Data_Sheet_1_Finger-specific effects of age on tapping speed and motor fatigability.docx by Caroline Heimhofer (19735888)

“…</p>Results<p>We found that the maximal tapping speed differed significantly between young (18–30 years, n = 194) and aged (50–70 years, n = 176), whereas the fatigability-induced relative decrease in movement speed did not differ between the age groups (average decrease: 17.0% ± 6.9% (young) vs. 16.5% ± 7.5% (aged) decrease). …”

Runx1 attenuates PM proliferation. by Kfir Baruch Umansky (783699)

“…<i>Runx1</i>^<i>L/L</i> and <i>Runx1</i>^<i>f/f</i> proliferating PM cultures were stained with anti-MHC Ab and DAPI and the fractions (in %) of single (blue), double (red) and multinucleated (≥ 3, green) cells are shown. Values are mean±SE (n = 4, *<i>p</i> <0.05). (G to J) Proliferating WT PM were infected with either Ad5CMV-eGFP or Ad-Runx1 and then grown for 24 h in differentiation medium prior to analysis. …”

Internalization segregates active and inactive β₂ARs. by Tien-Hung Lan (229446)

“…<p><b>A</b>, schematic representation of recruitment of wild-type (wt) β₂AR-Rluc8 and wt β₂AR-V to coated pits and internalization (<i>left</i>), and segregation of wt β₂AR-Rluc8 and β₂AR D113S-V (<i>right</i>). …”

Supplementary Material for: Nomograms of Fetal Right Ventricular Fractional Area Change by 2D Echocardiography by Guirado L. (6174176)

Temporal Evaluation of Coronary Revascularization Procedures Performed through the Unified Health System (SUS) in Brazil: a 20-year overview by Igor Ribeiro de Castro Bienert (6125738)

“…Similarly, the number of primary angioplasties increased between 2004 and 2015 (from 1,901 to 8,524). There was a decrease in the mean length of hospital stay (from 14.4 to 12.8 days) and hospital mortality (from 7.6% to 5.9%) for surgical revascularizations, and decrease in mean length of hospital stay (from 5.3 days to 3.7 days) but maintenance of the mortality rates (2.2%) for percutaneous revascularizations. …”

The expression of BDNF is reduced in the cerebral cortex and striatum of ceruloplasmin-deficient mice. by Sarah J. Texel (343929)

“…</b> RT-PCR measures of the 4 BDNF transcripts show a decrease in BDNF transcripts 1, 2 and 4 in the cortex of the CpKO mouse (*p<0.04, n = 5). …”

<i>Hdac3</i> genetic reduction does not reverse transcriptional dysregulation in R6/2. by Lara Moumné (139215)

“…<p>(A) Expression of <i>Bdnf</i> transcripts from different promoters (<i>Bdnf I</i>, <i>IV</i> and <i>V</i>) and the coding region (<i>Bdnf B</i>) in the cortex are represented as a percent of WT expression levels. …”

Image_2_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…</p><p>Aim: To evaluate mRNA expression of P-gp/MRP-1 and HDAC2 in PBMCs of steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS) patients, and determine the relationship between expression of HDAC2 and P-gp/ MRP-1in NS patients.</p><p>Methods: Twenty subjects (10 in each group), SSNS (mean age 7.54 ± 3.5 years), and SRNS (mean age 8.43 ± 3.8 years) were recruited. mRNA expression of HDAC2 and P-gp/MRP-1 was studied by quantitative real time PCR. …”

Image_4_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…</p><p>Aim: To evaluate mRNA expression of P-gp/MRP-1 and HDAC2 in PBMCs of steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS) patients, and determine the relationship between expression of HDAC2 and P-gp/ MRP-1in NS patients.</p><p>Methods: Twenty subjects (10 in each group), SSNS (mean age 7.54 ± 3.5 years), and SRNS (mean age 8.43 ± 3.8 years) were recruited. mRNA expression of HDAC2 and P-gp/MRP-1 was studied by quantitative real time PCR. …”

Image_3_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…</p><p>Aim: To evaluate mRNA expression of P-gp/MRP-1 and HDAC2 in PBMCs of steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS) patients, and determine the relationship between expression of HDAC2 and P-gp/ MRP-1in NS patients.</p><p>Methods: Twenty subjects (10 in each group), SSNS (mean age 7.54 ± 3.5 years), and SRNS (mean age 8.43 ± 3.8 years) were recruited. mRNA expression of HDAC2 and P-gp/MRP-1 was studied by quantitative real time PCR. …”

Image_1_Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome.tif by Harshit Singh (6724346)

“…</p><p>Aim: To evaluate mRNA expression of P-gp/MRP-1 and HDAC2 in PBMCs of steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS) patients, and determine the relationship between expression of HDAC2 and P-gp/ MRP-1in NS patients.</p><p>Methods: Twenty subjects (10 in each group), SSNS (mean age 7.54 ± 3.5 years), and SRNS (mean age 8.43 ± 3.8 years) were recruited. mRNA expression of HDAC2 and P-gp/MRP-1 was studied by quantitative real time PCR. …”

Differing dissociation kinetics of oligonucleotides from TraI36 by Sarah L. Williams (13547)

“…All rights reserved</p> TraI36 was combined with 4 nM 5′-TAMRA-labeled WT 17-base ( and ), WT Hairpin () or G144′C Hairpin () oligonucleotide. …”

Identification of AppY binding sequence <i>in vivo</i> and <i>in vitro</i>. by Naoual Derdouri (14808923)

“…Schematic representation of the pull-down assay. 1) Lysates containing AppY_WT-3Flag, AppY_K170E-3Flag or, as a control, a lysate made from cells containing the empty vector (pQE80L) were incubated with anti-Flag beads for purification. 2) Beads loaded with AppY_WT-3Flag or AppY_K170E-3Flag were incubated with DNA fragments labelled with Cy5 and corresponding to the promoter regions of <i>hyaA</i>, <i>gadE</i>, <i>gadY</i> or <i>malEK</i> as a control. …”

CD11b⁺ CD11c^high cell activation during <i>L</i>. <i>infantum</i> infection is enhanced in TLR4-deficient mice. by Laís Amorim Sacramento (8623041)

“…<p>(A-C) WT and <i>Tlr4</i>^-/- mice were i.v. infected with 10⁷ <i>L</i>. …”

<i>cd9b</i> mutant pairs lay smaller clutches of eggs with significantly fewer fertilised eggs. by Sarah Greaves (11772721)

“…This increase is apparent in (C), where the average breakdown of clutches from WT and <i>cd9b</i> mutant pairs is shown. The additional loss of <i>cd9a</i> in <i>cd9</i> dKOs did not result in a further decrease in the fertilisation rate (D). …”

Table2_Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.DOCX by Dan Ouyang (554436)

“…Pooled results demonstrated as follows: 1) Compared with methotrexate (MTX) alone, IGU alone was superior in improving ACR20 and DAS28-ESR, while having no significant difference in ACR50 and ACR70 [ACR20: (RR 1.15, 95% CI 1.05–1.27, p = 0.004); ACR50: (RR 0.97, 95% CI 0.66–1.44, p = 0.88); ACR70: (RR 0.92, 95% CI 0.45–1.90, p = 0.83); DAS28-ESR: mean difference (MD) −0.15, 95% CI −0.27 to −0.03, p = 0.01]. 2) Compared with MTX alone, IGU + MTX was more effective in improving ACR20, ACR50, ACR70, and DAS28-ESR. …”

DataSheet1_Effectiveness and Safety of Iguratimod Monotherapy or Combined With Methotrexate in Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.ZIP by Dan Ouyang (554436)

“…Pooled results demonstrated as follows: 1) Compared with methotrexate (MTX) alone, IGU alone was superior in improving ACR20 and DAS28-ESR, while having no significant difference in ACR50 and ACR70 [ACR20: (RR 1.15, 95% CI 1.05–1.27, p = 0.004); ACR50: (RR 0.97, 95% CI 0.66–1.44, p = 0.88); ACR70: (RR 0.92, 95% CI 0.45–1.90, p = 0.83); DAS28-ESR: mean difference (MD) −0.15, 95% CI −0.27 to −0.03, p = 0.01]. 2) Compared with MTX alone, IGU + MTX was more effective in improving ACR20, ACR50, ACR70, and DAS28-ESR. …”

HAMLET-antibiotic combination treatment eradicates pneumococci during nasopharyngeal colonization. by Laura R. Marks (311432)

“…Significance was indicated as follows: * = <i>P</i><0.05, ** = <i>P</i><0.01, ns  =  non-significant.</p>…”

Table 1_Integrative multiomics analysis reveals association of gut microbiota and its metabolites with susceptibility to keloids.xls by Dang Li (16400478)

K6 on Ub is required to direct lens denucleation. by Andrea Caceres (239354)

“…In addition, lenses that express K6W-Ub (panel 6) show decreased levels of phosphorylated lamin A/C (green) toward the lens core as compared to Wt (panel 5). …”