Video_3_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.WMV حسب Henryk Majczyński (830716)

"…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …"

Video_6_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.WMV حسب Henryk Majczyński (830716)

"…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …"

Video_1_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.WMV حسب Henryk Majczyński (830716)

"…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …"

Video_2_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.WMV حسب Henryk Majczyński (830716)

"…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …"

Video_4_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.WMV حسب Henryk Majczyński (830716)

"…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …"

Image_1_Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.JPEG حسب Henryk Majczyński (830716)

"…Little is known about the role of 5-HT receptors in the control of voluntary locomotion, so we administered inverse agonists of 5-HT₂ (Cyproheptadine; Cypr), 5-HT_2A neutral antagonist (Volinanserin; Volin), 5-HT_2C neutral antagonist (SB 242084), and 5-HT_2B/2C inverse agonist (SB 206553) receptors intrathecally in intact rats and monitored their effects on unrestrained locomotion. …"

Conditional Trhn OE in adult glia induces EB experience-dependent 5-HT up-regulation and pruning. حسب Vanessa Kay Miller (19775496)

"…(<b>C)</b> Quantification of 5-HT fluorescence intensities in 18°C control (blue) and 28°C <i>Trhn</i> OE (red) conditions. …"

Downregulation of DOM decreases the abundance of PER and TIM. حسب Zhenxing Liu (399809)

"…Downregulation of DOM decreased PER levels at CT1-5 and CT17-21. (Scale bar: 50 um.) …"

FTY720 treatment decreased tumor growth in a xenograft model of hepatoblastoma. حسب Laura L. Stafman (6577184)

"…There was a trend toward decreased Ki67 staining in FTY720-treated tumors (p = 0.29). …"

<b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b> حسب Muhammad Saad Yousuf (20745168)

HoxA9-ER directly represses <i>Cebpa</i> gene expression in myeloid cells. حسب Lei Peng (260321)

Identification of Gut Microbiota Biomarker Genera Distinguishing Wild and Captive Animals (A) Top 50 discriminative genera selected by random forest classifier, ranked by mean decrease accuracy. حسب Lin Xu (94491)

Correlation between hub genes and 50 hallmark signaling pathways. حسب Jiyong Zhang (2498740)

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. حسب Hope Murphy (8843516)

The IC50 value of Tan in normal esophageal HET-1A cells. حسب Dong Yang (141041)

Assessment of exoprotein concentration in a 50-mL culture of MH96. حسب Marion Schoof (11999106)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"

Host population bottlenecks decrease microbiome diversity. حسب Michael Ørsted (5926028)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. حسب Laura L. Stafman (6577184)

"…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …"