Toll-Like Receptor 9 Deficiency Protects Mice against <i>Pseudomonas aeruginosa</i> Lung Infection by Fatima BenMohamed (530333)

“…While a number of studies have demonstrated the roles of TLR2, TLR4 and TLR5 in host defense againt <i>P. aeruginosa</i> infection, the implication of TLR9 in this process has been overlooked. …”

Internet-Delivered Cognitive Behavior Therapy for Adolescents with Obsessive-Compulsive Disorder: An Open Trial by Fabian Lenhard (581252)

“…However, a substantial proportion of patients do not have access to such treatment. We developed and tested the feasibility, efficacy and acceptability of a novel therapist-guided, Internet-delivered CBT (ICBT) platform for adolescents with OCD.…”

Table_4_Deciphering the influence of dietary synbiotics in white shrimp gut and its effects in regulating immune signaling pathways.doc by Sofia Priyadarsani Das (17830028)

“…However, the effects of synbiotics on the white shrimp intestinal microbiota remain poorly understood. In the present study, we targeted the V3–V4 region of 16S rRNA genes to analyze the effects of synbiotics on white shrimp gut microbiota. …”

Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immu... by Keita Fukao (524548)

“…<div><p>Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA synthesis of influenza viruses. In the present study, we evaluated the efficacy of BXM against influenza virus infection in mouse models. …”

Supplementary Material for: Trends in Adherence to Recommended Physical Activity and Its Association with Mortality and Disease Progression among US Adults with Chronic Kidney Dise... by Qu X. (14068626)

“…<b><i>Results:</i></b> For the CKD population, adherence rate increased from 48.2% in 2007–08 to 55.0% in 2017–18, and sedentary time peaked in 2013–14 (7.5 h/day) and then decreased afterward. There was no difference in the trends across the non-CKD and CKD population. …”

Table 2_Pan-cancer analysis of phagocytosis regulators in female-specific cancers: a focus on HMGB2.xlsx by Xiaoqin Lu (3121482)

“…High-frequency mutations were found in PTEN, ARID1A, and UBR4. Genes like COX5B and MS4A1 emerged as potential predictors of clinical outcomes and therapeutic response. …”

Image_1_Case Report: Pathological Complete Response in a Lung Metastasis of Phyllodes Tumor Patient Following Treatment Containing Peptide Neoantigen Nano-Vaccine.pdf by Huizi Sha (12057872)

“…Peripheral blood immune monitoring demonstrated immune reactivity against a series of peptides, with the most robust post-vaccine T-cell response detected against the HLA-DRB1*0901-restricted SLC44A5 V54F peptide.</p>…”

Epigenetic Changes during Hepatic Stellate Cell Activation by Silke Götze (111288)

“…To identify genes which may be regulated by DNA methylation, we performed a genome-wide Methyl-MiniSeq EpiQuest sequencing comparing quiescent and early culture-activated HSC. …”

Presentation_1.PDF by Mario Martínez-Florensa (509543)

“…Accordingly, CD6.PD3 triggers a decrease in serum levels of both pro-inflammatory cytokines and bacterial load. …”

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer by Nafees Muhammad (5641151)

“…As a result, <b>PFL</b> disrupts the mitochondrial ultrastructure and induces significant alterations in the mitochondrial membrane potential, which further leads to an increase in production of reactive oxygen species (ROS) and a decrease in ATP synthesis in MDA-MB-231 TNBCs. Western blot analysis reveals the formation of ternary complex of thymidylate synthase, which shows the intracellular conversion of tegafur into 5-FU after its release from <b>PFL</b>. …”

Image_4_Integrated Isoform Sequencing and Dynamic Transcriptome Analysis Reveals Diverse Transcripts Responsible for Low Temperature Stress at Anther Meiosis Stage in Rice.TIF by Zhaojun Qu (9012878)

“…<p>Low temperatures stress is one of the important factors limiting rice yield, especially during rice anther development, and can cause pollen sterility and decrease grain yield. In our study, low-temperature stress decreased pollen viability and spikelet fertility by affecting the sugar, nitrogen and amino acid contents of anthers. …”

Mineral composition, histomorphometry, and bone biomechanical properties are improved with probiotic, prebiotic, and symbiotic supplementation in rats chronically exposed to passiv... by Marcelo Fernandes Tribst (6677657)

“…<div><p>ABSTRACT: Cigarette smoke in large centers is one of the most important causes of chronic inflammatory diseases in public health and is associated with a decrease in bone mass, consolidation process, and bone remodeling. …”

Image_1_The sensitivity of photosynthesis to magnesium deficiency differs between rice (Oryza sativa L.) and cucumber (Cucumis sativus L.).tif by Xusheng Meng (14610803)

“…A lower CO₂ concentration in chloroplasts (C_c) was accompanied by a decrease in the maximum rate of electron transport (J_max) and the maximum rate of ribulose 1,5-bisphosphate carboxylation (V_cmax), restricting CO₂ utilization in Mg-deficient plants. …”

Image_1_Characteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling.tif by Dehong Wu (2236318)

“…Furthermore, we identified the elevation of two sterols (Lan and Chol), and the reduction of one corticoid (11-DeoxyF) and two progestins (5α-DHP and 11β-OH-Prog) in patients.…”

Revealing Dynamics of Accumulation of Systemically Injected Liposomes in the Skin by Intravital Microscopy by James I. Griffin (4521922)

“…Accumulation of intravenously injected cytotoxic liposomes in the skin induces serious toxicity. We used single time point and longitudinal intravital microscopy to understand skin accumulation dynamics of non-PEGylated and PEGylated liposomes after systemic injection into mice. …”

Effect of errors in the cooperation index η provided by different social norms. by Fernando P. Santos (848210)

“…<p>a) <b>Assignment error (</b><i>α</i><b>):</b> We allow for mistakes to happen when a bystander attributes a new public reputation. …”

Identification and Functional Validation of Caldesmon as a Potential Gastric Cancer Metastasis-associated Protein by Qian Hou (672015)

“…In this study, we aim to identify biomarkers for gastric cancer metastasis using a quantitative proteomics approach. …”

Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes by V.X. Farias (6800060)

“…On the other hand, the protein level of SMIT1 decreased by 42.5, 41.3, and 44.8% in the SN after 4, 8, and 12 weeks of diabetes, respectively. …”

Revealing Dynamics of Accumulation of Systemically Injected Liposomes in the Skin by Intravital Microscopy by James I. Griffin (4521922)

“…Accumulation of intravenously injected cytotoxic liposomes in the skin induces serious toxicity. We used single time point and longitudinal intravital microscopy to understand skin accumulation dynamics of non-PEGylated and PEGylated liposomes after systemic injection into mice. …”

Data_Sheet_1_In vitro antimicrobial activity and resistance mechanisms of the new generation tetracycline agents, eravacycline, omadacycline, and tigecycline against clinical Staph... by Weiliang Zeng (4252582)

“…<p>In this study, we investigated the in vitro activity and resistance mechanisms of the new generation tetracycline agents, namely eravacycline, omadacycline, and tigecycline, against Staphylococcus aureus isolates. …”