Activation of deep SC neurons recapitulates delayed LER in <i>Setd5</i>^<i>+/−</i> animals. by Laura E. Burnett (18794525)

“…(<b>I</b>) Proportion of trials at different laser intensities that either show an increase (white), decrease (black), or no change (grey) in speed upon light activation for <i>Setd5</i>^+/+ (top) and <i>Setd5</i>^+/<i>−</i> (bottom). 0.01 mW mm⁻²: 35 trials, <i>p</i> = 0.649; 0.5 mW mm⁻²: 111 trials, <i>p</i> = 0.193; 5 mW mm⁻²: 50 trials, <i>p</i> < 0.001; 10 mW mm⁻²: 49 trials, <i>p</i> < 0.001; 15 mW mm⁻²: 61 trials, <i>p</i> = 0.004; 20 mW mm⁻²: 49 trials, <i>p</i> < 0.001, X² test of independence. …”

Image 5_Lyg1 deficiency aggravated LPS-induced chronic epididymal inflammation and sperm dysfunction in mouse.jpeg by XueXia Liu (13114949)

Simulation fitting COVID-19 data from Italy. by Fernando Córdova-Lepe (9727230)

Effect of obesity on angiotensin II receptors protein expression in mesenteric arteries. by Graziela N. Hagihara (623403)

Directed evolution of HIV-1 to utilize CD4^low target cells. by David Beauparlant (3491435)

“…<b>(E)</b> Adaptation to CD4^low target cells results in high resistance to CD4 inhibitor compared to wild type HIV-1 isolates. Comparison of IC50 of CD4-blocking DARPin 55.2 against 41 wild-type HIV-1 strains from different clades (black dots, see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006255#ppat.1006255.s003" target="_blank">S3 Table</a> for details on virus panel and individual IC50 values) and the CD4^low adaptation virus panel (colored dots, see legend) probed by Env pseudovirus infection on TZM-bl cells. …”

HCV elicits differential expression of circRNAs. by Tzu-Chun Chen (787255)

Blockade of IFN<i>γ</i> production rescues the T_reg cell homeostatic defect and alleviates systemic autoimmunity in <i>Foxp3</i>^<i>Cre</i><i>miR-142</i><sup><... by Wei-Le Wang (133402)

Secondary attack rates among 1407 close contacts based on case-patient^a characteristics, their own characteristics, and exposure setting. by Joseph Walker (4341838)

Dendritic length of Golgi Cox-impregnated layer V pyramidal neurons in the peri-infarct cortex and in the corresponding contralateral cortex. by Katrin Frauenknecht (305672)

Cathepsin B is the main cathepsin involved in the ouabain-induced reduction in PrP^C levels. by Mohadeseh Mehrabian (455336)

Dysregulated alternative splicing in DM1 hiNeurons at 10 DPI. by Mougina K. Eltahir (12988153)

“…(d) Scatter plots pertaining to Fig 5c show decreased inclusion of <i>MAPT</i> e2 (top), <i>CSNK1D</i> e9 (bottom left) and <i>MPRIP</i> e9 (bottom right) in DM1 hiNeurons. …”

A deficiency of TLR9 decreases chronic stress-induced changes of pro-inflammatory cytokine levels by macrophages TLR9 knockout mice or wild type BALB/c mice aged 6 to 8 weeks were... by Yanxiao Xiang (468904)

Efficacy of R-LM113 and R-115 administered early after tumor implantation on the growth of HER2-LLC1 tumors. by Valerio Leoni (440542)

“…The mice decreased in number because of deaths caused by the primary tumor. …”

Mendelian randomization results with COVID-19. by Alish B. Palmos (5857379)

Schematic diagram of STTFP model. by Guozhu Sui (21672798)

Effect of obesity on contraction of mesenteric arteries to angiotensin II and norepinephrine. by Graziela N. Hagihara (623403)

Contribution of angiotensin II receptors activation to the vascular effects of angiotensin. by Graziela N. Hagihara (623403)

Effect of angiotensin II on eNOS phosphorylation in mesenteric arteries. by Graziela N. Hagihara (623403)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”