Combining stabilizing point mutations from different Env variants produces a hyperstable virus, comb-mut. by Daniel P. Leaman (105329)

“…(<b>B</b>) The relative resistance of comb-mut to ligand-induced infectivity decay is shown as a function of the fold decrease in IC50 after 20 hour pre-incubation relative to 1 hour pre-incubation as described in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003184#ppat-1003184-g008" target="_blank"><b>Figure 8</b></a>. …”

28 days of testosterone depletion selectively decrease muscle mass in young mice and have no effect in older mice. by Arik Davidyan (10450896)

Dexmedetomidine (Dex) reversed isoflurane-induced inhibition of Akt activity and decrease of Bcl-xL/Bad ratio in the hippocampus of P7 rats (n = 7 in each group). by Yujuan Li (554062)

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis-0 by Adam I Riker (92580)

“…<p><b>Copyright information:</b></p><p>Taken from "The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis"</p><p>http://www.biomedcentral.com/1755-8794/1/13</p><p>BMC Medical Genomics 2008;1():13-13.…”

Dose-dependent effect of dental materials on hatching rate of zebrafish embryos and larvae at the indicated time points. by Meltem Karahan (19713246)

Loss of Prox1a decreases PR production at 120 hours post-ablation. by Kellie Veen (17343374)

IC₅₀s data of antimalarials against controls. by Winnie Okore (14139712)

The oxygen level (kPa) for 50 and 100% habitat loss for each species and season under a doubling of atmospheric CO₂. by Emily Slesinger (6837740)

Increase in resistance grade is correlated with the loss of <i>in vitro</i> parasite infectivity and decreased cutaneous lesion size. by Jairo E. Perez-Franco (3166050)

DHA decreased cell viability in HepG3 cells. by Arlet Hernandez (12289155)

Gene clustering identifies up- and down-regulated groups that control development, pluripotency, and cell division. by Michael Shelton (382572)

“…<p>Pluripotent H9 hESCs were differentiated for 50 days as previously described [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0222946#pone.0222946.ref012" target="_blank">12</a>], beginning with high (7.5 μM or 10 μM) CHIR99021 concentrations. mRNA samples from the indicated time points were subjected to gene expression profiling. …”

<i>Becn1</i>^FA/FA mutation ameliorates cerebral Aβ accumulation, memory deficits and mortality of Alzheimer’s mouse models. by Altea Rocchi (3278457)

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The <i>Becn1</i> F121A mutation inhibits the BECN1-BCL2 interaction in vivo. by Altea Rocchi (3278457)

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Autophagosomal sequestration of Aβ42 in brain of autophagy-hyperactive mice. by Altea Rocchi (3278457)

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An autophagy-inducing compound ML246 reduces amyloid load in an autophagy-dependent manner in vitro and in vivo. by Altea Rocchi (3278457)

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A <i>Becn1</i> mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease by Altea Rocchi (3278457)

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<i>Becn1</i>^F121A improves the survival rate of PDAPP AD mice. by Altea Rocchi (3278457)

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(a) the wild type with SHV in the left panel and its neighbors in the wild type are shown (b) the S130G mutant in the right panel and its neighbors in the mutant type its neighbors... by Mohd Hassan Baig (441304)

Overexpression of U1 snRNA induces decrease of U1 spliceosome function associated with Alzheimer’s disease by Zhi Cheng (729515)

“…These findings not only helped researchers better understand the functions of U1 snRNA, but also paved the way to reveal the mechanisms of AD from a different point of view and may find a new therapeutic target for the disease.…”

Decreased numbers of motor neurons in Tc1 and Dp(16)1Yey mice. by Sheona Watson-Scales (586942)