Fig 16 - by Deepu Dowarha (5673440)

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Animation displaying S100A1−MDM2 complex generated via the HADDOCK program. by Deepu Dowarha (5673440)

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The p53-Peptide 1 interaction was monitored via fluorescence spectroscopy. by Deepu Dowarha (5673440)

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S100A1 complete sequence indicating highlighted region selected for peptide construction, attaching it to HIV-TAT peptide forming Peptide 1 and its scramble arrangement in Peptide... by Deepu Dowarha (5673440)

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The MCF-7 and/or MDA-MB-468 cells were treated with or without 10 μM Peptide 1 for 48h. by Deepu Dowarha (5673440)

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S100A1 interferes with the p53-MDM2 complex formation. by Deepu Dowarha (5673440)

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S100A1 can interfere with the interaction between p53 and MDM2/MDMX. by Deepu Dowarha (5673440)

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Exploration of the connected interface (S100A1/MDM2) section in S100A1. by Deepu Dowarha (5673440)

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Exploration of the connected interface (S100A1/MDM2) section in MDM2. by Deepu Dowarha (5673440)

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Exploration of the connected interface (S100A1/p53 (1–73)) section in S100A1. by Deepu Dowarha (5673440)

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NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways. by Zhentao Sheng (107495)

“…<p>(A-B) <i>psid-D1</i> (A) or <i>psid-D4</i> (B) clones in 3rd instar fat body, which were marked by GFP expression (pointed by arrowheads), showed decreased MAPK levels (anti-MAPK staining, red). …”

<i>Bbs1</i>^{<i>M390R/M390R</i>} mice have decreased hippocampal proliferation. by Thomas K. Pak (10686881)

“…<p>A.) Normalized initial slope (%) recordings of field excitatory post synaptic potentials (fEPSP) in the hippocampal CA1 Schaffer-collateral pathway between 2 month male control mice (n = 17, 4 mice) and <i>Bbs1</i>^{<i>M390R/M390R</i>} mice (n = 16, 4 mice). …”

Decreased glycosylated α-DG and laminin levels distal to the glial dome in <i>Large</i>^{<i>myd/myd</i>} mice. by Shigefumi Morioka (8893511)

DataSheet_1_Circulating exosomes decrease in size and increase in number between birth and age 7: relations to fetal growth and liver fat.pdf by Marta Díaz (337207)

“…</p>Conclusion<p>Early-life changes in circulating exosomes include a minor decrease in size and a major increase in number, and these changes may be influenced by fetal growth. …”

Orsay virus infection of the <i>lin-8(n2731</i>) synMuv A mutant induces a Muv phenotype indicative of decreased synMuv B gene activity, and 2 different synMuv B mutants produce 50–100× less Orsay virus RNA. by Ashwin Seetharaman (615458)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

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Foldases and holdases each decrease the level of unfolded protein. by Adam MR de Graff (9767829)

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…The most active compound is 3-benzoylamino<i>-N</i>-(2-ethyl-phenyl)-benzamide or <b>F3</b>, blocking TASK-1 with an IC₅₀ of 148 nM, showing a reduced inhibition of TASK-3 channels and not a significant effect on different K⁺ channels. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…The most active compound is 3-benzoylamino<i>-N</i>-(2-ethyl-phenyl)-benzamide or <b>F3</b>, blocking TASK-1 with an IC₅₀ of 148 nM, showing a reduced inhibition of TASK-3 channels and not a significant effect on different K⁺ channels. …”