Showing 17,121 - 17,140 results of 44,775 for search '(( 50 ((ns decrease) OR (a decrease)) ) OR ( 5 ((ng decrease) OR (mean decrease)) ))', query time: 1.04s Refine Results
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    Data_Sheet_1_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

    Published 2021
    “…To understand the molecular reasoning behind the unavailability of such mutation in real life, we have used circular dichroism (CD) spectroscopy, differential scanning calorimetry (DSC), molecular dynamics (MD) simulation, and stability-based enzyme activity to compare the stability and dynamic behaviors of native and S130G/A mutant form of BlaC. A significant decrease in melting temperature (BlaC T<sub>M</sub> 60°C, S130A T<sub>M</sub> 50°C, and S130G T<sub>M</sub> 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”
  10. 17130

    Data_Sheet_2_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

    Published 2021
    “…To understand the molecular reasoning behind the unavailability of such mutation in real life, we have used circular dichroism (CD) spectroscopy, differential scanning calorimetry (DSC), molecular dynamics (MD) simulation, and stability-based enzyme activity to compare the stability and dynamic behaviors of native and S130G/A mutant form of BlaC. A significant decrease in melting temperature (BlaC T<sub>M</sub> 60°C, S130A T<sub>M</sub> 50°C, and S130G T<sub>M</sub> 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”
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    Evaluation of whole wheat flour sourdough as a promising ingredient in short dough biscuits by Tuba ALIOĞLU (10464668)

    Published 2021
    “…The incorporation of WWF on dough formulation increased both G' and G” moduli, while the inclusion of WWF by sourdough fermentation caused a significant reduction. Spread ratio of the biscuits decreased as the WWF ratio in the formulation increased (p < 0.05). …”
  15. 17135

    Vps34 supports Treg maintenance in lymphoid and non-lymphoid tissues. by Erienne G. Norton (9612079)

    Published 2025
    “…GSEA enrichment plots showing increased cTreg signature (left; i.e., top 200 upregulated genes [log<sub>2</sub>FC > 0.5, FDR < 0.05] in cTregs versus eTregs) and decreased eTreg signature (right; i.e., top 200 upregulated genes [log<sub>2</sub>FC > 0.5, FDR < 0.05] in eTregs versus cTregs) in CD45.2<sup>+</sup> Tregs from <i>Foxp3</i><sup>Cre</sup><i>Pik3c3</i><sup>fl/fl</sup> mixed BM chimera mice compared to control mixed BM chimera mice. …”
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