Bar graphs showing the total loss rates and 95% confidence intervals for each region in Ethiopia, Kenya, and Benin. by Beatrice T. Nganso (4114768)

RhoA staining of SH-SY5Y neurons transfected with non-targeted ChABC or GFP and plated onto CSA. by Priscilla Day (4582720)

Multinomial logistic regression analyses predicting impact on vaccination intention by demographics (more likely vs. less likely to get vaccinated comparison). by Rikki H. Sargent (12441964)

Loss of nsp14-ExoN alters recombination at multiple genomic loci and skews recombined RNA populations. by Jennifer Gribble (10005444)

“…<p>Mean recombination frequency at each position across the MHV genome was compared in MHV-WT (blue) and MHV-ExoN(-) (orange) infected monolayer (A) and viral supernatant RNA (B). 2-way ANOVA with multiple comparisons (N = 3). …”

Image_5_Identification of COP9 Signalosome Subunit Genes in Bactrocera dorsalis and Functional Analysis of csn3 in Female Fecundity.JPEG by Jing Zhang (23775)

“…The expression level of EcRB1 and USP, which encode the heterodimer receptors of 20E, and vitellogenin transcripts (Vg1 and Vg2) was suppressed in the fat body of female adults injected with csn3dsRNA. Decreased level of Vg1 protein was confirmed by means of Western blots. …”

ACE2 human variants that affect ACE2/SARS-CoV-2 S protein complex interaction energy for 6m0j. by Javier Delgado Blanco (9740245)

Longitudinal lung function readouts. by Zahra Khalajzeyqami (6865475)

BAL cells count at different time-points. by Zahra Khalajzeyqami (6865475)

Longitudinal micro-CT assessment. by Zahra Khalajzeyqami (6865475)

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Effects of ischemia and <i>low pH plus G6P</i> treatments on mPTP opening under de-energized conditions. by Gonçalo C. Pereira (9022700)

Mass Spectrometry Experiment 2 and 3: Comparison of Vpu WT and mutants. by Charlotte A. Stoneham (10819125)

Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

“…Coadministration of itraconazole increased the AUC_0-inf of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”

Tat enhances vIL-6-induced angiogenesis and tumorigenesis through inactivation of PTEN and GSK-3β signals in CAM model. by Feng Zhou (76988)

“…The quantification of blood vessels was expressed as the mean ± SD (n = 5 to 8). (<b>E</b>) Overexpression of GSK-3β decreased the promoted effect of Tat on vIL-6-mediated tumorigenesis. 4E3 cells were treated as in (D). …”

Tubulin modifications and gamma-tubulin distribution in the tegument. by Inés Guarnaschelli (18102211)

Image 1_A comprehensive immune repertoire signature distinguishes pulmonary infiltration in SARS-CoV-2 Omicron variant infection.jpeg by Xuechuan Li (14430114)

“…</p>Results<p>Patients with pulmonary infiltration exhibit lymphopenia, a decreased proportion of the overall TCR repertoire alongside an increased BCR repertoire, reduced IGHD and IGHM isotype expression, a shorter mean CDR3 length for TRG, and a longer mean length for TRD, as well as diminished clonality and diversity in the TCR/BCR repertoire. …”

Effects of conivaptan on brain water content (BWC), blood-brain-barrier (BBB) disruption, plasma and urine sodium and osmolality. by Emil Zeynalov (596088)

“…Following MCAO, Evans Blue (EB) extravasation index (I/C) was increased in vehicle treated mice, and reduced in conivaptan treated mice, naïve, n = 5, vehicle, n = 8, Conivaptan 0.2 mg, n = 8. (C, D) Conivaptan treatment of 0.2 mg resulted in an elevation of plasma sodium and osmolality, and decreased urine sodium and osmolality due to aquaresis. …”

Changes to distal lung structure of both α7 genotypes with and without CS exposure. by Lorise C. Gahring (271630)

“…In these representative sections the arrows point to AMs and in the α7^E260A:G arrow heads identify regions of increased cellularity that produce alveolar sacs of decreased size. …”

Expression levels of <i>Alox15</i>, <i>Hmox1</i> and <i>Fth1</i> in pulmonary myeloid cell populations. by Emilie Pollenus (10147748)