Image_3_Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2.jpeg by Mariette Barbier (526468)

“…In addition, the cost of creating these therapeutic treatments is high, making their implementation in low- to middle-income countries devastated by the pandemic very difficult. Here, we explored the use of polyclonal EpF(ab’)₂ antibodies generated through the immunization of horses with SARS-CoV-2 WA-1 RBD conjugated to HBsAg nanoparticles as a low-cost therapeutic treatment for severe cases of disease. …”

Image_1_Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2.jpeg by Mariette Barbier (526468)

“…In addition, the cost of creating these therapeutic treatments is high, making their implementation in low- to middle-income countries devastated by the pandemic very difficult. Here, we explored the use of polyclonal EpF(ab’)₂ antibodies generated through the immunization of horses with SARS-CoV-2 WA-1 RBD conjugated to HBsAg nanoparticles as a low-cost therapeutic treatment for severe cases of disease. …”

Image_3_Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2.jpeg by Mariette Barbier (526468)

“…In addition, the cost of creating these therapeutic treatments is high, making their implementation in low- to middle-income countries devastated by the pandemic very difficult. Here, we explored the use of polyclonal EpF(ab’)₂ antibodies generated through the immunization of horses with SARS-CoV-2 WA-1 RBD conjugated to HBsAg nanoparticles as a low-cost therapeutic treatment for severe cases of disease. …”

Image_2_Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2.jpeg by Mariette Barbier (526468)

“…In addition, the cost of creating these therapeutic treatments is high, making their implementation in low- to middle-income countries devastated by the pandemic very difficult. Here, we explored the use of polyclonal EpF(ab’)₂ antibodies generated through the immunization of horses with SARS-CoV-2 WA-1 RBD conjugated to HBsAg nanoparticles as a low-cost therapeutic treatment for severe cases of disease. …”

Femtosecond laser-ablative aqueous synthesis of multi-drug antiviral nanoparticles by Rebecca R. Schmitt (20872565)

“…In this work, we introduce a multi-drug nanoparticle fabricated using femtosecond laser ablation for the treatment of influenza, SARS-CoV-2, and their co-infections.…”

The effect of NaOH pretreatment on coal structure and biomethane production by Hongguang Guo (6934409)

EP1 mediates pelvic pain. by Wenbin Yang (661259)

“…In contrast, mice treated with the EP1 antagonist ONO-8711 exhibited significantly decreased allodynia 1 h after treatment relative to baseline (Baseline_ONO) (n = 5 mice, **P < 0.01, unpaired <i>t</i> test; see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0235384#pone.0235384.s001" target="_blank">S1 File</a>).…”

Table_5_Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells.xlsx by Kari Guderud (8448846)

Immune cell subsets and cytokine levels in peripheral blood between healthy donors and triple-negative breast cancer (TNBC) patients and in patients before and after the first phas... by Nicole Chicken (19806183)

A mt-tRNA^Ser(UCN) point mutation, m.7480A>G, impairs i⁶A37 modification. by John W. Yarham (573109)

“…<b>B</b>) The i⁶A modification of position 37 is decreased (stronger binding of the mt-tRNA^Ser(UCN) double ACL probe) by ∼86% in patient skeletal muscle relative to control muscle. …”

Combination of compound C (CC) and chloroquine (CQ) treatment synergistically inhibits the coronavirus infection. by Minsu Jang (2817730)

The ability of the bacterium Aminobacter MSH1 to establish in sand microcosms and degrade the pesticide-residue BAM when inoculated in concentrations of 10⁵ cells L<sup>... by Flemming Ekelund (304569)

“…We fitted data to a simple bell-shaped Gaussian curve; y = a*exp(0.5*((x- d_opt)/b)²), to test the underlying hypothesis that BAM-degradation would be most efficient at intermediate diversity-levels. …”

DataSheet_1_Extracellular vesicle-associated microRNA-30b-5p activates macrophages through the SIRT1/ NF-κB pathway in cell senescence.pdf by Yu Xiao (150812)

“…Significantly more EVs were found in the supernatant of SEN than of control (CON) cell cultures, and SEN EVs were enriched in miR-30b-5p, which directly target sirtuin1 (SIRT1). In vitro, we found that SEN EV treatment resulted in increased cellular levels of interleukin-1β (IL-1β) and IL-6 and decreased levels of SIRT1. …”

Few-Shot Symbol Detection in Engineering Drawings by Laura Jamieson (19759235)

Compound C treatment inhibits coronavirus replication. by Minsu Jang (2817730)

Nuclear Acss2 regulates <i>in vitro</i> tumor cell properties. by Rui Chen (95310)

“…Comparison of samples within a given condition on the day of interest was performed by two-way (cell proliferation) or one-way (colony formation, cell migration, cell invasion) ANOVA followed by Dunnett’s multiple comparisons test using control shRNA knockdown/control rescue as reference with decreased samples noted (*, P<0.05). …”

Representative Boolean gating strategy for the analysis of the cytokine co-expression profiles of CD4+ T cells after stimulation with T. cruzi antigens. by María Ailén Natale (6843422)

Silencing of <i>MYCN</i> selectively alters genomic DNA binding of its cofactors. by Zhihui Liu (95891)

“…(<b>B</b>) Metagene plots show that the knockdown of <i>MYCN</i> results in a decrease of average MYCN and WDR5 ChIP-seq signal at the MYCN peak center of the MYCN and WDR5 overlapped binding sites. …”

Inhibitors targeting canonical and non-canonical TGFβ signaling show that SNC first targets TAK/p38 signaling and then indirectly Smad signaling. by Alison M. Heffer (7392503)

“…B) After 48 hours, cells treated with TGFβ in the presence of both SB-431542 and SNC showed decreased Smad signaling. C) TAK signaling was affected both after 1 hour (C) and 48 hours (D) in cells treated with either the TAK inhibitor (5Z)-7-oxozeaenol or SNC upon TGFβ stimulation. …”

Table_5_Global trends of interstitial lung diseases from 1990 to 2019: an age–period–cohort study based on the Global Burden of Disease study 2019, and projections until 2030.DOCX... by Qi Zeng (221318)

“…Period effect indicated that the RR of prevalence increased over time, whereas the RR of mortality and DALYs decreased in men but increased in women. The cohort effect exhibited that the more recent birth cohort had a higher RR than the previous cohort in prevalence. …”