Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

B-THP-Ts decrease cellular ATP levels. by Lindsay B. Tulloch (1266861)

hESCs-CM inhibited cell cycle progression of cancer cells and initiated a pro-apoptotic program. by Shufeng Zhou (398572)

Decrease in circulating iNKT cell activation during regadenoson (RA) infusion into patients with COVID-19. by Joseph Rabin (7399436)

Subjects:

LRP1 interacts with GluA1 and regulates its turnover in neurons. by Ming Gan (673850)

In the absence of insulin, dexamethasone (Dex) decreases lipogenesis as measured by 1-[¹⁴C]-acetate incorporation into lipid in differentiated Chub-S7 cells in a dose de... by Laura L. Gathercole (341979)

ArxE mice have almost complete loss of α-cell fate by P14 with a concomitant decrease in total endocrine mass, but no change in β- and δ-cell mass. by Crystal L. Wilcox (421799)

Open data. by Larissa Brazolotto Ferreira (17671168)

“…For the group of EBF + who practiced complementary breastfeeding after 6 months, densitometric results indicated a tendency to incorporation of bone mass, with a mean percentage increase in BMD of 5.0 ± 3.9% for lumbar spine, and 1.6 ± 3.4% for total proximal femur.…”

hCDC-derived exosomes significantly decrease cardiomyocyte programed cell death and cause a trend toward increased proliferation of cardiomyocytes <i>in vitro</i> at one week in cu... by Jennifer K. Lang (344441)

TCR-induced proximal signaling is decreased in <i>Gimap5</i> deficient T cells. by Xi-Lin Chen (803969)

Pairwise comparisons of hormonal results for DMPA-IM vs NET-EN expressed as mean percentage differences (95% CI) (mITT analysis). by Chanel Avenant (409756)

Aβ and 22C11 agonist decreased cholesterol uptake whereas the sAPP-derived peptide and SM-ϕ stimulated increased cholesterol uptake by Caco-2 cells. by Kendra L. Puig (334788)

Inverse relationship between poison exon usage and expression of multiple sodium channels during mouse brain development. by Yuliya Voskobiynyk (9954619)

“…<p>(A) <i>Scn1a</i> transcripts including exon 20N are highly expressed in the developing mouse brain and decrease dramatically after birth (aqua bars), with a corresponding developmental increase in <i>Scn1a</i> expression (blue bars). …”

PI+ CD3+ T cells decrease at day 14 after IR while PI+ CD3- cells decrease at all time points. by Jordan A. Gunning (18143970)

Decreased peritumoral myofibroblasts in the MC38 S.C. tumors of <i>S100a4-Cre; Ext1</i>^<i>f/f</i> mice. by Ayumi Niwa (6256790)

Heat-treated spores show a decrease in the overall number of spores that are able to germinate and grow out within 5 hours. by Rachna Pandey (394151)

Blocking of MC1R, MC2R or MC5R causes a decrease in the enucleation ratio of erythrocytes. by Eriko Simamura (720229)

“…Cell number is significantly decreased after treatment with anti-MC2R nAb for 5 days; however, treatment with anti-MC1R nAb or anti-MC5R nAb does not have a significant effect (n = 3, ANOVA). …”

At E9.5 Actb^−/− neural crest cells show a significant decrease of cadherin-11 expression. by Davina Tondeleir (426905)

“…<p>(A) Quantification of N-cadherin intensities in Actb^+/+ and Actb^−/− migratory cells adjacent to the neural tube at E8.5 and E9.5 (left graph, Y-axis: relative intensities) and colocalization of N-cadherin with p75 in migratory cells at E8.5 and E9.5 (right graph, Y-axis: colocalization index on a scale from 0 to 1). …”

Trend of temperature decrease in thermogradient freezer during the night from 7:00 P.M. to 5:00 A.M. by Alireza Hasanfard (13919335)

“…<p>Trend of temperature decrease in thermogradient freezer during the night from 7:00 P.M. to 5:00 A.M.…”