Simvastatin administration to mice decreased prenylation of specific small G proteins, as measured by a decrease in their membrane association. by Stephen R. Spindler (183870)

Nanomolar Caffeic Acid Decreases Glucose Uptake and the Effects of High Glucose in Endothelial Cells by Lucia Natarelli (823310)

“…In HG, the presence of 10 nM caffeic acid was associated with a decrease of glucose uptake but not to changes of GLUT-1 membrane localization or mRNA levels. …”

A Y45F mutation in hepatitis C virus NS4A causes a decrease in infectious viral titer. by Allison E. Roder (6312761)

KLF4 knockdown decreased the population of cancer stem cells and cell migration in A431 cells. by Juan Li (146180)

Decreased tumorigenicity of A549 cells <i>in vivo</i> with reduced IQGAP3 expression. by Ying Yang (24175)

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor by Beatrice Noce (16540800)

“…We found that <b>9a</b>, bearing a pargyline moiety, is also able to selectively inhibit MAOB over MAOA (465-fold) with an IC₅₀ of 0.182 μM, being the first-in-class dual NOX2/MAOB covalent inhibitor. …”

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer by Fan-Fan Shang (16953264)

“…Among them, derivative <b>A11</b> had the most potent antiproliferative activity against A549 lung cancer cells (IC₅₀ = 0.009 μM) and was approximately 10-fold more potent than CuB, while the cytotoxicity of <b>A11</b> toward normal L02 cells was about 10-fold less potent, indicating a much wider therapeutic window than CuB. …”

APAP bioactivation is decreased in fructose-fed mice. by Sungjoon Cho (4385851)

Taurolidine lock solution for catheter-related bloodstream infections in pediatric patients: A meta-analysis by Yan Sun (22436)

“…The number of catheters removed due to infection or suspected infection was not significantly different between the two groups (RR: 0.68; 95% CI:0.22, 2.10; I² = 56%; P = 0.50) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0231110#pone.0231110.g005" target="_blank">Fig 5</a>). …”

Nectin-1 staining is decreased in HSV1-infected keratinocytes, but enhanced as a collar in surrounding uninfected cells. by Hafsa Rana (8201886)

Preliminary search for price decreases for the period 01 Jan. 2021–14 Jun. 2022. by Jevgeni Tarassov (13889285)

Decreased by Violet R. Mukaro (282939)

Table 1_Effect of decreased suspended sediment content on chlorophyll-a in Dongting Lake, China.docx by Le Zhang (88249)

The effect of alexidine, amorolfine and olorofim on <i>S</i>. <i>aurantiacum</i> morphology and cell parameters. by Rodrigo Rollin-Pinheiro (239450)

Increasing temperature decreases oxygen concentration and decreasing oxygen content decreases neuronal excitability. by Yuguo Yu (172221)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Pre-match open aortic group. by Tomi Obafemi (12328433)

“…However, the incidence of post-op ventilator associated pneumonia (VAP) decreased from 5.0% to 2.1% (p = 0.003) and post-op urinary tract infections (UTIs) from 8.3% to 3.6% (p<0.001). …”

K8 knockdown leads to a decrease in migration. by Nileema Khapare (159958)

COVID-19 incidence increases over time with a decreased importance of genetic COVID-19 susceptibility. by C. A. Robert Warmerdam (12568808)