Representation of the GE356 Fab crystal structure and paratope mapping analysis. by Marjon Navis (92808)

“…The color-coding reflects fold-decrease in binding or of neutralization activity as compared to WT, in red (>50× WT), dark orange (20–50× WT), light orange (10–20× WT) and yellow (5–10× WT). …”

<i>Tle4</i> null mice have cell-intrinsic defects in HSPC self-renewal and B-cell development. by Justin C. Wheat (621068)

“…(d) Analysis of B-cell differentiation in the BM of recipient mice 32 weeks after transplant by quantitation of ProB Fractions shows an increase in Fraction C, but decreased Fractions D and E indicating a relative block in differentiation between Fractions C and D (n = 5 per genotype, *: <i>P</i><.05 analysis of bone marrow weeks after transplant showed no significant differences between ko and wt recipients in the absolute number lks clp cmp or gmp compartments but did show a decrease meps recipient mice. competitive homing hours transplantation using whole bm from two week old littermates defect ability index is represented as: input src="http://www.plosone.org/article/fetchObject.action?…”

Blockade of GKAP degradation prevents Aβ-induced actin cytoskeleton remodeling. by Francesco Roselli (211670)

“…Upon Aβ treatment, GKAP-WT cluster size decreased to 64.4±11.5% (p<0.05) of vehicle-treated control. …”

Upstream bubble collapse and transition into elongation are delayed in the P266L mutant. by Guo-Qing Tang (540328)

“…The number of DNA molecules that were analyzed to draw the smFRET histograms are as follows: P266L: 3110 at 1 min; 4164 at 5 min; 4883 at 33 min. WT: 3444 at 1 min; 3432 at 5 min; 5855 at 34 min. …”

Replication of challenge viruses in mice immunized with the VN1203ΔNS1 virus. by Julia Romanova (225341)

“…a<p>Mice with lung virus load <1.5 log₁₀ TCID₅₀/ml were classified as being protected.</p>b<p>The virus titers are expressed as the mean log₁₀ TCID₅₀/ml±standard error (S.E.) from 6 animals. …”

Visual phenotype of the <i>Fatp1</i>^−/− mouse. by Karim Chekroud (298429)

“…GCL: ganglion cell layer. WT: <i>Fatp1</i>^+/+. KO: <i>Fatp1^−/−</i>. …”

Viral stability of U_L26 recombinant viruses. by Chun Mathers (520324)

“…<p>(<b>A</b>) Replicate cultures of MRC5 fibroblasts were seeded with 25 plaque forming units of WT, 1^stmet Δ, 2^ndmet Δ, DBmetΔ, UL26TI, or #185stop virus that had been incubated at 37°C for 0, 4, 8, or 20 h. …”

Effect of Tdn and Jct on e-c coupling and ECCE. by Simona Boncompagni (105229)

“…Myotubes were loaded with 5 µM Fura-4F and exposed to increased concentrations of K⁺ for 5 s. …”

Exposure to estrogen or overexpression of Grx1 abolishes L-BOAA induced MMP loss in SH-SY5Y cells. by Uzma Saeed (49670)

Quantification of mast cells in Toluidine blue-stained skin sections from mock- and OVA-sensitized mice at the day of inoculation and 7 days after mock- or WR-inoculations. by Jarmila Knitlova (671387)

Impedimetric quantification of compound efficacy for tau-specific neurodegeneration attenuation and detection of toxic side effects. by Diana Seidel (122737)

“…</b> Scheme of impedimetric detection of tau-specific neurodegeneration by using our WT and K280q expressing SH-SY5Y 3D culture model. …”

Bone Marrow-Derived Matrix Metalloproteinase-9 Is Associated with Fibrous Adhesion Formation after Murine Flexor Tendon Injury by Alayna E. Loiselle (151690)

“…Adhesions persisted in WT, but were reduced in Mmp9^−/− mice by 21 days without any decrease in strength. …”

Supplementary Material for: White Tea Reduced Bone Loss by Suppressing the TRAP/CTX Pathway in Ovariectomy-Induced Osteoporosis Model Rats by Yıldırım M. (8994545)

“…The aim of this study was to investigate the potential anti-osteoporotic role of WT in ovariectomized (OVX) rats. WT was given orally at 0.5% w/v doses for 12 weeks in OVX rats. …”

Deletion of diploid-specific doxorubicin resistance genes result in cell cycle progression or recombination defects. by Tammy J. Westmoreland (38006)

“…Single unbudded (G1) cells were arrayed into 5×4 cell grids on YPD with and without doxorubicin (50 µg/ml). …”

Processing kinetics with wild type tRNase Z and Phe329Ala variant. by Makenzie Saoura (4521427)

“…(C-D) Michaelis-Menten kinetics experiments were performed using constant concentration of ³²P labeled substrate with added unlabeled substrate varied over a concentration range from 4.8–120 nM (shown below gel panels), with reactions incubated at 28°C and sampled after 5, 10, and 15 minutes. WT and F329A enzyme concentrations (shown above gel panels) were adjusted to obtain roughly equivalent product in the variant, here requiring an almost 1,000-fold higher concentration of F329A variant than WT. …”

Effects of Gβ5 and Gβ1 coexpression on agonist-induced receptor internalization. by J. Christopher Octeau (622081)

“…</b> Quantification of the relative levels of transiently expressed cell surface D2R in HEK293 cells expressing D2R alone, D2R and Gβ1 or D2R and Gβ5, after treatment of with dopamine (50 µM for 45 min). The bars represent the percentage decrease in cell surface D2R in each transfection condition compared to corresponding cells that were not treated with dopamine (mean ± SEM; n = 8, *p<0.01, t-test, compared to cell surface D2R signal from corresponding cells not treated with dopamine). …”

Lkb1-deficiency alters the expression of Notch signalling components and leads to the abnormal intestinal secretory cell differentiation. by Boris Y. Shorning (232815)

“…<p>A, Western blot analysis of Notch signalling effectors, Hes1 and Hes5 at day 6 in induced <i>Cre</i>-negative Lkb1 fl/fl (+/+) (lanes 1, 2) and Lkb1-deficient (‘−/−’) intestinal tissue (lane 3, 4), Hes5 expression has a notable increase. …”

Examples of sympathetic activity and ECG recording. by Adam Ali Ghotbi (797650)

Ursolic acid inhibits mitogen induced proliferation of CD4+ T cells, CD8+ T cells and B cell. by Rahul Checker (332303)

“…Percent daughter cells were calculated from decrease in mean fluorescence intensity. (B&D) Each bar represents percentage of daughter cells in different treatment groups. …”

Quantifying responses to MAPK inhibition at the single-cell level. by Matthew J. Harder (10005229)

“…In the fade model, expression loss at EC₅₀ involves a graded ~50% weakening of expression in all the expressing cells. …”