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ns decrease » _ decrease (Expand Search), a decrease (Expand Search), use decreased (Expand Search)
we decrease » _ decrease (Expand Search), a decrease (Expand Search), mean decrease (Expand Search)
nm decrease » _ decrease (Expand Search), a decrease (Expand Search), gy decreased (Expand Search)
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Difference in changes in ODI and EQ-5D-5L scores among three groups (n = 45).
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Changes in outcome measures after treatment completion in the three groups.
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Changes in vital signs (Week4 vs. Week0) after treatment completion within the three groups.
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Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement.
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Fluorescent intensity at 520 nm (RNase A/B) and 556 nm (DNase I) versus time for nucleases in DI water lysed with Lyse-It at 30% and 50% power for varying time.
Published 2019“…<b>(A)</b> 20 pM RNase A <b>(B)</b> 46 pM RNase B, <b>(C)</b> 10.5 nM DNase I. As microwave power and time increase, nuclease activity decreases.…”
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2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2)
Published 2023“…To develop more potent compounds, we initiated a structure–activity relationship study that identified 2-aminobenzoxazole as a viable scaffold. …”
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Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben...
Published 2021“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC<sub>50</sub> 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”