Depletion of RipA results in a reversible arrest in growth of <i>M. smegmatis.</i> by Erik C. Hett (244859)

“…OriE: <i>E. coli</i> origin of replication. (B) <i>ripA</i> depletion strain of <i>M. smegmatis</i> was grown with inducer (Tet), then inoculated into media with decreasing amounts of inducer and followed by OD₆₀₀ over time. …”

Maternal kidney changes due to STZ administration and pregnancy. by Narumi Takahashi (5343218)

Dynamic binding of patient serum antibody isotypes over short to medium term for moderate and mild COVID-19 disease. by Marie Le Berre (6299012)

Table_1_The association between genetic variants at 3’-UTR and 5’-URR of HLA-G gene and the clinical outcomes of patients with leukemia receiving hematopoietic stem cell transplant... by Ding-Ping Chen (164867)

“…HLA-G gene plays an important role in immune tolerance, assisting immune escape of tumor cells, and decrease of transplant rejection. In this study, we explored the association of genetic variants at the 3’-untranslated region (3’-UTR) and 5’-upstream regulatory region (5’-URR) of HLA-G gene with the adverse outcomes of patients with leukemia receiving HSCT. …”

DataSheet_1_Intranasal inoculation of IFN-λ resolves SARS-CoV-2 lung infection via the rapid reduction of viral burden and improvement of tissue damage.doc by Haeun Shin (11932134)

“…Introduction<p>The innate immune responses of upper airway could further our understanding toward antiviral strategies against SARS-CoV-2. We characterize the potential of interferon (IFN)-λ as an innate immune inducer for the rapid clearance of SARS-CoV-2 in the lung and the therapeutic efficacy of intranasal inoculation of IFN-λ to resolve acute lung infection.…”

Image_1_Thyroxine Induces Acute Relaxation of Rat Skeletal Muscle Arteries via Integrin αvβ3, ERK1/2 and Integrin-Linked Kinase.pdf by Ekaterina K. Selivanova (11430214)

“…The effect of T4 on α₁-adrenergic contraction is stronger compared to T3 and involves the suppression of extracellular matrix signaling via integrin αvβ3, ERK1/2 and ILK with subsequent decrease of MLC2 (Ser19) phosphorylation.…”

Healthy control group HR and CBF changes. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

List of abbreviations used in this paper. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

Estimation of the CO and CBF. by Liuchuang Wei (19273099)

“…Computational results revealed that hypovolemia reduces cerebral blood flow by approximately 100 mL/min due to a 30% decrease in blood volume, while vascular dysfunction—marked by a 50–100% increase in arterial stiffness—further diminishes cardiac output and cerebral perfusion. …”

DOT or SAT for Rifampicin-resistant tuberculosis? A non-randomized comparison in a high HIV-prevalence setting by Erika Mohr (3331566)

“…<div><p>Background</p><p>Daily directly-observed therapy (DOT) is recommended for rifampicin-resistant tuberculosis (RR-TB) patients throughout treatment. We assessed the impact of self-administered treatment (SAT) in a South African township with high rates of RR-TB and HIV.…”

GSTM3 A/B Polymorphism and Risk for Head and Neck Cancer: A Meta-Analysis by Yu Xu (52257)

“…Stratification by tumor site indicated that the GSTM3 polymorphism was associated with a decreased risk of laryngeal cancer under recessive model and homozygote comparison (OR = 0.52, 95%CI: 0.30–0.89; and OR = 0.50, 95%CI: 0.29–0.87, respectively); By stratifying source of control, decreased cancer risk was observed in hospital-based population under all genetic models (OR = 0.67, 95%CI: 0.56–0.81 for the dominant model; OR = 0.66, 95%CI: 0.46–0.95 for the recessive model; OR = 0.55, 95%CI: 0.37–0.83 for the homozygote comparison model, and OR = 0.70, 95%CI: 0.58–0.84 for the heterozygote comparison model).…”

Image3_miR-146a is a critical target associated with multiple biological pathways of skin aging.jpg by Klodjan Stafa (154945)

“…Effects on markers of skin aging, including cell proliferation, production of Collagen-1 and inflammatory cytokines were assessed.</p><p>Results: We show that the expression of miR-146a decreases with age in dermal fibroblasts and inhibition of miR-146a in 19y and 62y old NHDFs induced significant changes in essential clock genes indicating an association with circadian rhythm control. …”

Image1_miR-146a is a critical target associated with multiple biological pathways of skin aging.jpg by Klodjan Stafa (154945)

“…Effects on markers of skin aging, including cell proliferation, production of Collagen-1 and inflammatory cytokines were assessed.</p><p>Results: We show that the expression of miR-146a decreases with age in dermal fibroblasts and inhibition of miR-146a in 19y and 62y old NHDFs induced significant changes in essential clock genes indicating an association with circadian rhythm control. …”

Image2_miR-146a is a critical target associated with multiple biological pathways of skin aging.jpg by Klodjan Stafa (154945)

“…Effects on markers of skin aging, including cell proliferation, production of Collagen-1 and inflammatory cytokines were assessed.</p><p>Results: We show that the expression of miR-146a decreases with age in dermal fibroblasts and inhibition of miR-146a in 19y and 62y old NHDFs induced significant changes in essential clock genes indicating an association with circadian rhythm control. …”

table_5_B Cell-Related Circulating MicroRNAs With the Potential Value of Biomarkers in the Differential Diagnosis, and Distinguishment Between the Disease Activity and Lupus Nephri... by Huidi Zhang (716813)

“…We then investigated the relationship between expressions of the selected miRNAs and SLE clinical indicators. As a result, 14 miRNAs (miR-103, miR-150, miR-20a, miR-223, miR-27a, miR-15b, miR-16, miR-181a, miR-19b, miR-22, miR-23a, miR-25, miR-92a, and miR-93) were significantly decreased in the plasma of SLE patients compared with healthy controls (P < 0.05) and could act as the diagnostic signature to distinguish SLE patients from healthy donors. …”

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing <i>Iso</i>combretastatins and Phenstatins as Antitumor Agents by Yanqing Pang (4386715)

“…Most of these selenium containing hybrids exhibited potent cytotoxicity against a panel of cancel cell lines, with IC₅₀ values in the submicromolar concentration range. …”

<i>PsnWRKY95</i> transgenic plants selection and functional analysis of <i>PsnWRKY95</i> in cadmium resistance. by Yuzhao Ma (12840632)

Demonstration that SP-1 and SP-3 negatively regulates the PP2A-Aα promoter. by He-Ge Chen (90952)

“…Expression of the exogenous pCMV-SP-1 in both types of ocular cells attenuated expression of the endogenous gene coding for PP2A-Aα. F. Expression of the exogenous SP-3 in both types of ocular cells induced only slight decrease in the luciferase reporter gene activity within 0 to 500 ng of the pCMV-SP-3 plasmid, which is not statistically significant. …”

Monobenzyltin Complex C1 Induces Apoptosis in MCF-7 Breast Cancer Cells through the Intrinsic Signaling Pathway and through the Targeting of MCF-7-Derived Breast Cancer Stem Cells... by Somayeh Fani (2967933)

“…<p><b>(A, B) Quantitative study of gene expression, (C) western blot analysis of protein markers of the apoptosis pathway in MCF-7 treated cells with a concentration of 2.5 μg/mL (IC</b>_<b>50</b><b>) respectively</b>. …”

Data_Sheet_1_Expression of Drosophila Matrix Metalloproteinases in Cultured Cell Lines Alters Neural and Glial Cell Morphology.PDF by Scoty Hearst (10792686)

“…Inhibition of endogenous MMPs decreased neurite formation, length and βIII Tubulin protein levels in differentiated SH-SY5Y cells. …”