Data_Sheet_1_Use of Carboxyhemoglobin as an Early Sign of Oxygenator Dysfunction in Patients Supported by Extracorporeal Membrane Oxygenation.PDF by Vladimir L. Cousin (12478992)

“…HbCO values at oxygenator change [HbCO median 2.7 (IQR 2.5–3.5)] were significantly higher than the HbCO values 1 week before [HbCO median 2.07 (IQR 1.86–2.8)] (p value < 0.001).…”

Data_Sheet_1_Characterizing the Intra-Vineyard Variation of Soil Bacterial and Fungal Communities.docx by Hebin Liang (6758411)

“…Simultaneously assessing shifts of microbial community composition at the intra-vineyard scale allows us to decouple correlations among environmental variables, thus providing insights into vineyard management. Here we investigated bacterial and fungal community compositions and their relationships with edaphic properties in soils collected from a commercial vineyard at four different soil depths (0–5, 5–10, 10–20, and 20–40 cm). …”

Multicomponent System of NPS-1034, an Orally Administered Lung Cancer Drug Candidate, with Sulfonic Acids and Solid State Characterization by Jangmi Lee (1875595)

“…However, NPS-1034 is practically insoluble in almost all organic solvents as well as aqueous media (pH 1, 4.5, and 7.5). We attempted to improve the physicochemical properties of NPS-1034 by forming multicomponent systems with a wide variety of sulfonic acids including methanesulfonic acid, 1,2-ethanedisulfonic acid, <i>p</i>-toluenesulfonic acid, and camphorsulfonic acid. …”

Data_Sheet_1_Different Associations Between the IREB2 Variants and Chronic Obstructive Pulmonary Disease Susceptibility.docx by Qiaoli Zeng (9452591)

“…</p><p>Results: This meta-analysis included a total of 4,096 patients and 5,870 controls. Here, we investigated the 5 IREB2 variants to identify COPD risk. …”

Image1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

Knockdown of IGFBP7 restored the TGF-β1-induced EMT in HRPTECs. by Jun Watanabe (403029)

“…HRPTECs were transfected with control or IGFBP7 siRNAs (25 nM final concentrations) and subsequently stimulated with TGF-β1 (2.5 ng/ml, 48 h). Lowering the expressions of IGFBP7 proteins reduced the TGF-β1-induced α-SMA expression, but failed to restore the TGF-β1-decreased E-cadherin expression. …”

Table1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.docx by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Data Sheet 1_Gut microbiome dysbiosis in chronic lung disease: a systematic review and meta-analysis.docx by Juan Pan (383653)

“…In COPD, Bacteroides was increased (SMD = 0.76; 95% CI, 0.00 to 1.52; I² = 91%; n=4), while Bifidobacterium (SMD = −0.88; 95% CI, −1.39 to −0.37; I² = 88%; n=5) and Lactobacillus (SMD = -0.73; 95% CI, -1.00 to -0.46; I² = 66%; n=5) were decreased. …”

Supplementary Material for: Mask versus Prongs for Nasal Continuous Positive Airway Pressure in Preterm Infants: A Systematic Review and Meta-Analysis by King B.C. (6795440)

“…Among preterm infants requiring NCPAP, the use of a nasal mask, compared to nasal prongs, decreased the rate of NCPAP failure within 72 h (RR 0.72, 95% CI 0.53–0.97; number needed to treat for an additional beneficial outcome [NNTB] 12.5, 95% CI 7.1–100; 5 trials, 576 participants; low-certainty evidence) and the incidence of nasal injury (RR 0.71, 95% CI 0.59–0.85; NNTB 8.3, 95% CI 5.6–16.7; 6 trials, 665 participants; low-certainty evidence). …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

Data_Sheet_2_Different Associations Between the IREB2 Variants and Chronic Obstructive Pulmonary Disease Susceptibility.XLSX by Qiaoli Zeng (9452591)

“…</p><p>Results: This meta-analysis included a total of 4,096 patients and 5,870 controls. Here, we investigated the 5 IREB2 variants to identify COPD risk. …”

Image2_D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats.pdf by Risako Kato (9633191)

“…After ketamine, d-amphetamine did not significantly accelerate time to emergence compared to saline (saline:19.7 ± 18.0 min; d-amphetamine:20.3 ± 16.5 min, p = 1.00). Prefrontal cortex local field potential recordings revealed that d-amphetamine broadly decreased spectral power at frequencies <25 Hz and restored an awake-like pattern after dexmedetomidine. …”

Data_Sheet_2_Maize and peanut intercropping improves the nitrogen accumulation and yield per plant of maize by promoting the secretion of flavonoids and abundance of Bradyrhizobium... by Qiqi Dong (10860057)

“…The stems and leaves of intercropped peanut significantly decreased by 5.13 and 22.23% (2020) and 14.45 and 24.54% (2021), respectively. …”

DataSheet_1_The nonlinear relationship between thyroid function parameters and metabolic dysfunction-associated fatty liver disease.pdf by Yingying Hu (339770)

“…</p>Results<p>In the RCS models, the risk of MAFLD increased with higher levels of FT3 when FT3 <5.58pmol/L, while the risk of MAFLD decreased with higher levels of FT3 when FT3 ≥5.58pmol/L (P nonlinearity <0.05). …”

Image3_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

Data_Sheet_1_Maize and peanut intercropping improves the nitrogen accumulation and yield per plant of maize by promoting the secretion of flavonoids and abundance of Bradyrhizobium... by Qiqi Dong (10860057)

“…The stems and leaves of intercropped peanut significantly decreased by 5.13 and 22.23% (2020) and 14.45 and 24.54% (2021), respectively. …”

Impact of the Spanish Smoke-Free Legislation on Adult, Non-Smoker Exposure to Secondhand Smoke: Cross-Sectional Surveys before (2004) and after (2012) Legislation by Xisca Sureda (360032)

“…Self-reported exposure decreased from 32.5% to 27.6% (−15.1%, p<0.05) in the home, from 42.9% to 37.5% (−12.6%, p = 0.11) at work/education venues, from 61.3% to 38.9% (−36.5%, p<0.001) during leisure time, and from 12.3% to 3.7% (−69.9%, p<0.001) in public transportation vehicles. …”

Supplementary Material for: Effect of Progesterone Withdrawal on Hypothalamic Mechanisms Related to Prolactin Release in Late Pregnant Rats by Bonafede M.M. (4127374)

“…<i>Methods:</i> To investigate the hypothalamic mechanism mediating this response, we determined expression of tyrosine hydroxylase (TH), PRL receptors (long form, PRLR_<i>long</i>), estrogen-α (ERα) and ERβ, P₄ (PR) A and B receptors, and STAT5a, STAT5b, suppressors of cytokine signaling 1 (SOCS1), SOCS3 and CIS at mRNA (by semiquantitative and real-time RT-PCR) and protein (by Western blot only for TH, ERα and PRs) levels, and dopamine and DOPAC (by high-performance liquid chromatography) contents in the mediobasal hypothalamus (MBH) 24 h after luteolysis induced by a PGF2α analogue (cloprostenol, 25 µg/rat s.c. at 8 and 12 h on day 19 of pregnancy). …”