Correlation between hub genes and 50 hallmark signaling pathways. by Jiyong Zhang (2498740)

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. by Hope Murphy (8843516)

The IC50 value of Tan in normal esophageal HET-1A cells. by Dong Yang (141041)

Assessment of exoprotein concentration in a 50-mL culture of MH96. by Marion Schoof (11999106)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Mutations in <i>DHFR-TS</i> and their role in methotrexate resistance. by Sophia Bigot (16469992)

Placental gene expression at E9.5 and E11.5. by Hui Zhao (7395)

Delayed boosting with ALVAC-HIV/AIDSVAX B/E or AIDSVAX B/E increases breadth of Env-specific IgG response. by LaTonya D. Williams (3140490)

Inactivation of one allele of FT5. by Sophia Bigot (16469992)

Number of significantly significant (P < 0.05) differentially abundant (SSDA) proteins showing increased or decreased activity (fold change +/- 1.5-fold) relative to time 0 followi... by Peter E. Lillis (12368582)

Knocking down <i>ETH</i> arrests ovarian development and decreases JH signaling under SD condition. by Shuang Guo (294074)

Step-wise evolution of drug resistance via CNV and LOH. by Pétra Vande Zande (17628246)

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

Pulse Ultrasound-Based Response Enhancement of a MOX Gas Sensor by Yumin Yang (5737235)

“…For 2 ppm methanol, the RE by the pulse ultrasound is 50%, relative to the continuous ultrasound, when the pulse width, duty ratio, and working frequency are 0.4 ms, 50%, and 110.1 kHz, respectively. …”

Pulse Ultrasound-Based Response Enhancement of a MOX Gas Sensor by Yumin Yang (5737235)

“…For 2 ppm methanol, the RE by the pulse ultrasound is 50%, relative to the continuous ultrasound, when the pulse width, duty ratio, and working frequency are 0.4 ms, 50%, and 110.1 kHz, respectively. …”

Dox-inducible expression of HA-MAD1 in colon is sufficient to decrease p53 expression and cause chromosome missegregation. by Sarah E. Copeland (13951506)

Estimates of the phenotypic mean, environmental variance (<i>V</i>_<i>E</i>), additive genetic variance (<i>V</i>_<i>A</i>), and heritability (<i>h</i><sup><i>2... by Ryan M. Imrie (15810854)

E₅₀ values. by Junxia Zhou (14381598)

The I827K substitution destabilizes the 3D fold of E6AP^C-lobe (residues 761–875). by Steven A. Beasley (9099461)