Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p by Josef Davidsson (87327)

“…The majority (89%) of the significantly deregulated genes were not situated on 12p, indicating that global perturbation of gene expression is a key pathogenetic event in PKS. Three genes—<i>ATP6V1G1</i> in 9q32, <i>GMPS</i> in 3q25.31, and <i>TBX5</i> in 12q24.21—exhibited concomitant hypermethylation and decreased expression. …”

Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage by Stephanie D. Kraft-Terry (87700)

“…Alterations in <i>de novo</i> protein synthesis of HIV-1 infected human monocyte-derived macrophages (MDM) were examined after 3, 5, and 7 days of viral infection. Synthesis rates of cellular metabolic, regulatory, and DNA packaging activities were decreased, whereas, those affecting antigen presentation (major histocompatibility complex I and II) and interferon-induced antiviral activities were increased. …”

Video1_Novel Biallelic Variant in the BRAT1 Gene Caused Nonprogressive Cerebellar Ataxia Syndrome.MP4 by Yiming Qi (780014)

“…Recently, attenuated disease variants have been described, suggesting that a wider clinical spectrum of BRAT1-associated neurodegeneration exists than was previously thought. Here, we reported a 10-year-old girl with severe intellectual disability, rigidity, ataxia or dyspraxia, and cerebellar atrophy on brain MRI; two BRAT1 variants in the trans configuration [c.1014A > C (p.Pro338 = ); c.706delC (p.Leu236Cysfs*5)] were detected using whole-exome sequencing. …”

LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization by Peng Huang (105814)

“…Recombinant LYZL6 (rLYZL6) reached its peak activity at pH 5.6 and 15 mM of Na⁺, and could inhibit the growth of Gram-positive, but not Gram-negative bacteria. …”

Reduction of rotavirus as a cause of nosocomial diarrhoea in northern Stockholm after introducing the rotavirus vaccine by Selma Olsson-Åkefeldt (11500789)

“…Of these, 401 (85%) occurred in children with chronic medical conditions. In children <5 years the rates of nosocomial rotavirus gastroenteritis, with 95% confidence intervals, significantly decreased from 0.34 (0.25—0.45) per 100 admissions prevaccination to 0.09 (0.04—0.17) postvaccination and from 0,66 (0.48—0.88) to 0.16 (0.07—0.30) cases per 1000 hospital days. …”

TIM-CLKGR flies display low amplitude circadian protein oscillations. by Ron Weiss (22503)

“…A representative VRI Western blot from TIM-CLKGR and control (<i>tim-gal4/+</i> and <i>UAS-ClkGR/+</i>) fly heads. We collected the samples at 6 time points during the first day in constant darkness (DD1). …”

Comorbidities and in-hospital death of viral pneumonia adults admitted to SUS (2002–2015) by Thais Piazza (6571460)

“…Results were quantified as incidence rate ratio (IRR) with 95% confidence intervals (CI), and we built five models using successive inclusion of variables blocks. …”

Periodic Ice Banding in Freezing Colloidal Dispersions by Anthony M. Anderson (2017657)

“…We discuss the implications of our experimental findings for theories of ice lensing.…”

Influence of Additional Gaussian Noises on Mixed Quantum-Classical Nonadiabatic Dynamics Simulations of Photoisomerization of <i>cis</i>-Azobenzene by Zihan He (3702544)

Data_Sheet_2_The Impact of Mercury Selection and Conjugative Genetic Elements on Community Structure and Resistance Gene Transfer.docx by James P. J. Hall (9207143)

“…Nevertheless, the introduced merA gene spread to a phylogenetically diverse set of recipients over the 5 weeks of the experiment, as assessed by epicPCR. …”

Effects of Varied Housing Density on a Hybrid Mouse Strain Followed for 20 Months by Beverly Paigen (18314)

“…<div><p>To evaluate the effect of increased housing density in a hybrid mouse strain, we evaluated a panel of physiological and behavioral traits in animals that were housed in groups of 3, 5, 8, or 12, using cages that provide 78.1 in² of floor space. …”

Image_3_Subchronic Toxicity of Microcystin-LR on Young Frogs (Xenopus laevis) and Their Gut Microbiota.TIF by Jinjin Li (849002)

“…MC-LR significantly decreased the activities of malondialdehyde and alkaline phosphatase and the expression of TGF-β in the liver. …”

Proteomic and Phosphoproteomic Changes Induced by Prolonged Activation of Human Eosinophils with IL‑3 by Stephane Esnault (24104)

“…To characterize this phenotype, we quantified protein abundance and phosphorylation by multiplexed isobaric labeling combined with high-resolution mass spectrometry. …”

Protective Effect of Combined Metoprolol and Atractylenolide I in Rats with Acute Myocardial Infarction via Modulation of the SIRT3/β-CATENIN/PPAR-γ Signaling Pathway by Weijian Zhou (1592806)

“…<div><p>ABSTRACT Herein, we examined the protective effect of metoprolol combined with atractylenolide I (Atr I) in acute myocardial infarction (AMI) by regulating the SIRT3 (silent information regulator 3)/β-catenin/peroxisome proliferator-activated receptor gamma (PPAR-γ) signaling pathway. …”

Spatio-Temporal Dynamics of Foraging Networks in the Grass-Cutting Ant <i>Atta bisphaerica</i> Forel, 1908 (Formicidae, Attini) by Juliane F. S. Lopes (845017)

“…The foraging networks consisted of underground tunnels which opened on average at 21.5m from the nests and of above-ground physical trails that reached on average 4.70m in length. …”

Supplementary Material for: Interleukin-17A Promotes Arginase-1 Production and 2,4-Dinitrochlorobenzene-Induced Acute Hyperinflammation in Human Papillomavirus E7 Oncoprotein-Expre... by Tran L.S. (3632413)

“…Further, blockade of either IL-17A or arginase activity alleviates DNCB-induced hyperinflammation through reduced recruitment of neutrophils, as a consequence of decreased CXCL1 and CXCL5 chemokine production. Thus, our findings suggest that increased IL-17A expression by macrophages in E7-expressing skin exposed to DNCB promotes arginase-1 induction and contributes directly to the observed hyperinflammation.…”

Image_6_The Impact of Mercury Selection and Conjugative Genetic Elements on Community Structure and Resistance Gene Transfer.JPEG by James P. J. Hall (9207143)

“…Nevertheless, the introduced merA gene spread to a phylogenetically diverse set of recipients over the 5 weeks of the experiment, as assessed by epicPCR. …”

<em>Foxa1</em> and <em>Foxa2</em> Are Required for Formation of the Intervertebral Discs by Jennifer A. Maier (278698)

“…Using a conditional <em>Foxa2</em> allele in conjunction with a tamoxifen-inducible <em>Cre</em> allele (<em>ShhcreER^T2</em>), we removed <em>Foxa2</em> from the notochord of E7.5 mice null for <em>Foxa1</em>. …”

Image_7_Subchronic Toxicity of Microcystin-LR on Young Frogs (Xenopus laevis) and Their Gut Microbiota.TIF by Jinjin Li (849002)

“…MC-LR significantly decreased the activities of malondialdehyde and alkaline phosphatase and the expression of TGF-β in the liver. …”

Non-invasive hypoglycemia detection in people with diabetes using smartwatch data by Vera Lehmann (9383845)

“…Using this data, we developed a machine learning (ML) approach to detect hypoglycemia (<3.9 mmol/L) non-invasively on unseen individuals and solely based on wearable data.…”