Highly Efficient Singlet Oxygen Generation by BODIPY–Ruthenium(II) Complexes for Promoting Neurite Outgrowth and Suppressing Tau Protein Aggregation by Cheng-Yun Wu (9428029)

Silencing class II PI3Ks decreases autophagy in both control and <i>Vps34</i> null MEFs. by Kelly Devereaux (466106)

Over-expression of DN VPS4 in HEK293T cells leads to increased extracellular α-synuclein and parallel decrease in lysosome. by Takafumi Hasegawa (18204)

“…Treatment with lysosomal inhibitor bafilomycin A1 (0–10 nM) for 24 hours induced the buildup of cellular αSYN oligomers (<i>asterisk</i>) in parallel with the increase of extracellular αSYN monomer (<i>closed triangle</i>). …”

Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α_1A-Adrenoceptor Antagonists by Fei Zhao (183673)

“…In this study, two highly selective and potent α_1A-AR antagonists, compounds (<i>R</i>)-<b>14r</b> (IC₅₀ = 2.7 nM, α_1B/α_1A = 640.1, α_1D/α_1A = 408.2) and (<i>R</i>)-<b>23l</b> (IC₅₀ = 1.9 nM, α_1B/α_1A = 1506, α_1D/α_1A = 249.6), which exhibited similar activities and better selectivities in cell-based calcium assays as compared with the marketed drug silodosin (IC₅₀ = 1.9 nM, α_1B/α_1A = 285.9, α_1D/α_1A = 14.4), were identified. …”

Effects of High-Intensity Interval Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ul... by Othmar Moser (789838)

“…Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. …”

The percent of students who, if a science instructor were to tell a joke about a specific subject, might find the joke funny and might find the joke offensive. by Katelyn M. Cooper (5634851)

IC₅₀ of indole alkaloid against lipase [23]. by Atikarn Janthongkaw (17020498)

SS-31 treatment reduced ox-LDL-induced lipid accumulation in peritoneal derived macrophages, associated with decreased lipid influx. by Meng Zhang (154027)

NS co-suppresses Ox-LDL-induced apoptosis in RAW264.7 cells. by Yihua Wang (491766)

Interference with the <i>kgb-1</i> MAPK pathway decreases oxidative stress sensitivity in <i>ttr-33</i> mutants. by Sarah-Lena Offenburger (669498)

Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia by Mary E. Irwin (293687)

“…In two human Ph+ALL cell lines, inhibition of ErbB kinase activity with canertinib resulted in a dose-dependent decrease in the phosphorylation of an ErbB kinase signaling target p70S6-kinase T389 (by 60% in Z119 and 39% in Z181 cells at 3 µM). …”

Treatment of cancer cells with FL118 significantly decreases BrdU positive cells (proliferative cells) and induces apoptotic markers. by Xiang Ling (307318)

NS delays the formation of atherosclerotic plaques in ApoE^-/- mouse models. by Yihua Wang (491766)

Decreased Connexin 40 expression in CHAPb Tg left atrium at 6 months of age leads to atrio-ventricular conduction delay. by Willemijn van Eldik (4662955)

MBIC50 and MBEC50 values (µg/mL) of synthesized 1,2,3,5-tetrazine derivatives against bacteria pathogen strains. by Jean Paul Dzoyem (6424445)

Subjects:

Necdin deficiency decreases <i>p16</i> expression and increases <i>Cdk1</i> expression in the embryonic neocortex. by Ryohei Minamide (505053)

Silencing of SphK1, but not SphK2, decreases HPAEC migration by S1P in wound healing ECIS assay. by Evgeny V. Berdyshev (307465)

Inhibition of PI3K activity decreases uptake of Opa_CEA-expressing gonococci via CEACAM1. by Maike Voges (154488)

Necdin deficiency decreases <i>p16</i> expression and increases <i>Cdk1</i> expression in primary NPCs. by Ryohei Minamide (505053)

IODVA1 inhibits lamellipodia and circular dorsal ruffle (CDR) formation in MDA-MB-231 cells and decreases Rac activation. by Anjelika Gasilina (8566296)