Image_1_The Association of Real-World CA 19-9 Level Monitoring Patterns and Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma.tif by Ben George (64738)

“…Patients with normal baseline CA 19-9 experienced longer median survival than patients with elevated levels [1L: 8.8 months (95% CI: 7.9 - 10) vs. 7.2 months (6.8 – 7.5), p < 0.001; 2L: 7.2 months (6.1 – 9.2) vs. 5.2 months (4.9 – 5.6), p < 0.001; 3L: 6.1 months (5.4 – 9.1) vs. 3.9 months (3.4 – 4.3), p < 0.001]. Patients with decreasing/stable CA 19-9 during treatment experienced longer survival than patients who experienced an increase in CA 19-9 levels [1L: 10.9 months (10.5 – 11.3) vs. 5.4 months (5.1 – 5.9), p < 0.0001; 2L: 8.2 months (7.7 – 8.5) vs. 4.3 months (4.1 – 4.7), p < 0.001; 3L: 7.5 months (6.6 – 9.2) vs. 3.7 months (3.4 – 4.3), p < 0.001].…”

Image_2_The Association of Real-World CA 19-9 Level Monitoring Patterns and Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma.tif by Ben George (64738)

“…Patients with normal baseline CA 19-9 experienced longer median survival than patients with elevated levels [1L: 8.8 months (95% CI: 7.9 - 10) vs. 7.2 months (6.8 – 7.5), p < 0.001; 2L: 7.2 months (6.1 – 9.2) vs. 5.2 months (4.9 – 5.6), p < 0.001; 3L: 6.1 months (5.4 – 9.1) vs. 3.9 months (3.4 – 4.3), p < 0.001]. Patients with decreasing/stable CA 19-9 during treatment experienced longer survival than patients who experienced an increase in CA 19-9 levels [1L: 10.9 months (10.5 – 11.3) vs. 5.4 months (5.1 – 5.9), p < 0.0001; 2L: 8.2 months (7.7 – 8.5) vs. 4.3 months (4.1 – 4.7), p < 0.001; 3L: 7.5 months (6.6 – 9.2) vs. 3.7 months (3.4 – 4.3), p < 0.001].…”

Gender-Specific Effects of Genetic Variants within Th1 and Th17 Cell-Mediated Immune Response Genes on the Risk of Developing Rheumatoid Arthritis by Rafael Cáliz (452151)

“…In men, carriers of the <i>DC-SIGN</i>_rs2287886A allele had an increased risk of RA (OR = 1.70, 95%CI 1.03–2.78), whereas carriers of the <i>DC-SIGN</i>_rs4804803G had a decreased risk of developing the disease (OR = 0.53, 95%CI 0.32–0.89). …”

Space-based scanpath model design. by Nicolas Roth (11568286)

“…The frame-wise saliency maps are multiplied with a generic center bias [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011512#pcbi.1011512.ref059" target="_blank">59</a>]. …”

DataSheet_1_Hyperthyroidism Prevalence in China After Universal Salt Iodization.docx by Chuyuan Wang (10889535)

“…OH and GD prevalence were higher in women than in men (OH: 1.16% vs. 0.64%, P<0.001; GD: 0.65% vs. 0.37%, P<0.001).Prevalence was significantly decreased after 60 years-of-age compared with 30–39 years-of-age (OH:0.61% vs. 0.81%, P<0.001; GD: 0.38% vs. 0.57%, P<0.001).Excessive iodine(EI) and deficient iodine(DI) were both related to increased prevalence of OH (odds ratio [OR] 2.09, 95% confidence interval [CI] 1.68–2.59; OR1.35, 95%CI 1.07–1.72, respectively); however, only deficient iodine was associated with increased prevalence of GD (OR1.67, 95%CI 1.30–2.15). …”

Supplementary file 1_Persistent burden and health inequalities of disease in women of childbearing age attributable to Intimate Partner Violence, 1990–2021.docx by Yingda Song (15410321)

“…The absolute value of the SII for ASMR increased from 2.04 in 1990 to 4.59 in 2021, while that of the SII for ASDR decreased from 321 in 1990 to 190 in 2021. …”

The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers by Kristian Magnus Gundersen (7382027)

“…Measurements were taken at baseline; before a 5-min suprasystolic forearm occlusion; and following a 3-min post-occlusion, to measure reactive hyperemia and FMD.…”

DataSheet_1_Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases.docx by Yingjie Li (2106778)

“…Higher levels of educational attainment decreased risks of psoriasis (OR = 0.61, 95% CI = 0.52-0.72, p = 1.12×10^-9), RA (OR = 0.68, 95% CI = 0.59-0.79, p = 1.56×10^-7), and hypothyroidism (OR = 0.80, 95% CI = 0.72-0.88, p = 5.00×10^-6). …”

DataSheet_2_Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases.xlsx by Yingjie Li (2106778)

“…Higher levels of educational attainment decreased risks of psoriasis (OR = 0.61, 95% CI = 0.52-0.72, p = 1.12×10^-9), RA (OR = 0.68, 95% CI = 0.59-0.79, p = 1.56×10^-7), and hypothyroidism (OR = 0.80, 95% CI = 0.72-0.88, p = 5.00×10^-6). …”

Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer by Justin C. Brown (185942)

“…Over six months, significant decreases in CTCs were observed in the low-dose (−1.34±0.34; <i>P</i><0.001) and high-dose (−1.18±0.40; <i>P</i> = 0.004) exercise groups, whereas no significant change was observed in the control group (−0.59±0.56; <i>P</i> = 0.292). …”

Postoperative complications and mortality [n(%)]. by Qingwen Cao (22439195)

“…There was a higher proportion of femoral neck fractures in the YO group and a higher incidence of intertrochanteric fracture in the OO group (<i><i>P</i> <i><</i></i> 0.001). …”

Information of surgery and anesthesia [n(%)]. by Qingwen Cao (22439195)

“…There was a higher proportion of femoral neck fractures in the YO group and a higher incidence of intertrochanteric fracture in the OO group (<i><i>P</i> <i><</i></i> 0.001). …”

Raw data. by Qingwen Cao (22439195)

“…There was a higher proportion of femoral neck fractures in the YO group and a higher incidence of intertrochanteric fracture in the OO group (<i><i>P</i> <i><</i></i> 0.001). …”

Relationship between YAP N/C ratio and cell spreading states of single B2B cells on 2-kPa hydrogels substrates. by Qin Luo (2182514)

“…<p>(<b>A</b>) 3D fluorescent confocal YAP image stack of a single spreading B2B cell on 2-kPa substrate at 0.5^th, 5^th, and 10^th hour. …”

DataSheet1_Quantifying the impact of novel metastatic cancer therapies on health inequalities in survival outcomes.pdf by Karolina Zebrowska (17444970)

“…In terms of PFS, the increases in survival inequalities were larger in a relative sense compared with OS. For mBC, PFS inequalities increased by 8.7 (5.9; 11.6) months, or 71.7%, for stratification based on 5 groups; the IG increased by 2.0 (1.3; 2.6) months, or 67.6%. …”

Data_Sheet_1_Association of maternal education, neighborhood deprivation, and racial segregation with gestational age at birth by maternal race/ethnicity and United States Census r... by Anne L. Dunlop (4682503)

“…Those with a high school diploma or less also had an increased odds of preterm (aOR 1.59, 95% CI: 1.20, 2.10) and early term birth (aOR 1.26, 95% CI: 1.05, 1.51). …”

Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis by Oonagh E. Keag (4789215)

“…Children delivered by cesarean delivery had increased risk of asthma up to the age of 12 years (OR 1.21, 1.11 to 1.32; <i>n</i> = 887,960; 13 studies) and obesity up to the age of 5 years (OR 1.59, 1.33 to 1.90; <i>n</i> = 64,113; 6 studies). …”

H2AK119ub is depleted from facultative heterochromatin as the cerebellum matures. by Aditya Parmar (22331873)

“…<b>(C)</b> Heatmaps depicting H2AK119ub CUT&RUN data in the early and late cerebellum centered around H3K27me3 peak summits identified by MACS2 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011843#pgen.1011843.ref059" target="_blank">59</a>] narrow in the early cerebellum. …”

<b>Targeted Metabolomic Profiling Reveals Inflammation – Associated longitudinal</b><b>changes in Plasma Metabolites Following on-pump Coronary Bypass Surgery</b> by Frieder Neu (18393729)

Inhibition of the RSK signaling prevents C/EPBβ phosphorylation and stimulates apoptosis in activated lung myofibroblasts. by Martina Buck (82941)

“…<p><b>A.</b> Immunoblots for RSK, C/EBPβ-phospho-Thr217, procaspase 8 and C/EBPβ were performed on C/EBPβ immunoprecipitates from activated primary human LMF lysates as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025497#s4" target="_blank">Methods</a>. …”