Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer by Giorgia Urbinati (554921)

“…Two of the five siRNAs tested were found to efficiently inhibit mRNA of both <i>TMPRSS2-ERG</i> variants and to decrease ERG protein expression. …”

Deficiency in ArgEF or CpcA but not ArgB decreases the cellular ornithine content. by Nicola Beckmann (194193)

Overexpression of E2 decreases ORC2 occupancy at a known mammalian origin. by Marsha DeSmet (2513767)

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. by Brendan J. Tunstall (6593357)

“…(A, Bottom) Oxytocin decreased sIPSC amplitude from baseline in CeA neurons from both nondependent and dependent rats and caused a small increase from baseline in sIPSC rise time in nondependent rats. …”

Expression of a phosphomimetic Hcm1 mutant decreases fitness in LiCl stress. by Michelle M. Conti (13514386)

eNOS phosphorylation increased intracellular ROS generation and decreased cell viability in BH4-depleted cells. by Hu Peng (396074)

“…<p>(A) HEK 293 cells were treated with DMSO or 10mM DAHP for 24 hours to deplete BH4, then transfected with either control vector or WT eNOS plasmid DNA overnight. …”

Influence of Acidic pH on Hydrogen and Acetate Production by an Electrosynthetic Microbiome by Edward V. LaBelle (608387)

“…Cyclic voltammetry revealed a 250 mV decrease in hydrogen overpotential and a maximum current density of 12.2 mA/cm² at −765 mV (0.065 mA/cm² sterile control at −800 mV) by the <i>Acetobacterium</i>-dominated community. …”

siRNA oligonucleotide specific for PKA causes decreased expression and activity of PKA and ameliorated the high glucose mediated decrease of G6PD activity. by Zhaoyun Zhang (118032)

“…In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0049128#pone-0049128-g005" target="_blank">figure 5C</a>, BAEC were transfected with duplex siRNA targeted against PKA (PKA siRNA) or a random sequence (scramble siRNA), after 24 hours, medium was switched to DMEM with 1% serum plus 5.6 mM glucose or 25 mM glucose for 72 hours. …”

HRMECs treated with SUZ12 siRNA demonstrate increased miR-200b expression, decreased VEGF expression and decreased endothelial branching. by Michael Anthony Ruiz (726055)

“…However, transfection of SUZ12 siRNA significantly reduced endothelial branching compared to HG+control siRNA. [NG+control siRNA = 5mM D-glucose + 100nM control siRNA, HG+control siRNA = 25mM D-glucose + 100nM control siRNA, HG+EZH2 siRNA = 25mM D-glucose + 100nM EZH2 siRNA, HG+SUZ12 siRNA = 25mM + 100nM SUZ12 siRNA; identical letters represent groups that are not significantly different; p < 0.05; n = 6; data expressed as mean ± SEM, normalized to U6 or β-actin and expressed as a fold change of NG+control siRNA].…”

Effect of pyruvic acid on ATP production and A1254-induced decrease of membrane mitochondrial potential (mΔΨ) in SH-SY5Y cells. by Stefania Cocco (759155)

Delphinidin alters VEGF-A splicing to increase VEGF-A₁₆₅b and decrease total VEGF-A expression. by Megan Stevens (3964886)

“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A₁₆₅b relative to total VEGF-A₁₆₅ (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A₁₆₅b before stripping and reprobing with panVEGF-A). …”

DHT increases whereas orchidectomy decreases the seminal vesicle weight in wild-type and SOD1-G93A mice. by Young-Eun Yoo (323357)

“…Representative pictures of the seminal vesicles are shown. Scale bar = 5 mm.</p>…”

Data_Sheet_5_Chemical Similarity of Co-occurring Trees Decreases With Precipitation and Temperature in North American Forests.CSV by Brian E. Sedio (10875330)

“…In contrast, chemical similarity of co-occurring species decreased with both MAT and MAP, and metabolite richness increased with MAT. …”

Stabilization of Hif-1α at early stages of infection leads to a decrease in bacterial burden. by Philip M. Elks (324793)

“…<p>(A) Quantification of bacterial burden by fluorescent pixel count after DMOG treatment between 5 and 6 dpi. …”

Graphs showing the mean temperature increase at the positions with the highest mean temperature increase for the MIPS (A) and MONO (B) systems and three drilling protocols (DP1, DP... by Marsel Ganeyev (21453399)

A chronic high glucose treatment decreases proteasome activities and increases apoptosis in human islets. by Christophe Broca (538652)

<i>Trappc9</i> deficient mice show a decrease in brain weight and size. by Zhengzheng S. Liang (9333660)

Topical application of ATX inhibitor (S32826) decreases IOP in rabbits. by Padma Iyer (141117)

“…A. 10 mM S32826 exhibited the maximum and statistically significant effect in lowering IOP (by 5–6 mm Hg; n = 9) with drug application at 0 and 5 hrs (indicated with arrows, 35 µl×2) relative to sham controls receiving pH adjusted water. …”

Decrease in optical density of <i>gerP</i> mutants in L-alanine and inosine. by Katherine A. Carr (259428)

“…a<p>Spores were incubated in 0.5 mM L-alanine and 1 mM inosine. ∼65% decrease in OD₆₀₀ represents ∼100% germination. …”

Chemically inhibiting LDHA or PDK1 decreases cell viability in Aβ resistant cells. by Jordan T. Newington (223389)

“…Similarly, 48 hr Aβ exposure significantly decreased cell viability in both PC12 (<b>C</b>) and B12 (<b>D</b>) resistant lines when cells were co-treated with 2.5 mM dichloroacetate (DCA), a chemical inhibitor of PDK1 (*P<0.01). …”