Evidence of decanalization. by Eric J. Hayden (307357)

“…UV absorbance was measured in 10 mM sodium cacodylate buffer (pH 7.5). The plot shows an example of the best-fit curve to data plotted as a derivative of the UV-absorbance (dA/dT) as a function of temperature (°C) for the <i>Azo*</i> (red) and wild-type (blue) ribozymes. …”

Profile of miRNA expression in asthmatic patients treated before and following treatment with budesonide. by Andrew E. Williams (262992)

“…Red indicates an increase in expression and green a decrease in expression relative to the mean expression of 227 miRNAs. …”

Gradual increase in the extent of γ-secretase saturation with its substrate leads to gradual changes from the biphasic to the standard dose-response curves. by Željko M. Svedružić (105215)

“…Further increase in the substrate (i.e. cDNAwtC99 >250 ng/mL) leads to decrease in Aβ 1–40 secretion (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050759#pone-0050759-t002" target="_blank">Table 2B</a>), which indicates that the substrate can also bind to the inhibition site (i.e. antagonism between complex <b><u>5</u></b> and complex <b><u>6</u></b>).…”

Supplemental Figure 1 by Chelsea Hutch (10156097)

Activation of the UPR can override the inhibition of NF-κB by IKK inhibitors in cancer cells with elevated IKK activity. by Arvin B. Tam (124164)

“…A reduction in P-IκBα and increase in total IκBα were seen corresponding to a decrease in IKK activity. …”

Riccardin D inhibited angiogenesis in intestinal polyps. by Hui-Ping Liu (290636)

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Figure bi demonstrates the increase in Rh123 fluorescence at 1 minute, 6 minutes and 12 minutes that reflects mitochondrial membrane depolarisation in PINK1 ko cells. c, d: Single cell traces of PINK1 ko neurons demonstrating that dopamine induced decrease in ΔΨ_m occurs independently of any change in [Ca²⁺]_c in some cells (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1c</a>), whereas in other cells dopamine induced decrease in ΔΨ_m co-incides with a rise in [Ca²⁺]_c (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1d</a>). e: Incubation with D1/D5 receptor antagonist SCH23390 (20 µM) did not alter the dopamine induced calcium signal or mitochondrial depolarisation in PINK1 ko neurons. f: Dopamine induced mitochondrial depolarisation was prevented by application of the PTP inhibitor 1 µM cyclosporine A.…”

Elimination testing with adapted scoring reduces guessing and anxiety in multiple-choice assessments, but does not increase grade average in comparison with negative marking by Jef Vanderoost (5108072)

“…The comparison is structured around seven hypotheses: in comparison with negative marking, elimination testing with adapted scoring leads to (1) a similar average score (no grade inflation); (2) students expressing their partial knowledge; (3) a decrease in the number of blank answers; (4) no gender bias in the number of blank answers; (5) a reduction in guessing; (6) a decrease in self-reported test anxiety; and finally (7) students preferring elimination testing with adapted scoring over negative marking.…”

Calcareous nannofossil biostratigraphy of the Late Cretaceous‒early Paleocene interval in the Zagros basin (southeastern Tethys), Iran by Azam Mahanipour (10126937)

“…This study concentrates on two sections (the Gurpi and Kabir-Kuh sections) in the west and southwest of Iran in the Zagros Basin, which span biozones CC25c/UC20bTP to NP6/NTp10B in the Kabir-Kuh and CC25b/UC20aTP to NP5/NTp9 in the Gurpi section. Late Maastrichtian nannofossil abundance and diversity in the studied intervals is high with a sharp decrease slightly above the K/Pg boundary. …”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-0 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”

Table_1_Trends in the Utilization of Teleneurology and Other Healthcare Resources Prior to and During the COVID-19 Pandemic in an Urban, Tertiary Health System.pdf by Benjamin R. Kummer (9743116)

“…Older age (aOR 0.98, 97.5%CI 0.98–0.99), female sex (aOR 0.90 97.5%CI 0.83–0.99), and Medicaid insurance (aOR 0.78, 0.68–0.90) were associated with decreased odds of loss to follow-up.…”

Ras transformation affects the circadian clock via MAPK signalling. by Angela Relógio (193817)

“…(<b>B</b>) Western Blot analysis of RAS protein expression for the HaCaT cell lines and its derivatives (HaCaTI7, HaCaTII4, A5RT3), shows clear RAS overexpression measured in A5RT3. …”

Behavioral Logic for Operant Training and Discrimination Testing by Samar B Mehta (274037)

“…As this behavior was established, <i>N</i> was increased from 0.063 s to 1.5 s.</p> <p>(C) Stimulus training. All trials in this stage were initiated by a 1.5-s nose poke. …”

Low Health System Performance, Indigenous Status and Antivenom Underdosage Correlate with Spider Envenoming Severity in the Remote Brazilian Amazon by Vanderson Souza Sampaio (3167037)

“…Envenomings recorded from urban areas [Odds ratio (OR) = 0.40 (95%CI = 0.30–0.71; p<0.001)] and living in a municipality with a mean health system performance index (MHSPI >median [OR = 0.64 (95%CI = 0.39–0.75; p<0.001)] were independently associated with decreased risk of severity. …”

DTA-1-mediated depletion of tumor-infiltrating CD4⁺ Foxp3⁺ Treg cells by ADCC. by Mikiya Ishihara (611835)

“…<p>(A) DTA-1- (dotted line) or isotype control (solid line)-treated CMS5a and murine GITR gene-transfected CMS5a (CMS5a/GITR) cells were stained with a FITC-conjugated anti-rat IgG (H+L) antibody and analyzed by flow cytometry. …”

Supplementary Material for: Long-term trends in incidence, attack rates, and early case-fatality of spontaneous intracerebral hemorrhage. Dijon Stroke Registry (1985-2022) by figshare admin karger (2628495)

“…Results: 1,015 ICH cases (mean age 73.5 ±16.4 years old, 52.7% women) were recorded including 815 patients with a first-ever ICH and 200 cases of ICH as stroke recurrences. …”

Reappraisal of the Trophic Ecology of One of the World’s Most Threatened Spheniscids, the African Penguin by Maëlle Connan (680842)

“…The world population of the endangered African penguin <i>Spheniscus demersus</i> has decreased from more than 1.5 million individuals in the early 1900s to c.a. 23 000 pairs in 2013. …”

DHEA and DHEA8354 suppress the growth of mammary tumors by Anne Shilkaitis (15502)

Microparticle ADPase inhibition using anti-CD39 monoclonal antibody. by Scott H. Visovatti (153660)

Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies by John J. Chen (353023)