Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Heparanase activity in murine (A) and human (B) sepsis. by Lukas Martin (747245)

Heparanase level in murine (A) and human (B) sepsis. by Lukas Martin (747245)

Visualization of the baseline (WT) and <i>Tsc1</i> null (KO) results within a smooth muscle cell phenotypic space bounded by vertices defined as purely contractile (1.0), purely sy... by Ana C. Estrada (8917370)

miR-204-5p inhibits glioma cell growth <i>in vitro</i>. by Zhiqiang Xia (764303)

“…D, <i>In vitro</i> proliferative ability of glioma cells was significantly decreased in overexpressed miR-204-5p cells compared with LEV cells by colony formation assay. …”

KS1 and KS2 combined RNA-seq experiment differentially expressed genes: <i>Kmt2d</i>^<i>-/-</i> vs <i>Kmt2d</i>^<i>+/+</i>, Day 7. by Christine W. Gao (18794576)

Time-dependent decrease of the water content as a function of the polyethylene glycol (PEG) concentrations (2a, top) and correlation between polyethylene glycol (PEG) concentration... by Niels Hammer (616269)

“…<p>Applying the osmotic stress technique to iliotibial tract specimens caused a PEG- dependent decrease of their water content. PEG concentrations of 2.5 wt% (grey arrow) were most suitable for osmotically adjusting the water content of iliotibial tract samples and their corresponding acellular scaffolds.…”

Developmental toxicity induced by 2 μg/ml propofol. by Yali Ge (417371)

Datasheet1_Mean arterial pressure trajectory with premature cardiovascular disease and all-cause mortality in young adults: the Kailuan prospective cohort study.pdf by Zongshuang Song (16975854)

“…Each of the trajectories was labelled as low-stable, middle-stable, decreasing, increasing, or high-stable. With the low-stable trajectory group as the reference, the multivariate adjusted HR (95%CI) of CVD for the middle-stable, decreasing, increasing and high-stable groups were 2.49 (1.41–4.40), 5.18 (2.66–10.06), 5.91 (2.96–11.80) and 12.68 (6.30–25.51), respectively. …”

Podocyte VEGF knockdown downregulates endothelial alpha_Vbeta3 integrin. by Delma Veron (151378)

“…<p>(A) Representative immunoblots show decreased alpha_Vbeta₃ integrin in VEGF knockdown kidney lysate, while beta₁ integrin and S⁷⁸⁵- beta₁ integrin (P-β1) remain at control levels. …”

Binding level of HNF-5 to AGT promoter sequences is reduced by mutation in its binding sites. by Juan Wang (115708)

“…Compared with the group with intact human AGT_-4,358/+122, the binding level of HNF-5 protein to human AGT_-4,358/+122 significantly decreased in HK-2 cells with HNF-5 binding sites mutation. …”

Stress and Sucrose Intake Modulate Neuronal Activity in the Anterior Hypothalamic Area in Rats - Fig 5 by Arojit Mitra (3165708)

5-HT-induced cardiomyocyte injury required the presence GC or NE <i>in vitro</i>. by Wang Xinxing (523139)

“…</b> The cell viability of cardiomyocytes treated with 10⁻⁸ M 5-HT and 10⁻⁶ M GC decreased significantly compared with the control. …”

Impact of age on sharing of top 5000 TCRβ clones. by Sarah A. Johnson (11355817)

MiR-29b-2-5p favors <i>Shigella</i> binding and intracellular replication. by Ushasree Sunkavalli (3916721)

“…<i>Shigella</i> infection was performed at MOI 10, except for the binding experiments (panels D and E) in which MOI 50 was used. Results are shown as mean ± s.e.m. from 4 (panel F), 5 (panels C and E) or 15 (panel G) independent experiments; *P<0.05, ***P<0.001.…”