Image 2_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.jpg by Paolo Romania (399007)

“…PLAC1 and DSG2 expression in healthy tissues and NK cells was obtained from the HPA database and a GEO dataset.</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in <i>Saccharomyces cerevisiae</i> by Christine E. Cucinotta (779688)

“…<i>cerevisiae</i>. Specifically, we performed a synthetic lethal screen with cells lacking <i>RKR1</i> and a comprehensive library of H2A and H2B residue substitutions, and identified H2A residues that are required for H2B K123ub. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner by Josephe A. Honorat (339574)

“…<div><p>Oxidative stress and mitochondrial dysfunction are important determinants of neurodegeneration in secondary progressive multiple sclerosis (SPMS). We previously showed that febuxostat, a xanthine oxidase inhibitor, ameliorated both relapsing-remitting and secondary progressive experimental autoimmune encephalomyelitis (EAE) by preventing neurodegeneration in mice. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

<i>Pseudomonas aeruginosa serA</i> Gene Is Required for Bacterial Translocation through Caco-2 Cell Monolayers by Masashi Yasuda (3612797)

“…<div><p>To specify critical factors responsible for <i>Pseudomonas aeruginosa</i> penetration through the Caco-2 cell epithelial barrier, we analyzed transposon insertion mutants that demonstrated a dramatic reduction in penetration activity relative to <i>P</i>. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Here, we present engineering of a biocompatible self-assembled lithocholic acid-dipeptide derived hydrogel (TRI-Gel) that can maintain sustained delivery of antiproliferating doxorubicin, antiangiogenic combretastatin-A4 and anti-inflammatory dexamethasone. …”

Further characterizations of iPSC-derived midbrain neural cell types using the longer neural induction and regional patterning protocol. by Rhea Sullivan (18824253)

Identity in Family Firms: A Theoretical Analysis of Incentives and Contracts by Marcelo Sanches Pagliarussi (10413760)

“…<div><p>Abstract We developed a principal-agent model that coherently and parsimoniously explains previous findings from research on executive compensation in family firms. …”

Aβ induces the dispersal of Shank1 synaptic clusters. by Francesco Roselli (211670)

“…(A, B) Quantification of Shank1 clusters revealed a significant decrease in average size within 1 h of treatment with Aβ (77.6±9.4% vs. control; p<0.05); a similar decrease was seen after 6 and 24 h (74.5±3.6% and 64.4±5.8% of control, respectively; p<0.05). …”

DataSheet1_Efficacy of a paper-based interleukin-6 test strip combined with a spectrum-based optical reader for sequential monitoring and early recognition of respiratory failure i... by Cheng-Han Chen (15414512)

“…Respiratory failure was associated with a higher mortality rate (p = 0.015). Decreased serum IL-6 concentration within 24 h after admission indicated a lower risk of developing respiratory failure in the later admission course (Receiver Operating Characteristic [ROC] curve = 0.696).…”

DataSheet1_Efficacy of a paper-based interleukin-6 test strip combined with a spectrum-based optical reader for sequential monitoring and early recognition of respiratory failure i... by Cheng-Han Chen (15414512)

“…Respiratory failure was associated with a higher mortality rate (p = 0.015). Decreased serum IL-6 concentration within 24 h after admission indicated a lower risk of developing respiratory failure in the later admission course (Receiver Operating Characteristic [ROC] curve = 0.696).…”

Nutritional stress targets LeishIF4E-3 to storage granules that contain RNA and ribosome components in <i>Leishmania</i> by Rohit Shrivastava (6459608)

“…We hypothesize that each is responsible for a different function during the life cycle. …”

A <i>Clostridium difficile</i> Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence by Michele Chu (731561)

“…<i>difficile</i> infection is unknown. We explored the contribution of a conserved CWG locus to <i>C</i>. …”