Drug repositioning against COVID-19: a first line treatment by Nousheen Bibi (446289)

“…Further through molecular dynamics simulation, critical conformational changes in the target protein molecules were revealed upon drug binding which illustrates the favorable binding conformations of antiviral drugs against SARS-CoV-2 target proteins. The resulting drugs from the present study in combination and in cocktails from the arsenal of existing drugs could reduce the translational distance and could offer substantial clinical benefit to decrease the burden of COVID-19 illness. …”

Pirfenidone for Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis by Carlos Aravena (787791)

“…Also there was a decrease in progression free survival (PFS) (RR 0.83 IC 0.74–0.92) compared to placebo. …”

Data Sheet 1_SARS-CoV-2 Nsp7 plays a role in cognitive dysfunction by impairing synaptic plasticity.docx by Jiazheng Guo (14799721)

“…Initially, we confirmed a reduction in the level of synaptic proteins in SH-SY5Y neurons following SARS-CoV-2 infection. …”

RhoA GTPase positively and transcriptionally controls CD70 membrane and global expression. by Christine Pich (367328)

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Simultaneously Enhancing Mechanical Strength, Toughness, and Fire Retardancy of Biobased Polyurethane by Regulating Soft/Hard Segments and Crystallization Behavior by Weijun Yang (560411)

“…Furthermore, the LOI value of FRBPU-0.5P reached 29.6%, and this material achieved a UL-94 V-0 rating. …”

Household Water Chlorination Reduces Incidence of Diarrhea among Under-Five Children in Rural Ethiopia: A Cluster Randomized Controlled Trial by Bezatu Mengistie (234272)

“…<div><p>Background</p><p>Household water treatment has been advocated as a means of decreasing the burden of diarrheal diseases among young children in areas where piped and treated water is not available. …”

Fig 4 - by Chengyu Wu (640314)

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The combination of indisulam and melphalan inhibits MM cell proliferation and induces cell apoptosis and DNA damage. by Chengyu Wu (640314)

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Fig 1 - by Chengyu Wu (640314)

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Combinatorial treatment delays MM growth in vivo. by Chengyu Wu (640314)

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Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect by Tzu-Chun Chen (787255)

“…However, the abundance of HCV RNA carrying mutations on both miR-122-binding sites and whose stability was supported by ectopically expressed miR-122 mimetics with compensatory mutations also decreased in Rab27a-depleted cells. This result indicates that the effect of Rab27a depletion on HCV RNA abundance does not depend on the formation of 5’ terminal HCV/miR-122 RNA complexes, but that miR-122 has a Rab27a-dependent function in the HCV lifecycle, likely the downregulation of a cellular inhibitor of HCV gene expression. …”

Effect of telomerase siRNA transfection on AFP production by HepG2/C3A and PLC/PRF/5 cells. by Roula Tahtouh (714734)

“…After incubation, 50 μL of the supernatant was collected and tested by ELISA for AFP quantification. (A) The inhibition of telomerase by hTERT siRNA induced a decrease in AFP production by HepG2/C3A cells. …”

<i>Rpl5</i> mutant ES cells exhibit a p53-independent G2 cell cycle arrest. by Sharon A. Singh (524066)

“…In contrast, the cell cycle profile of the <i>Rpl5</i> mutant ES cells exhibited a three-fold increase in the G2 phase with a concomitant decrease in the G1 and S phases, consistent with a delayed G2 phase transition (A, C) (three independent pooled experiments). …”

Next-generation sequencing analyses of parental and mutant MeV stocks documenting the stability of the introduced mutations. by Lorellin A. Durnell-Bettis (22656332)

miRNA Expression Analysis of IPEC-J2 Cells Damaged by Soybean 7S Globulin Reveals ssc-miR-221-5p as the Factor Alleviating Cell Damage by Huidan Deng (7330031)

“…Therefore, we conducted a preliminary study on the mechanisms of ssc-miR-221-5p in soybean 7S globulin-injured IPEC-J2 cells. …”

Image_5_Rice OseIF6.1 encodes a eukaryotic translation initiation factor and is essential for the development of grain and anther.jpeg by Hongming Guo (13166058)

Supplemental Figures 1-5 from LEF1 Targeting EMT in Prostate Cancer Invasion Is Regulated by miR-34a by Jiaqian Liang (15079825)

“…<p>Supplemental Figures 1-5. Supplemental Figure 1. Expression levels of miR-34a, miR-1260, miR-206, miR-93, miR-324-3P andmiR-324-5P in four (LNCaP, LNCaP-LEF1, LNCaP-AI, LNCaP-AILEF1shRNA) PCa cell lines by real time qRT-PCR. …”