Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 4_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Overlayed expression profiles of cyclins A2 and B1. by James W. Jacobberger (184625)

PSD curves of cells at different densities. by Mingkun Pang (11873753)

Repeated injection of GdCl₃ attenuates <i>S</i>. <i>japonicum</i> egg-induced hepatic granuloma inflammation. by Shengsheng Zheng (789770)

Effect of U0126 pre-treatment of HTR-8/SVneo cells on invasion in presence or absence of EGF. by Ankita Malik (1863829)

Effect of STAT3 and STAT1 silencing on invasion in presence or absence of EGF. by Ankita Malik (1863829)

Repeated injection of GdCl₃ reduced egg-induced hepatic fibrogenesis. by Shengsheng Zheng (789770)

Effect of GdCl₃ treatment on expression of IL-13Rα2 and CD68 in egg-induced hepatic granuloma. by Shengsheng Zheng (789770)

Ca²⁺ supplementation <i>in vitro</i> affects the expression of macrophage polarization markers. by Yusuf Cem Eskiocak (10789281)

CHC amounts at the wing cuticle surface depend on Osy function. by Yiwen Wang (666361)

Ca²⁺ supplementation <i>in vitro</i> increases cell death in polarized human macrophages and favours an M1 phenotype. by Yusuf Cem Eskiocak (10789281)

Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…Notably, among these derivatives, compound <b>15</b> showed improved anti-HAdV activity (IC₅₀ = 0.27 μM), significantly decreased cytotoxicity (CC₅₀ = 156.8 μM), and low <i>in vivo</i> toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosamide, supporting its further <i>in vivo</i> efficacy studies for the treatment of HAdV infections.…”

Purine Metabolism changes in response to liver irradiation. by Irwin Jack Kurland (749962)

CREB Targets Define the Gene Expression Signature of Malignancies Having Reduced Levels of the Tumor Suppressor Tristetraprolin by Mohammad Fallahi (200679)

“…These analyses defined a signature of 50 genes differentially regulated between high and low <i>TTP</i>-expressing tumors. …”

Unclustered ephrin-A5-Fc and EphA4-Fc partially reduce astrocytic gliosis. by Yona Goldshmit (205708)

Passenger mutations accurately classify human tumors by Marina Salvadores (6589187)

“…In particular, introducing the RMD features into a combined classification model increased the fraction of diagnosed patients by 50 percentage points (at 20% FDR). …”

The Association of Geographic Coordinates with Mortality in People with Lower and Higher Education and with Mortality Inequalities in Spain by Enrique Regidor (636687)

“…</p><p>Methods</p><p>Data are from a nation-wide prospective study covering all persons living in Spain's 50 provinces in 2001. …”

Comparison of TPH2 expression in the ventral tegmental area and raphe. by Motoki Imai (7324697)

A. Quality of evidence: TOTVA vs. COT. B. Quality of evidence: TOTVA vs. NTET (including robotic approaches). by Huixia Ren (500186)