Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

The primers related to FAM50A. by Longhai Li (4052044)

“…Knockdown of FAM50A decreased cell proliferation ability, the proportion of EdU positive cells, and the number of CRC cell colonies, whereas overexpressing FAM50A promoted proliferative phenotypes. …”

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

Subjects:

Intake and digestibility during two digestibility trials (1: 20–28 d; 2: 50–56 d) of dairy calves fed different additives in the starter feed (n = 15). by Luisa F. L. Salazar (6664121)

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

Subjects:

Temperature-sensitive germline immortality exhibit decreased histone methylation. by Katherine Kretovich Billmyre (6524396)

Submandibular gland removal decreases avoidance of bitter taste in mice by Masataka Narukawa (20599511)

PRV-induced infertility is caused by decreased P4 level. by Bing-Qian Su (8616981)

Decrease in cleavage score by randomly permuting string-of-beads vaccines. by Emilio Dorigatti (9558024)

“…<p>(a) For each vaccine in the Pareto frontier of each bootstrap, we created 50 new string-of-beads by randomly permuting its epitopes and compared the cleavage scores of the two vaccines. …”

Decreased Incidence of Type 1 Diabetes in Young Finnish Children by Anna Parviainen (9343391)

“…In the middle age group, a significant decrease was observed only among females. …”

mGluR5 receptor decreased glycinergic currents. by Zi-Yang Zhang (4988555)

“…(<b>F</b>) Postsynaptic loading of U-0126 or PD98059 prevented CHPG from decreasing glycinergic responses (U-0126, 107.6 ± 10.4% of baseline at 15–20 min post-CHPG, <i>t</i>[8] = 0.997, <i>p</i> = 0.348; PD98059, 93.1 ± 5.0% of baseline at 15–20 min post-CHPG, <i>t</i>[5] = 0.883, <i>p</i> = 0.418). …”

(a) Mycelial diameter (mm) determination on PDA plates, (b) Inhibition diameters, and (c) inhibition percentages of <i>Aspergillus flavus</i> treated with <i>U. epigea</i> extract... by Martha Cebile Jobe (21175426)

Event-free survival estimate of the pulmonary arterial hypertension cohort based on the HRR1 <18 beats (n = 50) and ≥18 beats (n = 52) after a long follow-up period. by Camila Farnese Rezende (12666902)

miR-275 and miR-305 maternal loss-of-function mutants exhibited impaired flight capability, decreased hatching rate and survival rate. by Junfei Xie (3148638)

Binding of C4BP decreases the association of CEACAM-binding Opa+ <i>N</i>. <i>gonorrhoeae</i> with neutrophils. by Lacie M. Werner (14710419)

The T37A substitution increases both H5N6 M1 protein stability and H5N6 viral replication in mammals. by Chenxi Wang (284364)

Subjects:

PNGaseF-Generated N‑Glycans Adduct onto Peptides in the Gas Phase by Valentina Rangel-Angarita (16972992)

“…To overcome this limitation, we demonstrated that released N-glycans can be removed using a molecular weight cut off filter prior to (glyco)protease digestion, which improves O-glycoproteomic coverage.…”

Analysis of dpMPK-1 spatial expression in N2 <i>C</i>. <i>elegans</i> hermaphrodite germline after chronic exposure to IR at different life-stages. by Elizabeth Dufourcq Sekatcheff (17457627)

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. by Jihoon Jeong (4852690)