Systems in Clinical Klebsiella pneumoniae Isolates Uncovers Its Potential Association With Antibiotic Susceptibility.doc by Hsin-Yu Li (5516420)

“…Among clinical isolates, more type I-E CRISPR-Cas systems were found in UTI isolates (BSI, 5.7%; UTI, 11.2%), and subtype I-E^∗ CRISPR-Cas systems were dominant in BSI isolates (BSI, 28.7%; UTI, 15.7%) (p = 0.042). …”

Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat by Jie-Ning Zhu (463126)

“…Enforced expression of miR-29b significantly suppressed Col1a1, Col3a1, and α-SMA expression. Taken together, we found that smad3 inactivation and miR-29b upregulation contributed to the cardioprotective activity of carvedilol against AMI-induced myocardial fibrosis. …”

DataSheet1_Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver.PDF by MengLin Chen (11747123)

“…<p>CYP2B10 is responsible for metabolism and detoxification of many clinical drugs. Here, we aimed to investigate a potential role of Period 2 (PER2) in regulating expression of hepatic CYP2B10. …”

Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity by Alessandro Marsili (217139)

“…</p> <h3>Methodology/Principal Findings</h3><p>After 6-weeks of HFD feeding D2KO mice gained 5.6% more body weight and had 28% more adipose tissue. …”

Image2_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.JPEG by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

Enriched taxa were found among the gut microbiota of centenarians in East China by Na Wang (193263)

“…<i>5139BFAA</i> and <i>Clostridium sp</i>.<i>AT5</i> decreased in the 90–99 year age group. The age differences in gut microbiota were similar across the strata of smoking, alcohol consumption status and food preference.…”

Data Sheet 7_Assessing the disease burden of lower respiratory infections attributable to particulate matter pollution: trends from 1990 to 2021 and projections for 2022-2050.pdf by Erman Wu (19021269)

“…Regional heterogeneity was marked, with Central Sub-Saharan Africa bearing the highest HAP burden and minimal APMP improvement (EAPC: -0.24%). Children under 5 years of age group still accounted for the most PMP-related deaths, with the number decreasing from 851,458 (95% UI: 211,026 to 1,363,810) in 1990 to 201,078 (95% UI:61,817 to 337,232). …”

Table1_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.xlsx by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

Data_Sheet_1_Low-dose-rate induces more severe cognitive impairment than high-dose-rate in rats exposed to chronic low-dose γ-radiation.zip by Tianbao Ma (3366986)

“…</p>Methods<p>The rats were exposed to γ-irradiation at a LDR of 6 mGy/h and a HDR of 20 mGy/h for 30 days (5 h/day). Functional imaging was performed to assess the brain inflammation and blood–brain barrier (BBB) destruction of rats. …”

Table_4_Current status, trends, and predictions in the burden of silicosis in 204 countries and territories from 1990 to 2019.DOCX by Xinglin Yi (16447332)

“…The age-period-cohort analysis forecasted a decreasing trend of the burden of silicosis from 2019 to 2044.…”

Image_4_Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes.TIF by Leonardo Albarracin (5780780)

“…<p>Previously, we evaluated the effect of the immunobiotic strain Lactobacillus rhamnosus CRL1505 on the transcriptomic response of porcine intestinal epithelial (PIE) cells triggered by the challenge with the Toll-like receptor 3 (TLR-3) agonist poly(I:C) and successfully identified a group of genes that can be used as prospective biomarkers for the screening of new antiviral immunobiotics. …”

Data Sheet 3_Assessing the disease burden of lower respiratory infections attributable to particulate matter pollution: trends from 1990 to 2021 and projections for 2022-2050.pdf by Erman Wu (19021269)

“…Regional heterogeneity was marked, with Central Sub-Saharan Africa bearing the highest HAP burden and minimal APMP improvement (EAPC: -0.24%). Children under 5 years of age group still accounted for the most PMP-related deaths, with the number decreasing from 851,458 (95% UI: 211,026 to 1,363,810) in 1990 to 201,078 (95% UI:61,817 to 337,232). …”

Image_1_Perioperative, functional, and oncological outcomes of robotic vs. laparoscopic partial nephrectomy for complex renal tumors (RENAL score ≥7): an evidence-based analysis.ti... by Li Wang (15202)

“…Review Manager 5.4 performed a pooled analysis of the data for random effects. …”

Image_3_Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation.tif by Margaret K. Seeley-Fallen (12415624)

“…NMII recruitment depended on phosphatidylinositol 5-phosphatase (SHIP1), an inhibitory signaling molecule. …”

Data_Sheet_1_Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy.xlsx by William E. Funk (2405977)

“…These children were selected to maximize the range of residential air pollution exposure during the entire pregnancy to PM_2.5, PM₁₀, NO₂, O₃, based on monthly estimates interpolated from regulatory monitoring sites. …”

Image1_Optogenetic Manipulations of Amygdala Neurons Modulate Spinal Nociceptive Processing and Behavior Under Normal Conditions and in an Arthritis Pain Model.tiff by Mariacristina Mazzitelli (10869657)

“…Extracellular single unit recordings were made from spinal dorsal horn wide dynamic range (WDR) neurons, which respond more strongly to noxious than innocuous mechanical stimuli, in normal and arthritic adult rats (5–6 h postinduction of a kaolin/carrageenan–monoarthritis in the left knee). …”

Table 1_Prognostic significance of early alpha fetoprotein and des-gamma carboxy prothrombin responses in unresectable hepatocellular carcinoma patients undergoing triple combinati... by Teng Zhang (457128)

“…AFP and DCP responses were defined as decreases from baseline of over 50% and 70%, respectively, according to ROC curve analysis. …”

Image_2_Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66.PNG by Lanxin Luo (5868185)

“…The efficacy of a new bumetanide (BMT)-derivative NKCC1 inhibitor STS66 [3-(butylamino)-2-phenoxy-5-[(2, 2, 2-trifluoroethylamino) methyl] benzenesulfonamide] in blocking NKCC1 activity was compared with well-established NKCC1 inhibitor BMT.…”

Image_2_Microvascular Dysfunction in Skeletal Muscle Precedes Myocardial Vascular Changes in Diabetic Cardiomyopathy: Sex-Dependent Differences.TIFF by Sadi Loai (12559255)

“…Exercise tolerance declined progressively and early in males (4 months), later in females (8 months); FMD showed lower baseline femoral arterial flow but unchanged reactivity in both sexes (5 months); and photoacoustic imaging showed lower tissue oxygen saturation in the legs of diabetic males (4 months) and diabetic females (10 months). …”

Table_1_Constraint-Based Modeling Highlights Cell Energy, Redox Status and α-Ketoglutarate Availability as Metabolic Drivers for Anthocyanin Accumulation in Grape Cells Under Nitro... by Eric Soubeyrand (5230856)

“…However, this hypothesis has never been tested directly. To this end, we used the grapevine Vitis vinifera L. cultivar Gamay Teinturier (syn. …”