MPA and tacrolimus act differentially on the polarization of M1 and M2 macrophages. by Nynke M. Kannegieter (3697594)

“…Tacrolimus changed the expression of M2 markers under a M1-driven condition and decreases the expression of M1 markers under M2 conditions. …”

Tau overload causes behavioral deficits and maintains neurodegeneration at older ages. by Kaushik Ghosal (244754)

“…<p>A. hTau animals also showed decreased working memory as measured by deficits in spontaneous alternations compared to age-matched wild-type animals. …”

MEKi inhibits growth and ablates MAPK regardless of <i>PIK3CA</i>^<i>mut</i> status. by Robert S. McNeill (5485064)

“…<p>Selumetinib IC₅₀ were similar regardless of <i>PIK3CA</i>^<i>mut</i> status in NHA (<b>A</b>), but slightly higher in most <i>PIK3CA</i>^<i>mut</i> NHA^RAS compared to parental cells (*, P≤0.03) (<b>B</b>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200014#pone.0200014.s011" target="_blank">S11 Fig</a></b>). …”

SC-1 Inhibited RSK2 Kinase Activity <i>in vitro</i> and an RSK2 Inhibitor Increased Colony Formation. by Susan D. Mertins (380936)

“…<p>COLO 205 tumor cell line was treated with SL0101 (1.25 µM) and SC-1 (0.1 µM) for 24 hrs prior to soft agar cloning, lysate preparation, and immunoblotting. A. SC-1 inhibited RSK2 N-terminal domain <i>in vitro</i> kinase activity with an EC₅₀ of 2.5±1.8 µM (mean±SD, n = 5) but not in other like assays for Aurora kinase B, CHK1, or CHK2 kinases. …”

SS inhibits breast cancer growth <i>in vivo</i>. by Zhiyu Wang (282312)

“…The results indicated that LDH-A expression in both SS-treated breast cancer xenografts were significantly reduced, while TUNEL analysis indicated that the apoptosis ratio in SS –treated tumor samples was significantly increased. (×100, scale bar = 50 um; All values represents as Mean±SD, n = 6, *<i>P</i><0.05 <i>vs.…”

Table 1_Role of seed priming using natural biostimulants in reducing salt stress effects by reshaping physio-biochemical and antioxidant defense systems in glycine max seedlings.do... by Mostafa M. Rady (14004633)

“…<p>Abiotic stress significantly damages crops, reducing global yields by over 50%. Among these challenges, salt stress poses a critical constraint that severely affects the growth, productivity, and quality of soybeans in various regions worldwide. …”

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age by Delio Eulalio Martins (5759282)

“…</p><p>Results</p><p>The old-aged group showed a decrease in content of sulphated and non-sulphated glycosaminoglycans relative to middle-aged and there were also alterations in the proportion of GAG disaccharides and a decrease of collagen fiber size. …”

Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores by Bethany R. Hood (20396768)

Brivanib inhibits liver fibrosis induced by thioacetamide. by Ikuo Nakamura (548298)

“…(B) The number of bands of bridging fibrosis per high power field were counted in images obtained at 100× magnification after Sirius red staining. There was a significant decrease in the number of bands in both the 25 mg/kg and 50 mg/kg brivanib groups, compared to placebo. …”

Collagen XVI overexpression leads to an increase of ILK/kindlin-1 interaction. by Konstanze B. Bedal (513309)

“…<p>(<b>A</b>) Proximity ligation assay for the analysis of ILK/kindlin-1 interaction in COLXVI and mock control cells (scale bar equals 50 µm). …”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Furthermore this increase in [Ca²⁺]_c is associated with a reduction in ΔΨ_m. Application of 50 mM KCl induces a further rise in [Ca²⁺]_c and profound mitochondrial depolarisation. …”

Distribution of estimated parameters by the three approaches with only 3 recorded responses. by Alireza Ghadimi (13839874)

“…The dual optimization approach improved the estimation precision by decreasing the standard deviation of the PDF and moving the mean of the PDFs closer to the true values. …”

GPI anchored proteins are required for neural differentiation. by Xuan Yuan (225365)

“…Neural induction and rosette formation upon neural induction was assessed in three cell lines using a serum-free EB generation method. On day 2 (left) of hiPSC-derived EBs from <i>PIGA</i>wt, <i>PIGA</i>c.1234C>T, and <i>PIGA</i>null after forced aggregation (20X magnification, scale bar is 50μm). …”

Data overview for continuous imagery duration. by Daphne Cuvelier (561619)

Relationships between leaf toughness and litter chemical trait changes (as fractions of final / initial) in amounts or in concentrations under different environment conditions. by Xu Pan (517723)

Correlation between stored patterns affects sequence completion in the DDN model. by Mehdi Bayati (5819342)

Figure 7 by Guadalupe Arzadun (7251194)

Example of an mNP patient. by Mammar Hachemi (520328)

Silencing expression of Foxo1 increases Na_V1.5 expression. by Weike Mao (181121)

“…<p>Western blots showed decrease of Foxo1 protein by 50 MOI (n = 4) and 100 MOI Adv-Foxo1 RNAi (n = 4) increased Na_V1.5 protein in HL-1 cells in comparison with 100 MOI Adv-scramble RNAi (n = 4) (A) and this inhibition reached the significant difference (*p<0.05) at 100 MOI Adv-Foxo1-RNAi (C). …”

Nucleotide and amino acid changes and in vivo phenotypes of <i>mip1</i> mutants. by Françoise Foury (196285)