The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance <i>In Vitro</i> and <i>In Vivo</i> Derived from Human Breast MCF-7/ADR Cells by Long Wu (655081)

“…Multidrug resistance reversal by 3-Bromopyruvate occurred through at least three approaches, namely, a decrease in the intracellular level of ATP and HK-II bioactivity, the inhibition of ATPase activity, and the slight decrease in P-glycoprotein expression in MCF-7/ADR cells.…”

Protein and mRNA noise are inversely correlated with abundance. by Roy D. Dar (816541)

PowerPoint Slides for: Urinary Periostin Excretion Predicts Renal Outcome in IgA Nephropathy by Hwang J.H. (3300987)

“…Histologically, group 3 patients were correlated with severe interstitial fibrosis/tubular atrophy (p = 0.004), interstitial inflammation (p = 0.007), hyaline arteriolosclerosis (p = 0.001) and glomerular sclerosis (p < 0.001). A higher initial uPOSTN/Cr level was associated with a greater decline in eGFR during follow-up (p = 0.043 when initial eGFR ≥60; p = 0.025 when eGFR <60 ml/min/1.73 m2), and the renal outcomes with end-stage renal disease (ESRD; p = 0.003), ESRD and/or eGFR decrease of >30% (p = 0.033) and ESRD and/or eGFR decrease of >50% (p = 0.046) occurred significantly more in group 3. …”

Trichopsistides A and B: Two Highly Oxygenated Pentacyclic Polyketides with Promising Inhibitory Effects on the NF-κB Signaling Pathway from the Fungus <i>Trichoderma koningiopsis<... by Li Feng (77923)

“…Two highly oxygenated pentacyclic polyketides with two new carbon skeletons, trichopsistide A (<b>1</b>) and trichopsistide B (<b>2</b>), were isolated from the plant endophyte <i>Trichoderma koningiopsis</i> WZ-196 derived from the leaf of <i>Rubia podantha</i> Diels. …”

Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome by Heon Shin (4559110)

“…Surprisingly, in ALDH6A1-O/E cells, NO was decreased nearly 50% but ROS was increased at a similar level, while the former was restored by treatment with <i>S</i>-nitroso-<i>N</i>-acetyl-penicillamine. …”

Defective cellular signalling in <i>Cdkl5</i> knockout mice. by Elena Amendola (565348)

“…(<b>C</b>) Western blot quantification revealed a significant decrease in phospho-Akt immunoreactivity protein in mutant <i>Cdkl5</i> mice compared with wild-type controls (female: WT, N = 10, HET, N = 6, KO, N = 10; male: WT, N = 5, KO, N = 6; mean ± SEM) (mean ± SEM; *P<0.05, **P<0.01). …”

Discovery of PMSA Derivative <b>11</b> as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis <i>In Vitro</i> and <i>In Vivo</i> by Zhihao Chen (513264)

“…Additionally, <b>11</b> blocked the formation of F-action belts and bone resorption in a concentration-dependent manner. Mechanistically, <b>11</b> decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation from the cytoplasm to nucleus. …”

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

Inhibition of <i>in vitro</i> and <i>in vivo</i> inflammatory responses in rats by p30A peptide. by Jérôme Rambert (46851)

“…(D) Histopathologic analysis confirm p30A ability to decrease all components of AIA lesions: pannus formation and inflammation of the synovium (P), deformity of joint and bones (asterix), bone remodeling and destruction (arrowhead), bone neoformation (arrows) and cartilage destruction.…”

Effects of Cyr61 and Wnt5a on regenerating vasculature and musculature. by Devon C. Snow-Lisy (798898)

“…Scale bar, 50 μm. (Unseeded, MSC and MSC/CD34⁺ HSPC images shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138643#pone.0138643.s001" target="_blank">S1 Fig</a>).…”

Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors by Vincenzo Cantaluppi (92814)

“…In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. …”

The impact of picornaviruses infection on cGAS and STING expression. by Huisheng Liu (408091)

Table_1_Guanidine acetic acid exhibited greater growth performance in younger (13–30 kg) than in older (30–50 kg) lambs under high-concentrate feedlotting pattern.docx by Wen-Juan Li (1444948)

“…In a brief, the results obtained in the present study suggested that GAA (UGAA and CGAA; 1 g/kg DM) could be applied to improve growth performance in younger (13–30 kg) instead of older (30–50 kg) lambs in high-concentrate feedlotting practice.…”

Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish - Fig 2 by Yusuke Nagao (546940)

“…In the <i>sox10a</i>^<i>-/-</i> mutant (K, n = 18), the number is significantly decreased as compared with WT (I). Again, iridoblasts cell counts between the <i>sox10a</i>^<i>-/-</i> mutant and the <i>sox10a</i>^<i>-/-</i><i>;sox5</i>^<i>-/-</i> mutant (L, n = 23) is statistically different (*, <i>p</i><0.05), showing partial rescue in the double homozygote. …”

Dietary or gavaged TU-100 and the ginger component decrease enteropooling stimulated by anti-CD3 antibody treatment in specified pathogen free (SPF) and germ free (GF) C57Bl6 mice. by Nobuhiro Ueno (346397)

Effects of ROCK inhibitors H-1152 and Y-27632 on TNF-induced MLC phosphorylation, actin and CL5 reorganization and the fall in TEER. by Paul R. Clark (714064)

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger - Fig 2 by Andrea Szentesi (3239193)

Analysis of requirement for MYPT1 expression in TNF-induced MLC phosphorylation and leak. by Paul R. Clark (714064)

An mRNA hairpin formed between the <i>sigG</i> leader sequence and RBS significantly decreases P_<i>sigG</i><i>-lacZ</i> translation. by Elizabeth B. Mearls (5150810)

“…<b>(B)</b> Depiction of the <i>sigG</i> RBS-hairpin structure predicted to form in the <i>sigG</i> mRNA leader sequence. The 5’ end of the <i>sigG</i> mRNA (+1), the <i>sigG</i> core RBS, and native GTG (GUG) translation start codon are labeled. …”

Box plot displaying the distributions of the deconvolution derived proportions of cell types. by Arttu Autio-Kimura (20454681)