Showing 621 - 640 results of 104,467 for search '(( 50 ((ns decrease) OR (we decrease)) ) OR ( 5 ((wt decrease) OR (a decrease)) ))', query time: 1.43s Refine Results
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    GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

    Published 2021
    “…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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    Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

    Published 2021
    “…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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    Severe decreases of TECs and impaired TEC expansion in the absence of mTORC1/Raptor. by Hong-Xia Wang (288934)

    Published 2016
    “…The gating strategy is shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002370#pbio.1002370.s003" target="_blank">S2 Fig</a>. …”
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    Desmosomal Cadherins Are Decreased in Explanted Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patient Hearts by Alexia Vite (462320)

    Published 2013
    “…Genetic studies have demonstrated the central role of desmosomal proteins in this disease, where 50% of patients harbor a mutation in a desmosmal gene. …”
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    Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

    Published 2019
    “…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”
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    Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d’Ivoire: A model-based analysis by Eric N. Ouattara (6890174)

    Published 2019
    “…<i>Immediate ART</i> increased the 5-year HIV care budget from $801.9M to $812.6M compared to <i>ART<350/μL</i>.…”