Heme exposure of HO-1KO A549 cells leads to lysosomal rupture and loss of viability which is prevented by pre-incubation with DFO. by Lilibeth Lanceta (782925)

Flipping the Switch: Reverse-Demand Voltage-Sensitive Fluorophores by Jack T. McCann (13047830)

“…Our group has been developing voltage-sensitive fluorophores (VF dyes) that respond to changes in biological membrane potential (<i>V</i>_m). We hypothesize that the mechanism of voltage sensitivity arises from acceptor PeT (a-PeT) from an electron-rich aniline-containing molecular wire into the excited-state fluorophore, resulting in decreased fluorescence at negative <i>V</i>_m. …”

<i>Donson</i> deletion in the <i>Emx1</i> lineage reduces the size of the early dorsomedial pallium. by Sathish Venkataramanappa (10331993)

Climate variable summary. by Dawn Robin Magness (6157265)

Image_1_Genetic knockout of NTRK2 by CRISPR/Cas9 decreases neurogenesis and favors glial progenitors during differentiation of neural progenitor stem cells.tif by Audrey Roussel-Gervais (14925519)

Data_Sheet_1_Soil Properties Interacting With Microbial Metagenome in Decreasing CH4 Emission From Seasonally Flooded Marshland Following Different Stages of Afforestation.docx by Qian Zhang (49333)

“…Both abundances of mcrA and pmoA genes decreased significantly with increasing plantation age. …”

IL-15 treatment results in decreased lipid deposition in 3T3-L1 mature adipocytes and IL-6 and KC production with increasing IL-15 treatment. by Nicole G. Barra (317230)

<i>Nkx2-1</i>-Cre-mediated deletion of <i>Donson</i> induces apoptosis in the mGE. by Sathish Venkataramanappa (10331993)

The ratio of seed chemical (total mass-standardized peak area of potential defensive compounds) to physical defence (seed coat thickness) of five <i>Macaranga</i> species decreased... by Pimonrat Tiansawat (577916)

Mefunidone decreased collagen I, collagen III, α-smooth muscle actin (α-SMA) and fibronectin (FN) expression in the obstructive kidneys after UUO at 14 days. by Chunyan Liu (44864)

“…<p><b><i>A</i>.</b> Mefunidone affected collagen I (left) and collagen III (right) protein expression in the obstructed kidneys stained by immunohistochemistry (×200). …”

Hsp72 overexpression decreases total NF-κB-p65 in resting cells and reduces steady state IκBα protein levels. by Patrick W. Sheppard (586664)

“…<p>A. Model simulations directly reducing IκBα protein synthesis suggest mechanism inconsistent with data. …”

Effects of <em>APOA5 −1131T>C</em> (rs662799) on Fasting Plasma Lipids and Risk of Metabolic Syndrome: Evidence from a Case-Control Study in China and a Meta-Analysis by Chunxiao Xu (311834)

“…<div><p>The apolipoprotein A5 (<i>APOA5</i>) gene <i>−1131T>C</i> (rs662799) has been suggested to be involved in the pathway of lipid homeostasis and the development of metabolic syndrome (MetS). …”

IGF-I decreases cell doubling time and induces the expression of Survivin at both mRNA and protein levels in the NRP-152 rat prostatic epithelial cell line. by Kyung Song (211116)

Zbtb7a is a widespread promoter- and enhancer-associated factor. by José Miguel Ramos Pittol (5309837)

“…(G) Enrichment of GO annotations among genes whose promoters are associated with Zbtb7a peaks (first column, “Zbtb7a promoter peak”) or with increased or decreased mRNA expression in control fibroblasts, compared to Zbtb7a-knockdown fibroblasts (second and third columns). …”

The <em>ABCA1</em> Gene R230C Variant Is Associated with Decreased Risk of Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease (GEA) Study by Teresa Villarreal-Molina (119637)

“…</p> <h3>Results</h3><p>The C230 allele was significantly associated with both lower HDL-C levels and a lower risk of premature CAD as compared to controls (OR = 0.566; <em>P_add</em> = 1.499×10⁻⁵). …”

Selectivity of PRMT5 inhibition with C220. by Shelby L. Sloan (10803222)

“…For all cell lines, effects of PRMT5 inhibition with C220 treatment on biomarkers of PRMT5 activity shows a dose-dependent decrease in global marks of symmetric di-methylarginine (SDMA) and symmetric di-methylation of histone H4 arginine-3 (H4R3me2s) with a minimal effect to PRMT5 or global asymmetric di-methylarginine (ADMA). …”

Table_1_Previous Use of Anti-Vascular Endothelial Growth Factor Receptor Agents Decreases Efficacy of Fruquintinib in Metastatic Colorectal Cancer Refractory to Standard Therapies.... by Lei Wang (6656)

“…Progression-free survival (PFS) and overall survival (OS) were assessed by a Kaplan-Meier analysis and log-rank test. A Cox regression model was performed to identify independent prognostic factors.…”

Propofol increased the number of the hippocampal pyramidal neurons and decreased the expression of the LC3-II protein and the number of lysosomes and autophagosomes in the ischemic... by Derong Cui (326839)

“…Statistical analyses were performed using a one-way ANOVA. **<i>p</i> < 0.01 vs. control group; ^##<i>p</i> < 0.01 vs. …”

Loss of <i>FGR41</i> attenuates virulence in a host immune system dependent manner. by Andrew S. Wagner (11331477)

Presentation_1_Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Re... by Jo-Fan Chang (6237680)

“…In conclusion, the data suggest that sildenafil and vardenafil induce PDE5-independent apoptotic sensitization to doxorubicin (or other topoisomerase II inhibitors) through impairment of both HR and NHEJ repair systems that are evident by a decrease of nuclear Rad51 levels and their foci formation in the nucleus, and an inhibition of Ku80 DNA end-binding capability. …”