Image4_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Image2_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

DataSheet1_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Social Determinants of the Lung Cancer Care Continuum by Cherie P Erkmen (11576761)

“…For example, smoking increases the risk of getting lung cancer by 10x, and those in lower income brackets and of lower education level are 2 to 3 times more likely to be smokers.2,3 Though annual lung cancer screening can decrease mortality4, minority and underserved populations are less likely to participate in screening and less likely to follow-up after a baseline scan.5-7 Low participation and compliance with lung cancer screening creates a missed opportunity to reduce mortality among these populations, thus exacerbating lung cancer disparity.7 Even when diagnosed, African Americans and those in the lowest socioeconomic quartile have significantly lower survival from lung cancer compared to others.8,9 This work details how disparities along the continuum of lung cancer care result in higher and morbidity.…”

Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Clinical and Hypoxemic Childhood Pneumonia over Three Years in Central Malawi: An Observational Study by Eric D. McCollum (252799)

“…At 76% three-dose PCV13 coverage, versus 0%, the time-series model showed a non-significant increase in total cases (+47%, 95% CI: -13%, +149%, p = 0.154); fast breathing cases increased 135% (+39%, +297%, p = 0.001), however, hypoxemia fell 47% (-5%, -70%, p = 0.031) and hospital deaths decreased 36% (-1%, -58%, p = 0.047) in children <5 years. …”

Image3_Sodium–Glucose CoTransporter-2 Inhibitor Empagliflozin Ameliorates Sunitinib-Induced Cardiac Dysfunction via Regulation of AMPK–mTOR Signaling Pathway–Mediated Autophagy.JPE... by Changzhen Ren (10649432)

“…We aimed to determine whether empagliflozin (EMPA), an SGLT2 inhibitor, has a protective role against sunitinib (SNT)-induced cardiac dysfunction in a mouse model.…”

Mid-Gestational Gene Expression Profile in Placenta and Link to Pregnancy Complications by Liis Uusküla (121629)

“…TaqMan RT-qPCR analysis (<em>n</em> = 43; gestational weeks 5–41) confirmed a significant (ANOVA and t-test, FDR <em>P</em><0.05) mid-gestational peak of placental gene expression for <em>BMP5</em>, <em>CCNG2</em>, <em>CDH11</em>, <em>FST</em>, <em>GATM</em>, <em>GPR183</em>, <em>ITGBL1</em>, <em>PLAGL1</em>, <em>SLC16A10</em> and <em>STC1</em>, followed by sharp decrease in mRNA levels at term (t-test, FDR <em>P</em><0.05). …”

Genetic interaction between <i>mec-12(gm379)</i> and <i>unc-104</i>. by Jiun-Min Hsu (660083)

“…Quantifications are mean ± S.E.M. Scale bars  = 5 µm. *, <i>p</i><0.05; **, <i>p</i><0.001; ***, <i>p</i><0.0001, Mann-Whitney U test.…”

Inhibition of SDF-1 signaling alleviates chronic skin inflammation and inhibits leukocyte migration towards SDF. by Silvana Zgraggen (546104)

“…<p>(A) On day -5, hemizygous K14 VEGF-A transgenic mice (n = 14) were sensitized with 2% oxazolone and challenged on day 0 with 1% oxazolone on the ears. …”

Pheromone-responding ORNs and MGC calcium responses in virgin and mated males. by Nina Deisig (178118)

“…Solvent (sol) refers to pooled data of stimulations with hexane and mineral oil. Phe-ORNs show a decreased firing frequency to the pheromone by the addition of heptanal at all doses tested. …”

<i>E2f7/8</i> are essential for polyploidization in the pancreas. by Ramadhan B. Matondo (4763097)

“…<p>(A) Hematoxylin & Eosin staining (400x magnification), top panel and DAPI (630x magnification, 1.5x zoom factor for exocrine, and 630x, 3x zoom factor for endocrine pancreas) lower panel, showing decreased nuclear sizes in <i>78</i>^{<i>∆/∆</i>} compared to control <i>78</i>^<i>f/f</i> mice injected with tamoxifen at day 2 after birth and analysed at the age of 22 weeks. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Characterization of Heterogeneity and Dynamics of Lysis of Single Bacillus subtilis Cells upon Prophage Induction During Spore Germination, Outgrowth, and Vegetative Growth Using R... by Mei-yan Wu (9921201)

“…Major findings of this work are as follows: (i) After addition of xylose to trigger prophage induction, the intensities of Raman spectral bands associated with nucleic acids of single cells in induced cultures gradually fell to zero, in contrast to the much smaller changes in protein band intensities and no changes in nucleic acid bands in uninduced cultures; (ii) the nucleic acid band intensities from an individual induced cell exhibited a rapid decrease, following a long lag period; (iii) after the addition of nutrient-rich medium with xylose, single spores underwent a long period (228 ± 41.4 min) for germination, outgrowth, and vegetative growth, followed by a short period of cell burst in 1.5 ± 0.8 min at a cell length of 8.2 ± 5.5 μm; (iv) the latent time (<i>T</i>_latent) between the addition of xylose and the start of cell burst was heterogeneous in cell populations; however, the period (Δ<i>T</i>_burst) from the latent time to the completion of cell lysis was quite small; (v) in a poor medium with l-alanine alone, addition of xylose caused prophage induction following spore germination but with longer <i>T</i>_latent and Δ<i>T</i>_burst times and without cell elongation; (vi) spontaneous prophage induction and lysis of individual cells from spores in a minimal nutrient medium were observed without xylose addition, and cell length prior to cell lysis was ∼4.1 μm, but spontaneous prophage induction was not observed in a rich medium; (vii) in a rich medium, addition of xylose at a time well after spore germination and outgrowth significantly shortened the average <i>T</i>_latent time. …”

Experimental Analysis of Paraffin Deposition in Slug Flow by Aziz Alhejaili (10331604)

“…As the gas velocity increased, a slight increase in wax deposition was observed due to an increase in heat transfer, leading to a greater radial temperature gradient and, consequently, more wax deposition (∼5 g increase). …”

Transient Protection from Heat-Stress Induced Apoptotic Stimulation by Metastasis-Associated Protein 1 in Pachytene Spermatocytes by Wei Li (7081)

“…</p> <h3>Methodology/Principal Findings</h3><p>High level of MTA1 expression sustained for 1.5 h in primary spermatocytes after heat stress before a notable decrease was detected conversely correlated to the gradual increase of acetylation status of p53 and of p21 level. …”

Image_3_Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain.TIF by Hélène David (8402883)

“…Acute LV dysfunction was associated with global hypoxia, specifically a decrease in sO₂ level in the brain (−5.9%), kidney (−6.4%), and liver (−7.3%) at 4 and 24 h post-MI. …”

Image_1_Combined Algorithm-Based Adaptations of Insulin Dose and Carbohydrate Intake During Exercise in Children With Type 1 Diabetes: Results From the CAR2DIAB Study.tif by Philippe Antoine Lysy (11334060)

“…Objectives<p>To evaluate the evolution of subcutaneous glucose during two sessions of monitored aerobic exercise in children or adolescents with type 1 diabetes after adaptation of insulin doses and carbohydrate intake according to a combined algorithm.</p>Methods<p>Twelve patients with type 1 diabetes (15.1 ± 2 years; diabetes duration: 9.5 ± 3.1 years) performed two series of exercise sessions after cardiac evaluation. …”

Supplementary Material for: Age-Related Association of Calcitonin with Parameters of Anthropometry, Bone and Calcium Metabolism during Childhood by Sonntag J. (9759320)

“…<b><i>Introduction:</i></b> The thyroid parafollicular hormone calcitonin (CT) shows particularly high blood levels in early childhood, a period of high bone turnover, which decrease with increasing age. …”

Increase in Female Liver Cancer in The Gambia, West Africa: Evidence from 19 Years of Population-Based Cancer Registration (1988–2006) by Dominique Sighoko (225218)

“…Male to female ratio showed a significant decrease between the two periods from 3.28∶1 (95% CI, [2.93–3.65]) to 2.2∶1 (95% CI, [1.99–2.43]). …”