ICOS KO and ICOS YF mice have distinct Treg defects in the brain during chronic <i>T</i>. <i>gondii</i> infection. by Carleigh A. O’Brien (8357064)

“…<b>(E)</b> Treg number in the brains of WT, ICOS KO, and ICOS YF mice (n = 3–5 per group, data is pooled from three independent experiments and analyzed by randomized block ANOVA). …”

PNNs (<i>WFA</i>) were removed by ChABC microinjection into mPFC. by Wen Chen (30046)

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma by Marzena Mazur (4761027)

“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC₅₀ values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”

NBQX increased PNNs (<i>WFA</i>), tenascin-R, aggrecan and Neurocan in the medial prefrontal cortex in PTZ-treated rats. by Wen Chen (30046)

Chronic PTZ treatment reduced PNNs (<i>WFA</i>), tenascin-R, aggrecan and Neurocan in the medial prefrontal cortex. by Wen Chen (30046)

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... by Salma, Younes

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K_v4 is Required for Maintaining Excitability in <i>Drosophila</i> Neurons. by Yong Ping (233004)

“…<p><i>A</i>, Representative firing patterns recorded with current injections of 40, 60, and 100 pA from wild-type (wt) and DNK_v4 (DN) neurons. With increasing current injections, wt neurons display a reduction in the delay to the first AP and an augmentation in AP firing frequency, maintaining excitability for the duration of the 500 ms stimulus. …”

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo by Azariyas A. Challa (143195)

“…In mice, administration of 4 mg/kg WF-A daily for 2 weeks reduced isoproterenol-induced myocardial fibrosis by 50%. …”

Mean (top panel) and percentile rank (bottom panel) regression estimates of brain tissue volume across age in the AD sample (n=219). by David Alexander Dickie (499804)

“…<p>The slopes of these lines represent the beta coefficients in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084093#pone-0084093-t005" target="_blank">table 5</a>. The mean-based model expects all percentile ranks to change at the same rate, i.e. be parallel. …”

Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov... by Salma, Younes

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h-S100A7-mediated promotion of α-secretase activity and sAPPα secretion and decreased amyloid-beta_1–42 level are prevented by p42/44MAPK and PKC signal-transduction inhi... by Weiping Qin (585156)

Density plot with counts, representing birth dates estimated for calves sampled with their mothers during January 2019 and February 2018. by Michelle Gelippi (9580022)

Protein and mRNA expression of Glo-I in pHEP, pHSC and pLSEC in controls, early and advanced cirrhosis. by Marcus Hollenbach (376231)

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation by Nabil G. Seidah (148050)

“…Western blotting and immunohistochemistry of <em>AnxA2^−/−</em> tissues revealed that the LDLR was decreased by ∼50% in extrahepatic tissues, such as adrenals and colon. …”

<i>C</i>. <i>auris</i> uses a unique cell wall mannan layer to evade IL-1R signaling mediated host defense. by Abishek Balakumar (20189865)

S2 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

S1 File - by Yosuke Kameno (342665)

“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”

Histological analyses performed using KB, CaBP, and SMI-32 staining in sections of the hippocampus. by Shigeyoshi Saito (208866)

DAT and NAT activity and the effects of MPP(+) on mitochondrial activity in SH-SY5Y cells. by Joanna A. Korecka (415952)

“…Mitochondrial intensity is significantly increased in RA treated SH-SY5Y cells treated with 0.01 mM MPP(+) up to 0.05 mM, and significantly decreased in cells treated with 0.1 mM, 0.05 mM and 1 mM MPP(+). …”

Expression of LvrAB requires at least one functional PerR homolog but the absence of LvrAB alone is not solely responsible for avirulence of the <i>perRA/B</i> double mutant. by André A. Grassmann (11141592)