Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Hepatitis C virus (HCV) is a human pathogen with high morbidity. The HCV NS3/4A protease is essential for viral replication and is one of the top three drug targets. …”

Rapamycin decreases Schwann cell markers, whereas statin induces Schwann cell markers. by Andrea Preitschopf (629851)

Decreased sensitivity of coculture HIV spread to RAL predicts multiple infections per cell. by Mikaël Boullé (3329427)

“…Blue dashed line represents parametrization of the cell-free infection response to RAL in terms of IC₅₀ (1.9 nM) and hill coefficient (0.7). Red dashed line represents the fit of coculture infection using the decreased sensitivity to RAL (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005964#sec008" target="_blank">Materials and methods</a>). …”

Sildenafil treatment during recovery does not affect hyperoxia-induced decreases in alveolar counts. by Marta Perez (526067)

Good things come to those who wait—Decreasing impatience for health gains and losses by Stefan A. Lipman (4724040)

UNC-62 RNAi decreases expression of collagen genes and increases expression of intestinal genes. by Eric L. Van Nostrand (30730)

“…For 1699 genes with intestine-enriched expression <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-McGhee1" target="_blank">[23]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Pauli1" target="_blank">[33]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Spencer1" target="_blank">[34]</a> as well as the subset of 291 genes that also decrease expression with age <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003325#pgen.1003325-Budovskaya1" target="_blank">[10]</a>, we determined the average mean-centered fold-change from triplicate RNA-seq experiments of <i>unc-62</i> RNAi as compared to controls. …”

Lipolytic treatment decreased cellular neutral lipids and increased extracellular fatty acids and glycerol. by Caroline Louis (332423)

The number of plasmacytoid dendritic cells (pDCs) decreased after anti-CXCR3 treatment and <i>T</i>. <i>cruzi</i> infection. by Camila Pontes Ferreira (6194006)

EC50 and percentage decrease in intracellular <i>Listeria</i> viability for effective compounds. by Marie-Eve Charbonneau (5658799)

Fitting curve of rock E₅₀. by Junxia Zhou (14381598)

GSH depletion leads to a strong decrease in SCF-dependent HIF-1α PHD activity in LAD2 cells. by Bernhard F. Gibbs (328262)

Ear stimulation targets used of taVNS or staVNS. by Duyan Geng (12072181)

CHO cell line stably transfected to synthesize rhTSG-6 forms aggregates resulting in a decrease of protein production. by Dong-Ki Kim (847216)

Kinematic analyses including finite helical axes of drop jump landings demonstrate decreased knee control long after anterior cruciate ligament injury - Fig 4 by Helena Grip (7610468)

Increase in the amount of AGEs in the silkworm hemolymph after ingestion of a high glucose diet and decrease in AGEs after injection of aminoguanidine. by Yasuhiko Matsumoto (206628)

Fig 4 - by Duyan Geng (12072181)

Fig 6 - by Duyan Geng (12072181)

Fig 5 - by Duyan Geng (12072181)

PAD4-deficient mice display a slight decrease in weight loss upon influenza infection but similar survival kinetics. by Saskia Hemmers (214438)

AAV-mediated Atp6v1c1 knockdown decreased TRAP positive cells and Atp6v1c1 expression in the periodontitis lesion area. by Sheng Li (107261)