Image_1_Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice.JPEG by Xiaofan Yang (767342)

“…Cerebellar dysfunction has been implicated in autism spectrum disorder. We investigated conditional Scn8a knockout mice under C57BL/6J strain background that specifically lack Scn8a expression in cerebellar Purkinje cells (Scn8a^flox/flox, L7Cre⁺ mice). …”

Table 1_Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024.docx by Miao Liu (148274)

“…Background<p>Pertussis is a highly contagious disease caused by Bordetella pertussis (BP) and remains endemic worldwide, with cyclic epidemics occurring every 2–5 years. Non-pharmaceutical interventions (NPIs) implemented during the COVID-19 have altered the epidemiology of respiratory infectious diseases. …”

Data_Sheet_1_Quantitative acetylated proteomics on left atrial appendage tissues revealed atrial energy metabolism and contraction status in patients with valvular heart disease wi... by Tao Tu (456663)

“…Changes in the quantitative acetylated proteome between the AF and sinus rhythm (SR) groups were studied by dimethyl labeling, acetylation affinity enrichment, and high-performance liquid chromatography-tandem mass spectrometry analysis.</p>Results<p>We identified a total of 5,007 acetylated sites on 1,330 acetylated proteins, among which 352 acetylated sites on 193 acetylated proteins were differentially expressed between the AF and SR groups by setting a quantification ratio of 1.3 for threshold value and P < 0.05 for significant statistical difference. …”

A highly expressed intestinal cysteine protease of <i>Ancylostoma ceylanicum</i> protects vaccinated hamsters from hookworm infection by Jason B. Noon (3255876)

“…</p><p>Methodology/Principal findings</p><p>We investigated the vaccine efficacy in outbred Syrian hamsters of three <i>A</i>. …”

Supplementary Material for: Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage by Kolkhof P. (7545230)

“…Treatment with finerenone and the low-dose combination significantly decreased systolic blood pressure after 5 weeks. There was a dose-dependent protection from cardiac and kidney fibrosis and vasculopathy with both agents, while low-dose combination therapy was more efficient than the respective monotherapy dosages on most cardiorenal histology parameters. …”

Image6_Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.jpeg by Taiki Sato (394623)

“…Notably, Il9ra-deficient Tfh cells in the spleen exhibited decreased expression of their signature molecules such as B-cell lymphoma 6, C-X-C chemokine receptor 5, IL-4, and IL-21 compared to control mice. …”

Image_1_The prevalence of diabetes and thyroid related autoantibodies in Sri Lankan children with type 1 diabetes and their unaffected siblings – The utility of a new screening ass... by Navoda Atapattu (14570081)

“…</p>Results<p>The median age (IQR) of 235 T1D children and 252 unaffected siblings was 11 (8.4, 13.2) and 9 (5.4, 14.9) years respectively, and the duration of T1D was 23 (7, 54) months. (1) T1D children (a) 79.1% were 3-Screen positive; (b) all 3-Screen positives were individual antibody positive (GADA in 74%; IA-2A 31.1%; ZnT8A 38.7%); (c) and were younger (p=0.01 vs 3-Screen negatives); (d) multiple autoantibodies were present in 45.1%; (e) IA-2A (p=0.002) and ZnT8A (p=0.006) prevalence decreased with T1D duration. …”

Data_Sheet_1_The Effect of Nutrition Intervention With Oral Nutritional Supplements on Ovarian Cancer Patients Undergoing Chemotherapy.XLSX by Nan Qin (610407)

“…A progressive trend toward amelioration in PG-SGA scores over time was found within the ONS group, with scores decreasing from 9.27 ± 1.68 at baseline (T0) to 5.87 ± 2.06 after the intervention (T3). …”

Table1_Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.xlsx by Taiki Sato (394623)

“…Notably, Il9ra-deficient Tfh cells in the spleen exhibited decreased expression of their signature molecules such as B-cell lymphoma 6, C-X-C chemokine receptor 5, IL-4, and IL-21 compared to control mice. …”

Identification of SNP loci and candidate genes related to four important fatty acid composition in <i>Brassica napus</i> using genome wide association study by Qianglong Zhu (3614309)

“…Furthermore, 108 highly favorable alleles for increasing oleic acid and linoleic acid content, also for decreasing erucic acid content simultaneously were observed. …”

Table 4_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…However, the combined treatment was associated with an increased incidence of total/grade 3–5 treatment emergent AEs (TEAEs), and immune-related AEs (irAEs), although the overall safety profile remained manageable. …”

Image3_Identification of novel TMEM231 gene splice variants and pathological findings in a fetus with Meckel Syndrome.JPEG by Qian Zhang (49333)

“…The two variants were predicted to be pathogenic by in silico tools and were classified as pathogenic/likely pathogenic variants according to the American College of Medical Genetics and Genomics guideline. cDNA TA cloning analysis showed that both splice site variants caused a deletion of exon 5. RT-PCR revealed that the expression of TMEM231 was significantly decreased and immunofluorescence showed that the primary cilium was almost absent in the proband’s kidney tissue.…”

High SMAD7 and p-SMAD2,3 expression is associated with environmental enteropathy in children by Sana Syed (4591699)

“…Environmental enteropathy (EE) is an acquired inflammatory disease of the small intestine (SI), which is associated with linear growth disruption, cognitive deficits, and reduced oral vaccine responsiveness in children <5 y in resource-poor countries. We aimed to characterize EE inflammatory pathways by determining SMAD7 and p-SMAD2,3 levels (using Western blotting) in EE duodenal biopsies (N = 19 children, 7 from Pakistan, 12 from Zambia) and comparing these with healthy controls (Ctl) and celiac disease (CD) patients from Italy. …”

TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium by Hyun-Kyoung Kim (439501)

“…TMBIM6 (transmembrane BAX inhibitor motif containing 6) is a Ca²⁺ channel-like protein known to regulate ER stress response and apoptosis. In this study, we examined the as yet unknown role of TMBIM6 in regulating lysosomal Ca²⁺ levels. …”

Table_2_Single-Dose Versus Multiple-Dose GnRH Agonist for Luteal-Phase Support in Women Undergoing IVF/ICSI Cycles: A Network Meta-Analysis of Randomized Controlled Trials.docx by Yang Liu (4829)

“…This network meta-analysis was therefore performed to determine the comparative efficacy and safety of multiple-dose versus single-dose GnRH agonist protocol for LPS in patients undergoing IVF/ICSI cycles.</p>Methods<p>We searched relevant studies in PubMed, Embase and the Cochrane Registry of Controlled Trials (CENTRAL) from their inception util to September 2021. …”

Table_1_Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy.docx by William E. Funk (2405977)

“…These children were selected to maximize the range of residential air pollution exposure during the entire pregnancy to PM_2.5, PM₁₀, NO₂, O₃, based on monthly estimates interpolated from regulatory monitoring sites. …”

Data_Sheet_2_Qing-Kai-Ling oral liquid alleviated pneumonia via regulation of intestinal flora and metabolites in rats.PDF by Hongying Chen (53706)

“…The study aimed to investigate the potential mechanism by which QKL alleviates pneumonia from the perspective of ‘microbiota-metabolites-host’ interaction.</p>Methods<p>We evaluated the therapeutic effects of QKL on lipopolysaccharide (LPS)-induced pneumonia rats. …”

Phenotype and Functions of Natural Killer Cells in Critically-Ill Septic Patients by Jean-Marie Forel (64985)

“…</p> <h3>Objective</h3><p>We studied the phenotype and functions of circulating NK cells in critically-ill septic patients.…”

Image9_Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.jpeg by Taiki Sato (394623)

“…Notably, Il9ra-deficient Tfh cells in the spleen exhibited decreased expression of their signature molecules such as B-cell lymphoma 6, C-X-C chemokine receptor 5, IL-4, and IL-21 compared to control mice. …”

Image_8_Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes.TIF by Leonardo Albarracin (5780780)

“…<p>Previously, we evaluated the effect of the immunobiotic strain Lactobacillus rhamnosus CRL1505 on the transcriptomic response of porcine intestinal epithelial (PIE) cells triggered by the challenge with the Toll-like receptor 3 (TLR-3) agonist poly(I:C) and successfully identified a group of genes that can be used as prospective biomarkers for the screening of new antiviral immunobiotics. …”