Finite mixture model with a beta-binomial distribution of errors exploring the effect of duration of symptoms, incubation period and whether pathogens induce a local or a systemic... by Gabriele Sorci (288219)

Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL by Michael J. Ricciardi (4102375)

“…We collected blood from a female with a maculopapular rash at day (D) 5 and D7 post onset of symptoms (POS) and we continued weekly blood draws out to D148 POS. …”

Stability study results of a) & b) are ACE and CAP at 40°C±2°C/75%RH±5%RH, c) & d) are ACE and CAP at 25°C±2°C/60%RH±5%RH, e) & f) are ACE and CAP at 2–8°C. by Jaganmohan Somagoni (532859)

Silencing TRPM7 in Mouse Cortical Astrocytes Impairs Cell Proliferation and Migration via ERK and JNK Signaling Pathways by Zhao Zeng (478844)

“…Knocking down TRPM7 with specific siRNA impairs the proliferation and migration of astrocytes by 40.2% ± 3.9% and 40.1% ± 11.5%, respectively. Consistently, inhibition of TRPM7 with 2-aminoethoxydiphenyl borate (2-APB) also decreases astrocyte proliferation and migration by 46.1% ± 2.5% and 64.2% ± 2.4%. …”

VEGFa, VEGFR1 and VEGFR2 mRNA levels following A2E incubation and/or light exposure. by Mélanie Marie (7535228)

Conditional <i>Cdk5rap2</i> KO mouse and novel <i>mCdk5rap2</i> splice variants. by Nadine Kraemer (790327)

“…(D) Identification of a novel <i>mCdk5rap2</i> splice variant (<i>mCdk5rap2-V1</i>) through gel electrophoresis and sequencing of PCR products from exon 2 to exon 7 of WT and hom KO cDNA. …”

Percent decrease of the marker pigment concentrations (mean ± standard deviation of triplicate microcosms, and the probability) treated with 1.6 mg L⁻¹ H₂O<su... by Varunpreet Randhawa (302690)

Metaphase spindles arise earlier in <i>yhp1-13A yox1-9A</i> cells compared to wild type. by Michelle M. Conti (13514386)

Stem Cell-Derived, microRNA-Carrying Extracellular Vesicles: A Novel Approach to Interfering with Mesangial Cell Collagen Production in a Hyperglycaemic Setting by Sara Gallo (3111309)

“…This resulted in STAT5 down-regulation and a decrease in miR-21 content, TGFβ expression and matrix protein synthesis within MCs. …”

Heavy metal EF values in five soil profiles. by Ziqi Li (7154915)

“…Except for profile HCZK02, the contents of 8 heavy metals generally decrease with increasing depth. As the depth of profile HCZK02 increases, As, Hg and Pb show a decrease-increase-decrease change; Cd and Cr show a decrease change and Ni shows a zigzag change; Cu and Zn show a decreasing-increasing-decreasing-increasing trend. …”

Interactomes of HMR/LHR interactors provide evidence for the existence of a defined HMR protein complex (related to Fig 1). by Andrea Lukacs (3752956)

Performance of the model with the inhibitory V0_D pathways removed. by Yaroslav I. Molkov (542831)

“…Decreasing <i>α</i> causes two bifurcations: (i) transition from symmetric alternations of flexor activity, i.e. with a phase difference of Δ<i>φ</i> = 0.5, to alternations with a phase difference of Δ<i>φ</i> ≠0.5 at X₇ and then (ii) from alternation to synchronization of flexor activity at X₆. …”

Image_5_Changes in BMI and physical activity from youth to adulthood distinguish normal-weight, metabolically obese adults from those who remain healthy.tif by A. Viitasalo (13224681)

Overexpression of tau inhibited whole-cell currents through Kv channels. by Xiantao Li (683919)

“…<p>(A) The outward Kv currents were evoked by stepped up to +60 mV for 500 ms at a holding potential of -80 mV in N2A cells. …”

Pig growth over the course of the experiment. by James H. Bishop (2182486)

Table 1_Cannabidiol reduces synaptic strength and neuronal firing in layer V pyramidal neurons of the human cortex with drug-resistant epilepsy.docx by Vladimir A. Martinez-Rojas (21758372)

“…At the cellular level, whole-cell patch-clamp recordings showed that CBD decreased the excitability of layer V pyramidal neurons, as evidenced by changes in the somatic input resistance, the membrane time constant, the hyperpolarization-induced “sag” conductance, the rheobase current needed to elicit an action potential, and the firing discharge in response to depolarizing current steps. …”

Synonymous Rare Arginine Codons and tRNA Abundance Affect Protein Production and Quality of TEV Protease Variant by Jie Fang (306330)

“…<div><p>It has been identified that a TEV protease (TEVp) variant, TEVp^5M, displays improved solubility. …”

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Changes after 45 minutes in the proportion of LTP, LTD or no plasticity responses observed in L5PyNs population induced by the HFS protocol in the presence of D1R agonist or antago... by Claire Nicole Jeanne Meunier (703124)

“…<p>(A and D) Percentages of L5PyNs displaying LTP, LTD or no plasticity in 129/Sv mice and 5-HT_1AR-KO mice in control conditions. …”

Exemplar display during target selection. by Joshua B. Moskowitz (8506380)