Image 6_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…However, the combined treatment was associated with an increased incidence of total/grade 3–5 treatment emergent AEs (TEAEs), and immune-related AEs (irAEs), although the overall safety profile remained manageable. …”

Image3_Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.jpeg by Taiki Sato (394623)

“…Notably, Il9ra-deficient Tfh cells in the spleen exhibited decreased expression of their signature molecules such as B-cell lymphoma 6, C-X-C chemokine receptor 5, IL-4, and IL-21 compared to control mice. …”

B-Cell Dysregulation in Crohn's Disease Is Partially Restored with Infliximab Therapy by Wilhelmina M. C. Timmermans (3145413)

“…</p><p>Objective</p><p>To elucidate the involvement of B cells in Crohn’s disease, we here performed an ‘in depth’ analysis of intestinal and blood B-cells in this chronic inflammatory disease.…”

Image 3_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co... by Yun Xu (139234)

“…However, the combined treatment was associated with an increased incidence of total/grade 3–5 treatment emergent AEs (TEAEs), and immune-related AEs (irAEs), although the overall safety profile remained manageable. …”

Table_1_Low GNG12 Expression Predicts Adverse Outcomes: A Potential Therapeutic Target for Osteosarcoma.docx by Jinghong Yuan (11057892)

“…This study hypothesized that GNG12 may be a potential biomarker and therapeutic target. We aimed to identify an association between GNG12 and osteosarcoma based on the Gene Expression Omnibus and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) databases.…”

DataSheet_1_Circulating extracellular vesicles are associated with the clinical outcomes of sepsis.pdf by Pengfei Li (290581)

“…MiR-126-3p levels in EC EVs were significantly decreased in ARDS patients compared with healthy controls (p<0.05). …”

Burrows of the Semi-Terrestrial Crab <i>Ucides cordatus</i> Enhance CO₂ Release in a North Brazilian Mangrove Forest by Nathalie Pülmanns (644407)

“…This increase in sediment-air contact area may enhance carbon degradation processes. We hypothesized that 1) the sediment CO₂ efflux rate is greater with burrows than without and 2) the reduction potential in radial profiles in the sediment surrounding the burrows decreases gradually, until approximating non-bioturbated conditions. …”

Dietary Methanol Regulates Human Gene Activity by Anastasia V. Shindyapina (168682)

Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 by Razieh, Hassannejad

“…FindingsIn contrast with the decreasing trend of HF burden globally, EMR showed an increasing trend. …”
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Silicon Enhances Morpho–Physio–Biochemical Responses in Arsenic Stressed Spinach (Spinacia oleracea L.) by Minimizing Its Uptake by Saleem, Muhammad Hamzah

“…Fifteen days old seedlings of S. oleracea were subjected to the different concentrations of As, i.e., 0 (no As), 50, and 100 µM in the soil which were also supplied with the different exogenous levels of Si, i.e., 0 (no Si), 1.5, and 3 mM. Results from the present study revealed that the As toxicity induced a substantial decreased in shoot length, root length, number of leaves, leaf area, shoot fresh weight, root fresh weight, shoot dry weight, root dry weight, chlorophyll-a, chlorophyll-b, total chlorophyll, carotenoid content, net photosynthesis, stomatal conductance, transpiration rate, soluble sugar, reducing sugar, non-reducing sugar contents, calcium (Ca2+), magnesium (Mg2+), iron (Fe2+), and phosphorus (P) contents in the roots and shoots of the plants. …”
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Table 1_Global, regional, and national burden of myocarditis in children aged 0–14 years, 1990–2021: analysis for the global burden of disease study 2021.docx by Yi-Dong Zhang (20457863)

“…Over 30 years, the global incidence rate decreased from 8.27 (95% UI, 5.35–12.34) to 7.73 (95% UI, 4.99–11.55) per 100,000 population. …”

Data_Sheet_2_Efficacy of the Chinese herbal medicine Jintiange capsules in the postoperative treatment of osteoporotic vertebral compression fractures: a systematic review and meta... by Yongsheng Fu (2045095)

“…</p>Results<p>We enrolled randomized controlled trials (RCTs) focusing on 1,642 patients in the meta-analysis. …”

Data Sheet 1_Real-world data of cadonilimab in recurrent or metastatic cervical cancer in China: a multicentric study.docx by Jian Chen (15340)

“…The most common grade 3 or worse adverse event was anemia (28 [20.1%]), decreased white blood cell count (24 [17.2%]), and decreased neutrophil count (20 [14.4%]). …”

Table_1_Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-li... by Yan Zhou (6523)

“…Patients with vitamin D deficiency (Lo) had varying degrees of elevation of the pro-inflammatory cytokines IL-5, IL-6, and IL-17A, decreased expression of the anti-inflammatory cytokine IL-10, and altered forced expiratory volume in the first second as a percentage of predicted value (FEV₁%pred) in both asthmatic endotypes. …”

DNA Methylation in <i>Cosmc</i> Promoter Region and Aberrantly Glycosylated IgA1 Associated with Pediatric IgA Nephropathy by Qiang Sun (225630)

“…After treatment with IL-4, the levels of <i>Cosmc</i> DNA methylation and aberrantly glycosylated IgA1 in IgAN lymphocytes were remarkably higher than the other two groups (<i>P</i><0.0001) with more markedly decreased Cosmc mRNA content (<i>P</i><0.0001). After treatment with AZA, the levels in IgAN lymphocytes were decreased, but was still remarkably higher than the other two groups (<i>P</i><0.0001), while Cosmc mRNA content in IgAN lymphocytes were more markedly increased than the other two groups (<i>P</i><0.0001). …”

DataSheet_1_Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during earl... by Yan Zhou (6523)

“…Patients with vitamin D deficiency (Lo) had varying degrees of elevation of the pro-inflammatory cytokines IL-5, IL-6, and IL-17A, decreased expression of the anti-inflammatory cytokine IL-10, and altered forced expiratory volume in the first second as a percentage of predicted value (FEV₁%pred) in both asthmatic endotypes. …”

Table1_Isoimperatorin therapeutic effect against aluminum induced neurotoxicity in albino mice.DOCX by Peramaiyan Rajendran (109720)

“…Several plant-derived natural biomolecules have been recently used to reduce the toxic effects of Al through decreasing the oxidative stress and the associated diseases. …”

Table_1_Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.pdf by Chengfei Wu (5106272)

“…The proportion of CD25⁺Foxp3⁺CD4⁺ regulatory T cell (Foxp3⁺ Treg) in the pancreas, pancreatic and mesenteric lymph nodes was analyzed by flow cytometry. We found that LMP supplementation ameliorated T1D development in non-obese diabetic (NOD) mice, as evidenced by decreasing diabetes incidence and fasting glucose levels in LMP fed NOD mice. …”

HIV specific CD4+ and CD8+ T cell functionality is reduced in HIV infected individuals co-infected with latent Mycobacterium tuberculosis infection (LTBI) and active Tuberculosis (... by Shivan Chetty (159334)

“…<b>(E)</b> HIV-specific four function CD4+ T cells were not present in subjects co-infected with LTBI <b>(F)</b> Further decreases in HIV-specific CD4+ T cell polyfunctionality were observed in HIV positive subjects co-infected with TB, being replaced by a largely mono-functional profile with a decreased amount of triple cytokine cells (5% as compared to 13% in HIV/LTBI and 15% in HIV mono-infection). …”

Data_Sheet_1_Efficacy of the Chinese herbal medicine Jintiange capsules in the postoperative treatment of osteoporotic vertebral compression fractures: a systematic review and meta... by Yongsheng Fu (2045095)

“…</p>Results<p>We enrolled randomized controlled trials (RCTs) focusing on 1,642 patients in the meta-analysis. …”